Effect of cetirizine on human eosinophil superoxide generation, eosinophil chemotaxis and eosinophil peroxidase in vitro

Chiharu Okada, Ryosuke Eda, Hidefumi Miyagawa, Haruhito Sugiyama, Russell J. Hopp, Againdra K. Bewtra, Robert G. Townley

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Cetirizine, a potent Hrantagonist, has been reported to inhibit eosinophil migration into human skin. We, therefore, further evaluated the effect of cetirizine on eosinophil function, including superoxide anion generation, chemotaxis, and eosinophil peroxidase (EP) release. In allergic subjects, superoxide anion generation 60 min after platelet-activating factor (PAF) activation was inhibited by concentrations of cetirizine ranging from 0.01 to 1 μg/ml (2.612 ×10-8 to 2.612 × 10-6 M). No significant inhibition was observed in normal subjects. PAF (10-6 M)-induced eosinophil chemotaxis was also inhibited by cetirizine. In allergic subjects, percent inhibitions were 47.5±6.1% at 0.01 μg/ml, 50.8±5.1% at 0.1 μg/ml and 58.9±6.4% at 1 (μg/ml of cetirizine. In allergic subjects, N-formyl-methionyl-lencyl-phenylalanine induced eosinophil chemotaxis was inhibited by cetirizine, although EP release was not. These results suggest cetirizine has effects on eosinophils which can not be explained by H1.

Original languageEnglish (US)
Pages (from-to)384-390
Number of pages7
JournalInternational Archives of Allergy and Immunology
Volume103
Issue number4
DOIs
StatePublished - Jan 1 1994

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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