Effect of hydrochlorothiazide on phosphorus during treatment with diphosphonate

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Abstract

The effects of probenecid and hydrochlorothiazide on renal handling of phosphorus during hyperphosphatemia induced by diphosphonate (ethane- 1-hydroxy-1, 1-diphosphonate, EHDP) was studied. Measurements of calcium, phosphorus, and creatinine clearance were performed in 2 sessions on each of 3 consecutive days in 10 normal fasting volunteers during the morning hours from 8 A. M. to 12 noon. During 2 to 3 wk thereafter, each subject was treated with EHDP, 30 mg/kg/day. The second group of studies were performed in the same manner as the first except that EHDP administration was continued throughout. EHDP caused elevation of serum phosphorus in all cases. Probenecid did not affect urine phosphorus. Hydrochlorothiazide caused a transient phosphaturia of similar magnitude in the EHDP treated and untreated states. Creatinine clearance was not affected by any of the treatments and urine calcium was decreased by EHDP. It was concluded that hydrochlorothiazide inhibits tubular reabsorption of phosphorus but that it does not affect the mechanism whereby EHDP causes increased tubular reabsorption of phosphorus. Chronic administration of hydrochlorothiazide along with EHDP may inhibit hyperphosphatemia and may change the bone effects of EHDP.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalClinical Pharmacology and Therapeutics
Volume18
Issue number3
StatePublished - Sep 1975

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Hydrochlorothiazide
Diphosphonates
Ethane
Phosphorus
Hyperphosphatemia
Therapeutics
Probenecid
Creatinine
Familial Hypophosphatemia
Urine
Calcium
Fasting
Healthy Volunteers
Kidney
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Effect of hydrochlorothiazide on phosphorus during treatment with diphosphonate. / Recker, Robert R.

In: Clinical Pharmacology and Therapeutics, Vol. 18, No. 3, 09.1975, p. 345-349.

Research output: Contribution to journalArticle

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