Abstract
This study examined the effects of 3 days of estrogen supplementation (ES) on thermoregulation during exercise in premenopausal (20-39 yr) adult women during the follicular phase of the menstrual cycle. Subjects (11 control, 10 experimental) performed upright cycle ergometer exercise at 60% of maximal O2 consumption in a neutral environment (25°C, 30% relative humidity) for 20 min. Subjects were given placebo (P) or β-estradiol (2 mg/tablet, 3 tablets/day for 3 days). All experiments were conducted between 6:30 and 9:00 AM after ingestion of the last tablet. Heart rate, forearm blood flow (FBF), mean skin temperature, esophageal temperature (T(es)), and forearm sweat rate were measured. Blood analysis for estrogen and progesterone reflected the follicular phase of the menstrual cycle. Maximal O2 consumption (37.1 ± 6.2 in P vs. 38.4 ± 6.3 ml · kg-1 · min-1 in ES) and body weight-to-surface area ratio (35.58 ± 2.85 in P vs. 37.3 ± 2.7 in ES) were similar between groups. Synthesis of 70-kDa heat shock protein was not induced by 3 days of ES. Neither the threshold for sweating (36.97 ± 0.15 in P vs. 36.90 ± 0.22°C in ES), the threshold for an increase in FBF (37.09 ± 0.22 in P vs. 37.17 ± 0.26°C in ES), the slope of sweat rate- T(es) relationship (0.42 ± 0.16 in P vs. 0.41 ± 0.17 in ES), nor the FBF- T(es) relationship (10.04 ± 4.4 in P vs. 9.61 ± 3.46 in ES) was affected (P > 0.05) by 3 days of ES. We conclude that 3 days of ES by young adult women in the follicular phase of their menstrual cycle have no effect on heat transfer to the skin, heat dissipation by evaporative cooling, or leukocyte synthesis of 70-kDa heat shock protein.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2082-2088 |
| Number of pages | 7 |
| Journal | Journal of Applied Physiology |
| Volume | 85 |
| Issue number | 6 |
| State | Published - Dec 1 1998 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Physiology
- Physiology (medical)
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Effect of estrogen supplementation on exercise thermoregulation in premenopausal women. / Chang, R. T.; Lambert, G. Patrick; Moseley, P. L.; Chapler, F. K.; Gisolfi, C. V.
In: Journal of Applied Physiology, Vol. 85, No. 6, 01.12.1998, p. 2082-2088.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of estrogen supplementation on exercise thermoregulation in premenopausal women
AU - Chang, R. T.
AU - Lambert, G. Patrick
AU - Moseley, P. L.
AU - Chapler, F. K.
AU - Gisolfi, C. V.
PY - 1998/12/1
Y1 - 1998/12/1
N2 - This study examined the effects of 3 days of estrogen supplementation (ES) on thermoregulation during exercise in premenopausal (20-39 yr) adult women during the follicular phase of the menstrual cycle. Subjects (11 control, 10 experimental) performed upright cycle ergometer exercise at 60% of maximal O2 consumption in a neutral environment (25°C, 30% relative humidity) for 20 min. Subjects were given placebo (P) or β-estradiol (2 mg/tablet, 3 tablets/day for 3 days). All experiments were conducted between 6:30 and 9:00 AM after ingestion of the last tablet. Heart rate, forearm blood flow (FBF), mean skin temperature, esophageal temperature (T(es)), and forearm sweat rate were measured. Blood analysis for estrogen and progesterone reflected the follicular phase of the menstrual cycle. Maximal O2 consumption (37.1 ± 6.2 in P vs. 38.4 ± 6.3 ml · kg-1 · min-1 in ES) and body weight-to-surface area ratio (35.58 ± 2.85 in P vs. 37.3 ± 2.7 in ES) were similar between groups. Synthesis of 70-kDa heat shock protein was not induced by 3 days of ES. Neither the threshold for sweating (36.97 ± 0.15 in P vs. 36.90 ± 0.22°C in ES), the threshold for an increase in FBF (37.09 ± 0.22 in P vs. 37.17 ± 0.26°C in ES), the slope of sweat rate- T(es) relationship (0.42 ± 0.16 in P vs. 0.41 ± 0.17 in ES), nor the FBF- T(es) relationship (10.04 ± 4.4 in P vs. 9.61 ± 3.46 in ES) was affected (P > 0.05) by 3 days of ES. We conclude that 3 days of ES by young adult women in the follicular phase of their menstrual cycle have no effect on heat transfer to the skin, heat dissipation by evaporative cooling, or leukocyte synthesis of 70-kDa heat shock protein.
AB - This study examined the effects of 3 days of estrogen supplementation (ES) on thermoregulation during exercise in premenopausal (20-39 yr) adult women during the follicular phase of the menstrual cycle. Subjects (11 control, 10 experimental) performed upright cycle ergometer exercise at 60% of maximal O2 consumption in a neutral environment (25°C, 30% relative humidity) for 20 min. Subjects were given placebo (P) or β-estradiol (2 mg/tablet, 3 tablets/day for 3 days). All experiments were conducted between 6:30 and 9:00 AM after ingestion of the last tablet. Heart rate, forearm blood flow (FBF), mean skin temperature, esophageal temperature (T(es)), and forearm sweat rate were measured. Blood analysis for estrogen and progesterone reflected the follicular phase of the menstrual cycle. Maximal O2 consumption (37.1 ± 6.2 in P vs. 38.4 ± 6.3 ml · kg-1 · min-1 in ES) and body weight-to-surface area ratio (35.58 ± 2.85 in P vs. 37.3 ± 2.7 in ES) were similar between groups. Synthesis of 70-kDa heat shock protein was not induced by 3 days of ES. Neither the threshold for sweating (36.97 ± 0.15 in P vs. 36.90 ± 0.22°C in ES), the threshold for an increase in FBF (37.09 ± 0.22 in P vs. 37.17 ± 0.26°C in ES), the slope of sweat rate- T(es) relationship (0.42 ± 0.16 in P vs. 0.41 ± 0.17 in ES), nor the FBF- T(es) relationship (10.04 ± 4.4 in P vs. 9.61 ± 3.46 in ES) was affected (P > 0.05) by 3 days of ES. We conclude that 3 days of ES by young adult women in the follicular phase of their menstrual cycle have no effect on heat transfer to the skin, heat dissipation by evaporative cooling, or leukocyte synthesis of 70-kDa heat shock protein.
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M3 - Article
C2 - 9843529
AN - SCOPUS:0031736724
VL - 85
SP - 2082
EP - 2088
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 6
ER -