Effect of chemical and pharmacological agents on the secretory activity induced by Escherichia coli heat-stable enterotoxin

Floyd C. Knoop, D. M. Abbey

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effect of aspirin (ASP), chlorpromazine (CPZ), diphenoxylate (DP), ethylene glycol tetraacetate (EGTA), hydrocortisone (HC), loperamide (LPA), methylprednisolone (MP), phentolamine mesylate (PTM), propranolol (PR), and trifluoperazine (TPZ) on the secretory activity induced by Escherichia coli heat-stable (ST) enterotoxin in infant mice was studied. LPA and DP, which are used therapeutically for diarrhea, did not inhibit the effect of ST enterotoxin; MP and HC, known inhibitors of cholera enterotoxin, and two adrenergic agents (PR and PTM) had no effect on ST-induced secretory activity. TPZ, EGTA, ASP, and CPZ caused a significant (P<0.05) decrease in the secretory activity induced by ST enterotoxin. CPZ, EGTA, and TPZ inhibited secretory activity induced by 8-bromoguanosine 3',5'-cyclic monophosphoric acid (8-BrcGMP), a cGMP analog.

Original languageEnglish (US)
Pages (from-to)754-758
Number of pages5
JournalCanadian Journal of Microbiology
Volume27
Issue number8
StatePublished - Dec 1 1981

Fingerprint

Trifluoperazine
Ethylene Glycol
Enterotoxins
Diphenoxylate
Chlorpromazine
Loperamide
Escherichia coli
Hot Temperature
Phentolamine
Methylprednisolone
Pharmacology
Propranolol
Aspirin
Hydrocortisone
Adrenergic Agents
Diarrhea
Acids

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Immunology
  • Microbiology

Cite this

Effect of chemical and pharmacological agents on the secretory activity induced by Escherichia coli heat-stable enterotoxin. / Knoop, Floyd C.; Abbey, D. M.

In: Canadian Journal of Microbiology, Vol. 27, No. 8, 01.12.1981, p. 754-758.

Research output: Contribution to journalArticle

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