Effect of carvedilol versus metoprolol CR/XL on mortality in patients with heart failure treated with cardiac resynchronization therapy: A COX multivariate regression analysis

Xuedong Shen, Chandra K. Nair, Wilbert S. Aronow, Tom Hee, Dennis J. Esterbrooks

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We investigated in 136 consecutive patients with heart failure receiving cardiac resynchronization therapy (CRT) the effect of carvedilol versus metoprolol CR/XL versus no beta blocker on mortality. Of the 136 patients, 42 (31%) were on carvedilol, 80 (59%) were on metoprolol CR/XL, and 14 (10%) were not on a beta blocker. A decrease of left ventricular end-systolic volume ≥15% after CRT was defined as a positive response to CRT. Of the 136 patients, 62 (46%) responded to CRT. It was found that both carvedilol and metoprolol CR/XL were not related to CRT response on using Cox univariate regression analysis. Twenty-two of the 136 patients (16%) died during follow-up of 17 6 10 months after initiating CRT. Mortality occurred in 14 of 80 patients (18%) on metoprolol CR/XL, in 3 of 42 patients (7%) on carvedilol, and in 5 of 14 patients (36%) not on beta blockers (P = 0.04). After adjustment for age, gender, and the variables with significant differences by Cox univariate regression, both carvedilol (hazard ratio = 0.14; P = 0.03; 95% confidence interval = 0.02-0.86) and metoprolol CR/XL (hazard ratio = 0.19; P = 0.02; 95% confidence interval = 0.04-0.80) were found to be related to mortality by Cox multivariate regression.

Original languageEnglish
Pages (from-to)247-253
Number of pages7
JournalAmerican Journal of Therapeutics
Volume20
Issue number3
DOIs
StatePublished - May 2013

Fingerprint

Cardiac Resynchronization Therapy
Metoprolol
Multivariate Analysis
Heart Failure
Regression Analysis
Mortality
Confidence Intervals
carvedilol
Stroke Volume

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Effect of carvedilol versus metoprolol CR/XL on mortality in patients with heart failure treated with cardiac resynchronization therapy : A COX multivariate regression analysis. / Shen, Xuedong; Nair, Chandra K.; Aronow, Wilbert S.; Hee, Tom; Esterbrooks, Dennis J.

In: American Journal of Therapeutics, Vol. 20, No. 3, 05.2013, p. 247-253.

Research output: Contribution to journalArticle

@article{0ae3e58531b7450f920c8181779e513f,
title = "Effect of carvedilol versus metoprolol CR/XL on mortality in patients with heart failure treated with cardiac resynchronization therapy: A COX multivariate regression analysis",
abstract = "We investigated in 136 consecutive patients with heart failure receiving cardiac resynchronization therapy (CRT) the effect of carvedilol versus metoprolol CR/XL versus no beta blocker on mortality. Of the 136 patients, 42 (31{\%}) were on carvedilol, 80 (59{\%}) were on metoprolol CR/XL, and 14 (10{\%}) were not on a beta blocker. A decrease of left ventricular end-systolic volume ≥15{\%} after CRT was defined as a positive response to CRT. Of the 136 patients, 62 (46{\%}) responded to CRT. It was found that both carvedilol and metoprolol CR/XL were not related to CRT response on using Cox univariate regression analysis. Twenty-two of the 136 patients (16{\%}) died during follow-up of 17 6 10 months after initiating CRT. Mortality occurred in 14 of 80 patients (18{\%}) on metoprolol CR/XL, in 3 of 42 patients (7{\%}) on carvedilol, and in 5 of 14 patients (36{\%}) not on beta blockers (P = 0.04). After adjustment for age, gender, and the variables with significant differences by Cox univariate regression, both carvedilol (hazard ratio = 0.14; P = 0.03; 95{\%} confidence interval = 0.02-0.86) and metoprolol CR/XL (hazard ratio = 0.19; P = 0.02; 95{\%} confidence interval = 0.04-0.80) were found to be related to mortality by Cox multivariate regression.",
author = "Xuedong Shen and Nair, {Chandra K.} and Aronow, {Wilbert S.} and Tom Hee and Esterbrooks, {Dennis J.}",
year = "2013",
month = "5",
doi = "10.1097/MJT.0b013e3181f2abb3",
language = "English",
volume = "20",
pages = "247--253",
journal = "American Journal of Therapeutics",
issn = "1075-2765",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Effect of carvedilol versus metoprolol CR/XL on mortality in patients with heart failure treated with cardiac resynchronization therapy

