Abstract
Inhaled furosemide has been recently demonstrated to inhibit the bronchoconstrictive effects of exercise, ultrasonically nebulized distilled water, and antigen challenge. The presumed mechanism of action of these challenges is through mast cell degranulation. We report on the effect of inhaled furosemide on cold-air hyperventilation challenge (CAHC) and methacholine challenge. We studied 10 subjects with mild to moderate asthma in a double-blind, placebo-controlled, crossover study. Inhaled furosemide did not affect FEV1 in the hour after inhalation, and there was no significant difference between placebo or furosemide on the dose of methacholine causing a 20% fall in FEV1. Our results demonstrated inhaled furosemide significantly attenuated the bronchoconstrictive effect at 6 and 9 minutes after CAHC (p <0.05 and 0.029, respectively) when furosemide was compared to placebo and approached significance at 12 and 15 minutes after CAHC (p = 0.052 and 0.56, respectively). Inhaled furosemide attenuates CAHC but does not effect methacholine-induced bronchoconstriction.
| Original language | English |
|---|---|
| Pages (from-to) | 881-884 |
| Number of pages | 4 |
| Journal | Journal of Allergy and Clinical Immunology |
| Volume | 85 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1990 |
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All Science Journal Classification (ASJC) codes
- Immunology
- Immunology and Allergy
Cite this
Effect of inhaled furosemide on the bronchial response to methacholine and cold-air hyperventilation challenges. / Grubbe, Robert E.; Hopp, Russell; Dave, Nikhil K.; Brennan, Brian; Bewtra, Againdra K.; Townley, Robert.
In: Journal of Allergy and Clinical Immunology, Vol. 85, No. 5, 1990, p. 881-884.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of inhaled furosemide on the bronchial response to methacholine and cold-air hyperventilation challenges
AU - Grubbe, Robert E.
AU - Hopp, Russell
AU - Dave, Nikhil K.
AU - Brennan, Brian
AU - Bewtra, Againdra K.
AU - Townley, Robert
PY - 1990
Y1 - 1990
N2 - Inhaled furosemide has been recently demonstrated to inhibit the bronchoconstrictive effects of exercise, ultrasonically nebulized distilled water, and antigen challenge. The presumed mechanism of action of these challenges is through mast cell degranulation. We report on the effect of inhaled furosemide on cold-air hyperventilation challenge (CAHC) and methacholine challenge. We studied 10 subjects with mild to moderate asthma in a double-blind, placebo-controlled, crossover study. Inhaled furosemide did not affect FEV1 in the hour after inhalation, and there was no significant difference between placebo or furosemide on the dose of methacholine causing a 20% fall in FEV1. Our results demonstrated inhaled furosemide significantly attenuated the bronchoconstrictive effect at 6 and 9 minutes after CAHC (p <0.05 and 0.029, respectively) when furosemide was compared to placebo and approached significance at 12 and 15 minutes after CAHC (p = 0.052 and 0.56, respectively). Inhaled furosemide attenuates CAHC but does not effect methacholine-induced bronchoconstriction.
AB - Inhaled furosemide has been recently demonstrated to inhibit the bronchoconstrictive effects of exercise, ultrasonically nebulized distilled water, and antigen challenge. The presumed mechanism of action of these challenges is through mast cell degranulation. We report on the effect of inhaled furosemide on cold-air hyperventilation challenge (CAHC) and methacholine challenge. We studied 10 subjects with mild to moderate asthma in a double-blind, placebo-controlled, crossover study. Inhaled furosemide did not affect FEV1 in the hour after inhalation, and there was no significant difference between placebo or furosemide on the dose of methacholine causing a 20% fall in FEV1. Our results demonstrated inhaled furosemide significantly attenuated the bronchoconstrictive effect at 6 and 9 minutes after CAHC (p <0.05 and 0.029, respectively) when furosemide was compared to placebo and approached significance at 12 and 15 minutes after CAHC (p = 0.052 and 0.56, respectively). Inhaled furosemide attenuates CAHC but does not effect methacholine-induced bronchoconstriction.
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U2 - 10.1016/0091-6749(90)90072-C
DO - 10.1016/0091-6749(90)90072-C
M3 - Article
C2 - 2332565
AN - SCOPUS:0025301312
VL - 85
SP - 881
EP - 884
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 5
ER -