Effect of creatine loading on neuromuscular fatigue threshold

Jeffrey Stout, Joan Eckerson, Kyle Ebersole, Geri Moore, Sharon Perry, Terry Housh, Anthony Bull, Joel Cramer, Ash Batheja

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


The purpose of this investigation was to determine the effect of creatine (Cr) loading on the onset of neuromuscular fatigue by monitoring electromyographic fatigue curves from the vastus lateralis muscle using the physical working capacity at the fatigue threshold (PWC(FT)) test. Using a double-blind random design, 15 women athletes [mean age 19.0 ± 2.0 (SD) yr] from the university crew team received a placebo (n = 8; 20 g glucose) or Cr (n = 7; 5 g Cr monohydrate + 20 g glucose) four times per day for 5 consecutive days. Analysis of covariance was used to analyze the data (covaried for presupplementation PWC(FT) values). The adjusted mean postsupplementation PWC(FT) value for the Cr group (mean = 186 W) was significantly (P <0.05) higher than that of the placebo group (mean = 155 W). These findings suggest that Cr loading may delay the onset of neuromuscular fatigue.

Original languageEnglish (US)
Pages (from-to)109-112
Number of pages4
JournalJournal of Applied Physiology
Issue number1
StatePublished - Jan 2000

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)


Dive into the research topics of 'Effect of creatine loading on neuromuscular fatigue threshold'. Together they form a unique fingerprint.

Cite this