TY - JOUR
T1 - Effect of JP-8 jet fuel exposure on the ultrastructure of skin
AU - Singh, S.
AU - Singh, J.
N1 - Funding Information:
We would like to acknowledge the financial support from the U.S. Department of Defense, Air Force Office of Scientific Research Grant # F 49620-99-1-0223.
PY - 2001
Y1 - 2001
N2 - Fuel system maintenance usually requires direct, prolonged exposure to fuel. Thus, both military and commercial aircraft workers are at risk of dermal exposure and toxicity from JP-8 jet fuel. At present, there are no standards for U.S. Air Force personnel regarding dermal exposure to jet fuel. Hence, there are needs for data and approaches to understand the human hazard from dermal exposure to JP-8. In this study, we investigated the alteration in porcine skin at ultrastructural level, after a 24-h exposure to JP-8, with the help of transmission electron microscopy (TEM). Many ultrastructural modifications were noticed in the photomicrographs. Large-scale expansion in intercellular lipid domains of stratum corneum and disruption in its structural integrity; alteration in configuration of basal cells; rupture of hemidesmosomes and desmosomes; and diminished dendritic processes in Langerhans cells were observed. It is concluded that JP-8 exposure can cause alteration in skin anatomy, which may lead to dermal toxicity. Further studies are required to determine comparative damages incurred by individual components of JP-8.
AB - Fuel system maintenance usually requires direct, prolonged exposure to fuel. Thus, both military and commercial aircraft workers are at risk of dermal exposure and toxicity from JP-8 jet fuel. At present, there are no standards for U.S. Air Force personnel regarding dermal exposure to jet fuel. Hence, there are needs for data and approaches to understand the human hazard from dermal exposure to JP-8. In this study, we investigated the alteration in porcine skin at ultrastructural level, after a 24-h exposure to JP-8, with the help of transmission electron microscopy (TEM). Many ultrastructural modifications were noticed in the photomicrographs. Large-scale expansion in intercellular lipid domains of stratum corneum and disruption in its structural integrity; alteration in configuration of basal cells; rupture of hemidesmosomes and desmosomes; and diminished dendritic processes in Langerhans cells were observed. It is concluded that JP-8 exposure can cause alteration in skin anatomy, which may lead to dermal toxicity. Further studies are required to determine comparative damages incurred by individual components of JP-8.
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U2 - 10.1081/CUS-100000336
DO - 10.1081/CUS-100000336
M3 - Article
AN - SCOPUS:0035103516
VL - 20
SP - 11
EP - 21
JO - Cutaneous and Ocular Toxicology
JF - Cutaneous and Ocular Toxicology
SN - 1556-9527
IS - 1
ER -