Effect of estrogen supplementation on exercise thermoregulation in premenopausal women

R. T. Chang, G. Patrick Lambert, P. L. Moseley, F. K. Chapler, C. V. Gisolfi

Research output: Contribution to journalArticle

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Abstract

This study examined the effects of 3 days of estrogen supplementation (ES) on thermoregulation during exercise in premenopausal (20-39 yr) adult women during the follicular phase of the menstrual cycle. Subjects (11 control, 10 experimental) performed upright cycle ergometer exercise at 60% of maximal O2 consumption in a neutral environment (25°C, 30% relative humidity) for 20 min. Subjects were given placebo (P) or β-estradiol (2 mg/tablet, 3 tablets/day for 3 days). All experiments were conducted between 6:30 and 9:00 AM after ingestion of the last tablet. Heart rate, forearm blood flow (FBF), mean skin temperature, esophageal temperature (T(es)), and forearm sweat rate were measured. Blood analysis for estrogen and progesterone reflected the follicular phase of the menstrual cycle. Maximal O2 consumption (37.1 ± 6.2 in P vs. 38.4 ± 6.3 ml · kg-1 · min-1 in ES) and body weight-to-surface area ratio (35.58 ± 2.85 in P vs. 37.3 ± 2.7 in ES) were similar between groups. Synthesis of 70-kDa heat shock protein was not induced by 3 days of ES. Neither the threshold for sweating (36.97 ± 0.15 in P vs. 36.90 ± 0.22°C in ES), the threshold for an increase in FBF (37.09 ± 0.22 in P vs. 37.17 ± 0.26°C in ES), the slope of sweat rate- T(es) relationship (0.42 ± 0.16 in P vs. 0.41 ± 0.17 in ES), nor the FBF- T(es) relationship (10.04 ± 4.4 in P vs. 9.61 ± 3.46 in ES) was affected (P > 0.05) by 3 days of ES. We conclude that 3 days of ES by young adult women in the follicular phase of their menstrual cycle have no effect on heat transfer to the skin, heat dissipation by evaporative cooling, or leukocyte synthesis of 70-kDa heat shock protein.

Original languageEnglish (US)
Pages (from-to)2082-2088
Number of pages7
JournalJournal of Applied Physiology
Volume85
Issue number6
StatePublished - Dec 1 1998
Externally publishedYes

Fingerprint

Body Temperature Regulation
Estrogens
Exercise
Forearm
Follicular Phase
Tablets
HSP70 Heat-Shock Proteins
Sweat
Hot Temperature
Sweating
Skin Temperature
Humidity
Progesterone
Young Adult
Estradiol
Leukocytes
Eating
Heart Rate
Placebos
Body Weight

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Chang, R. T., Lambert, G. P., Moseley, P. L., Chapler, F. K., & Gisolfi, C. V. (1998). Effect of estrogen supplementation on exercise thermoregulation in premenopausal women. Journal of Applied Physiology, 85(6), 2082-2088.

Effect of estrogen supplementation on exercise thermoregulation in premenopausal women. / Chang, R. T.; Lambert, G. Patrick; Moseley, P. L.; Chapler, F. K.; Gisolfi, C. V.

In: Journal of Applied Physiology, Vol. 85, No. 6, 01.12.1998, p. 2082-2088.

Research output: Contribution to journalArticle

Chang, RT, Lambert, GP, Moseley, PL, Chapler, FK & Gisolfi, CV 1998, 'Effect of estrogen supplementation on exercise thermoregulation in premenopausal women', Journal of Applied Physiology, vol. 85, no. 6, pp. 2082-2088.
Chang, R. T. ; Lambert, G. Patrick ; Moseley, P. L. ; Chapler, F. K. ; Gisolfi, C. V. / Effect of estrogen supplementation on exercise thermoregulation in premenopausal women. In: Journal of Applied Physiology. 1998 ; Vol. 85, No. 6. pp. 2082-2088.
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abstract = "This study examined the effects of 3 days of estrogen supplementation (ES) on thermoregulation during exercise in premenopausal (20-39 yr) adult women during the follicular phase of the menstrual cycle. Subjects (11 control, 10 experimental) performed upright cycle ergometer exercise at 60{\%} of maximal O2 consumption in a neutral environment (25°C, 30{\%} relative humidity) for 20 min. Subjects were given placebo (P) or β-estradiol (2 mg/tablet, 3 tablets/day for 3 days). All experiments were conducted between 6:30 and 9:00 AM after ingestion of the last tablet. Heart rate, forearm blood flow (FBF), mean skin temperature, esophageal temperature (T(es)), and forearm sweat rate were measured. Blood analysis for estrogen and progesterone reflected the follicular phase of the menstrual cycle. Maximal O2 consumption (37.1 ± 6.2 in P vs. 38.4 ± 6.3 ml · kg-1 · min-1 in ES) and body weight-to-surface area ratio (35.58 ± 2.85 in P vs. 37.3 ± 2.7 in ES) were similar between groups. Synthesis of 70-kDa heat shock protein was not induced by 3 days of ES. Neither the threshold for sweating (36.97 ± 0.15 in P vs. 36.90 ± 0.22°C in ES), the threshold for an increase in FBF (37.09 ± 0.22 in P vs. 37.17 ± 0.26°C in ES), the slope of sweat rate- T(es) relationship (0.42 ± 0.16 in P vs. 0.41 ± 0.17 in ES), nor the FBF- T(es) relationship (10.04 ± 4.4 in P vs. 9.61 ± 3.46 in ES) was affected (P > 0.05) by 3 days of ES. We conclude that 3 days of ES by young adult women in the follicular phase of their menstrual cycle have no effect on heat transfer to the skin, heat dissipation by evaporative cooling, or leukocyte synthesis of 70-kDa heat shock protein.",
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