Effect of estrogens and calcium carbonate on bone loss in postmenopausal women

R. R. Recker, P. D. Saville, R. P. Heaney

Research output: Contribution to journalArticlepeer-review

388 Scopus citations


Sixty postmenopausal women were placed in three groups - control, sex hormone-treated, and CaCO3-treated - and followed for 2 years. Skeletal mass decreased by 1.18%/year in the control group, 0.15%/year in the hormone group, and 0.22%/year in the CaCO3 group by radiogrammetry; and 2.88%/year in the control group, 0.73%/year in the hormone group, and 1.83%/year in the CaCO3 group by photon absorptiometry. The treatment groups differed significantly from the control group except for photon absorptiometry in the CaCO3 group. Bone accretion and resorption decreased in the treatment groups as measured by calcium tracer kinetics, resorption more so than accretion. The authors conclude that [1] these techniques are sufficiently sensitive to detect age-related bone loss; [2] postmenopausal sex-hormone replacement measurably decreases age-related bone loss by suppressing bone turnover, resorption more than accretion; and [3] calcium supplements produce the same effect but at the dose the authors used were slightly less effective.

Original languageEnglish (US)
Pages (from-to)649-655
Number of pages7
JournalAnnals of internal medicine
Issue number6
StatePublished - Jan 1 1977

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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