Effect of cholera enterotoxin on calcium uptake and cyclic AMP accumulation in rat basophilic leukemia cells

Floyd C. Knoop, D. Denee Thomas

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Abstract

1. 1. Cholera enterotoxin (CT), at an optimal concentration of 2.38 × 1010 M, stimulated calcium uptake (P <0.01) and cyclic AMP accumulation (P <0.02) in cultured rat basophilic leukemia cells. 2. 2. No significant effect of CT on calcium release or cyclic GMP accumulation was detected. 3. 3. Pharmacologie and chemical agents which block calcium uptake or prostaglandin synthesis antagonized the effect of CT.

Original languageEnglish (US)
Pages (from-to)275-280
Number of pages6
JournalInternational Journal of Biochemistry
Volume16
Issue number3
DOIs
StatePublished - 1984

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All Science Journal Classification (ASJC) codes

  • Biochemistry

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