Abstract
There is evidence that hydroxycitric acid (HCA), an extract of dried fruit rind of South Asian trees of the genus Garcinia cambogia, can reduce food intake in experimental animals. In the present study, we investigated the effect of HCA on basal and potassiumdepolarization evoked increase in radiolabeled serotonin ([3H]-5-HT) release from rat brain cortex slices in vitro. HCA (10 μM-1 mM) altered the baseline of spontaneous tritium efflux but had no significant effect on potassium-evoked release of [3H]-5-HT. When applied on its own, HCA (10 μM-1 mM) elicited a concentration-dependent increase in efflux of [3H]-5-HT reaching a maximum at 300 μM. We conclude that HCA can increase the release of radiolabeled 5-HT from the isolated rat brain cortex.
| Original language | English |
|---|---|
| Pages (from-to) | 210-216 |
| Number of pages | 7 |
| Journal | Research Communications in Molecular Pathology and Pharmacology |
| Volume | 109 |
| Issue number | 3-4 |
| State | Published - 2001 |
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All Science Journal Classification (ASJC) codes
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pathology and Forensic Medicine
Cite this
Effect of hydroxycitric acid on serotonin release from isolated rat brain cortex. / Ohia, S. E.; Awe, S. O.; LeDay, A. M.; Opere, Catherine A.; Bagchi, D.
In: Research Communications in Molecular Pathology and Pharmacology, Vol. 109, No. 3-4, 2001, p. 210-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of hydroxycitric acid on serotonin release from isolated rat brain cortex
AU - Ohia, S. E.
AU - Awe, S. O.
AU - LeDay, A. M.
AU - Opere, Catherine A.
AU - Bagchi, D.
PY - 2001
Y1 - 2001
N2 - There is evidence that hydroxycitric acid (HCA), an extract of dried fruit rind of South Asian trees of the genus Garcinia cambogia, can reduce food intake in experimental animals. In the present study, we investigated the effect of HCA on basal and potassiumdepolarization evoked increase in radiolabeled serotonin ([3H]-5-HT) release from rat brain cortex slices in vitro. HCA (10 μM-1 mM) altered the baseline of spontaneous tritium efflux but had no significant effect on potassium-evoked release of [3H]-5-HT. When applied on its own, HCA (10 μM-1 mM) elicited a concentration-dependent increase in efflux of [3H]-5-HT reaching a maximum at 300 μM. We conclude that HCA can increase the release of radiolabeled 5-HT from the isolated rat brain cortex.
AB - There is evidence that hydroxycitric acid (HCA), an extract of dried fruit rind of South Asian trees of the genus Garcinia cambogia, can reduce food intake in experimental animals. In the present study, we investigated the effect of HCA on basal and potassiumdepolarization evoked increase in radiolabeled serotonin ([3H]-5-HT) release from rat brain cortex slices in vitro. HCA (10 μM-1 mM) altered the baseline of spontaneous tritium efflux but had no significant effect on potassium-evoked release of [3H]-5-HT. When applied on its own, HCA (10 μM-1 mM) elicited a concentration-dependent increase in efflux of [3H]-5-HT reaching a maximum at 300 μM. We conclude that HCA can increase the release of radiolabeled 5-HT from the isolated rat brain cortex.
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M3 - Article
VL - 109
SP - 210
EP - 216
JO - Research Communications in Molecular Pathology and Pharmacology
JF - Research Communications in Molecular Pathology and Pharmacology
SN - 1078-0297
IS - 3-4
ER -