Effect of JP-8 jet fuel exposure on the ultrastructure of skin

Somnath Singh, J. Singh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Fuel system maintenance usually requires direct, prolonged exposure to fuel. Thus, both military and commercial aircraft workers are at risk of dermal exposure and toxicity from JP-8 jet fuel. At present, there are no standards for U.S. Air Force personnel regarding dermal exposure to jet fuel. Hence, there are needs for data and approaches to understand the human hazard from dermal exposure to JP-8. In this study, we investigated the alteration in porcine skin at ultrastructural level, after a 24-h exposure to JP-8, with the help of transmission electron microscopy (TEM). Many ultrastructural modifications were noticed in the photomicrographs. Large-scale expansion in intercellular lipid domains of stratum corneum and disruption in its structural integrity; alteration in configuration of basal cells; rupture of hemidesmosomes and desmosomes; and diminished dendritic processes in Langerhans cells were observed. It is concluded that JP-8 exposure can cause alteration in skin anatomy, which may lead to dermal toxicity. Further studies are required to determine comparative damages incurred by individual components of JP-8.

Original languageEnglish
Pages (from-to)11-21
Number of pages11
JournalJournal of Toxicology - Cutaneous and Ocular Toxicology
Volume20
Issue number1
DOIs
StatePublished - 2001

Fingerprint

Toxicity
Skin
Fuel systems
Jet fuel
Structural integrity
Hazards
Cells
Aircraft
Personnel
Transmission electron microscopy
Lipids
Air
Hemidesmosomes
Desmosomes
Langerhans Cells
Military Personnel
Transmission Electron Microscopy
Cornea
JP8 aviation fuel
Rupture

All Science Journal Classification (ASJC) codes

  • Health, Toxicology and Mutagenesis
  • Ophthalmology
  • Toxicology

Cite this

Effect of JP-8 jet fuel exposure on the ultrastructure of skin. / Singh, Somnath; Singh, J.

In: Journal of Toxicology - Cutaneous and Ocular Toxicology, Vol. 20, No. 1, 2001, p. 11-21.

Research output: Contribution to journalArticle

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