T2 - A COX multivariate regression analysis

AU - Shen, Xuedong

AU - Nair, Chandra K.

AU - Aronow, Wilbert S.

AU - Hee, Tom

AU - Esterbrooks, Dennis J.

PY - 2013/5

Y1 - 2013/5

N2 - We investigated in 136 consecutive patients with heart failure receiving cardiac resynchronization therapy (CRT) the effect of carvedilol versus metoprolol CR/XL versus no beta blocker on mortality. Of the 136 patients, 42 (31%) were on carvedilol, 80 (59%) were on metoprolol CR/XL, and 14 (10%) were not on a beta blocker. A decrease of left ventricular end-systolic volume ≥15% after CRT was defined as a positive response to CRT. Of the 136 patients, 62 (46%) responded to CRT. It was found that both carvedilol and metoprolol CR/XL were not related to CRT response on using Cox univariate regression analysis. Twenty-two of the 136 patients (16%) died during follow-up of 17 6 10 months after initiating CRT. Mortality occurred in 14 of 80 patients (18%) on metoprolol CR/XL, in 3 of 42 patients (7%) on carvedilol, and in 5 of 14 patients (36%) not on beta blockers (P = 0.04). After adjustment for age, gender, and the variables with significant differences by Cox univariate regression, both carvedilol (hazard ratio = 0.14; P = 0.03; 95% confidence interval = 0.02-0.86) and metoprolol CR/XL (hazard ratio = 0.19; P = 0.02; 95% confidence interval = 0.04-0.80) were found to be related to mortality by Cox multivariate regression.

AB - We investigated in 136 consecutive patients with heart failure receiving cardiac resynchronization therapy (CRT) the effect of carvedilol versus metoprolol CR/XL versus no beta blocker on mortality. Of the 136 patients, 42 (31%) were on carvedilol, 80 (59%) were on metoprolol CR/XL, and 14 (10%) were not on a beta blocker. A decrease of left ventricular end-systolic volume ≥15% after CRT was defined as a positive response to CRT. Of the 136 patients, 62 (46%) responded to CRT. It was found that both carvedilol and metoprolol CR/XL were not related to CRT response on using Cox univariate regression analysis. Twenty-two of the 136 patients (16%) died during follow-up of 17 6 10 months after initiating CRT. Mortality occurred in 14 of 80 patients (18%) on metoprolol CR/XL, in 3 of 42 patients (7%) on carvedilol, and in 5 of 14 patients (36%) not on beta blockers (P = 0.04). After adjustment for age, gender, and the variables with significant differences by Cox univariate regression, both carvedilol (hazard ratio = 0.14; P = 0.03; 95% confidence interval = 0.02-0.86) and metoprolol CR/XL (hazard ratio = 0.19; P = 0.02; 95% confidence interval = 0.04-0.80) were found to be related to mortality by Cox multivariate regression.

UR - http://www.scopus.com/inward/record.url?scp=84880067813&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880067813&partnerID=8YFLogxK

U2 - 10.1097/MJT.0b013e3181f2abb3

DO - 10.1097/MJT.0b013e3181f2abb3

M3 - Article

C2 - 21642836

AN - SCOPUS:84880067813

VL - 20

SP - 247

EP - 253

JO - American Journal of Therapeutics

JF - American Journal of Therapeutics

SN - 1075-2765

IS - 3

ER -