Effect of cholera enterotoxin on calcium uptake and cyclic AMP accumulation in rat basophilic leukemia cells

Floyd C. Knoop; D. Denee Thomas

doi:10.1016/0020-711X(84)90100-9

Effect of cholera enterotoxin on calcium uptake and cyclic AMP accumulation in rat basophilic leukemia cells

Floyd C. Knoop, D. Denee Thomas

Department of Medical Microbiology and Immunology

Research output: Contribution to journal › Article

4 Scopus citations

Abstract

1. 1. Cholera enterotoxin (CT), at an optimal concentration of 2.38 × 10¹⁰ M, stimulated calcium uptake (P <0.01) and cyclic AMP accumulation (P <0.02) in cultured rat basophilic leukemia cells. 2. 2. No significant effect of CT on calcium release or cyclic GMP accumulation was detected. 3. 3. Pharmacologie and chemical agents which block calcium uptake or prostaglandin synthesis antagonized the effect of CT.

Original language	English (US)
Pages (from-to)	275-280
Number of pages	6
Journal	International Journal of Biochemistry
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/0020-711X(84)90100-9
State	Published - 1984

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All Science Journal Classification (ASJC) codes

Biochemistry

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Knoop, F. C., & Denee Thomas, D. (1984). Effect of cholera enterotoxin on calcium uptake and cyclic AMP accumulation in rat basophilic leukemia cells. International Journal of Biochemistry, 16(3), 275-280. https://doi.org/10.1016/0020-711X(84)90100-9

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abstract = "1. 1. Cholera enterotoxin (CT), at an optimal concentration of 2.38 × 1010 M, stimulated calcium uptake (P <0.01) and cyclic AMP accumulation (P <0.02) in cultured rat basophilic leukemia cells. 2. 2. No significant effect of CT on calcium release or cyclic GMP accumulation was detected. 3. 3. Pharmacologie and chemical agents which block calcium uptake or prostaglandin synthesis antagonized the effect of CT.",

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AB - 1. 1. Cholera enterotoxin (CT), at an optimal concentration of 2.38 × 1010 M, stimulated calcium uptake (P <0.01) and cyclic AMP accumulation (P <0.02) in cultured rat basophilic leukemia cells. 2. 2. No significant effect of CT on calcium release or cyclic GMP accumulation was detected. 3. 3. Pharmacologie and chemical agents which block calcium uptake or prostaglandin synthesis antagonized the effect of CT.

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10.1016/0020-711X(84)90100-9