Effect of hydroxycitric acid on serotonin release from isolated rat brain cortex

S. E. Ohia; S. O. Awe; A. M. LeDay; C. A. Opere; D. Bagchi

Effect of hydroxycitric acid on serotonin release from isolated rat brain cortex

S. E. Ohia, S. O. Awe, A. M. LeDay, C. A. Opere, D. Bagchi

Department of Pharmacy Sciences

Research output: Contribution to journal › Article

41 Scopus citations

Abstract

There is evidence that hydroxycitric acid (HCA), an extract of dried fruit rind of South Asian trees of the genus Garcinia cambogia, can reduce food intake in experimental animals. In the present study, we investigated the effect of HCA on basal and potassiumdepolarization evoked increase in radiolabeled serotonin ([³H]-5-HT) release from rat brain cortex slices in vitro. HCA (10 μM-1 mM) altered the baseline of spontaneous tritium efflux but had no significant effect on potassium-evoked release of [³H]-5-HT. When applied on its own, HCA (10 μM-1 mM) elicited a concentration-dependent increase in efflux of [³H]-5-HT reaching a maximum at 300 μM. We conclude that HCA can increase the release of radiolabeled 5-HT from the isolated rat brain cortex.

Original language	English (US)
Pages (from-to)	210-216
Number of pages	7
Journal	Research Communications in Molecular Pathology and Pharmacology
Volume	109
Issue number	3-4
State	Published - Dec 10 2001

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology

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Ohia, S. E., Awe, S. O., LeDay, A. M., Opere, C. A., & Bagchi, D. (2001). Effect of hydroxycitric acid on serotonin release from isolated rat brain cortex. Research Communications in Molecular Pathology and Pharmacology, 109(3-4), 210-216.

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AU - Awe, S. O.

AU - LeDay, A. M.

AU - Opere, C. A.

AU - Bagchi, D.

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AB - There is evidence that hydroxycitric acid (HCA), an extract of dried fruit rind of South Asian trees of the genus Garcinia cambogia, can reduce food intake in experimental animals. In the present study, we investigated the effect of HCA on basal and potassiumdepolarization evoked increase in radiolabeled serotonin ([3H]-5-HT) release from rat brain cortex slices in vitro. HCA (10 μM-1 mM) altered the baseline of spontaneous tritium efflux but had no significant effect on potassium-evoked release of [3H]-5-HT. When applied on its own, HCA (10 μM-1 mM) elicited a concentration-dependent increase in efflux of [3H]-5-HT reaching a maximum at 300 μM. We conclude that HCA can increase the release of radiolabeled 5-HT from the isolated rat brain cortex.

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