Effect of chemical and pharmacological agents on the secretory activity induced by Escherichia coli heat-stable enterotoxin

F. C. Knoop, D. M. Abbey

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The effect of aspirin (ASP), chlorpromazine (CPZ), diphenoxylate (DP), ethylene glycol tetraacetate (EGTA), hydrocortisone (HC), loperamide (LPA), methylprednisolone (MP), phentolamine mesylate (PTM), propranolol (PR), and trifluoperazine (TPZ) on the secretory activity induced by Escherichia coli heat-stable (ST) enterotoxin in infant mice was studied. LPA and DP, which are used therapeutically for diarrhea, did not inhibit the effect of ST enterotoxin; MP and HC, known inhibitors of cholera enterotoxin, and two adrenergic agents (PR and PTM) had no effect on ST-induced secretory activity. TPZ, EGTA, ASP, and CPZ caused a significant (P<0.05) decrease in the secretory activity induced by ST enterotoxin. CPZ, EGTA, and TPZ inhibited secretory activity induced by 8-bromoguanosine 3',5'-cyclic monophosphoric acid (8-BrcGMP), a cGMP analog.

Original languageEnglish (US)
Pages (from-to)754-758
Number of pages5
JournalCanadian Journal of Microbiology
Volume27
Issue number8
DOIs
StatePublished - Jan 1 1981

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Genetics

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