Effect of lodoxamide on the secretory response induced by Escherichia coli and Vibrio cholerae enterotoxins in infant mice

Floyd C. Knoop, D. D. Thomas

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of lodoxamide tromethamine, a calcium antagonist, on intestinal fluid accumulation induced by Escherichia coli heat-stable (ST) and Vibrio cholerae (CT) enterotoxins in infant mice was investigated. The simultaneous administration of lodoxamide with ST and CT enterotoxin resulted in a significant (P < 0.01) inhibition of the intestinal fluid response. A minimum concentration of 10-7 or 10-8 M lodoxamide caused an inhibition (P < 0.01) of the ST- or CT-mediated fluid response, respectively. Treatment of infant mice with buffer or drug alone did not result in fluid accumulation. A significant inhibition of ST and CT enterotoxic activities was also observed when lodoxamide was administered 30 min before (P < 0.02) or 30 min after (P < 0.01) toxin challenge. These data suggest that calcium may be important in the ST- or CT-mediated induction of fluid accumulation. Further studies on the potential use of lodoxamide tromethamine in both the prophylaxis and treatment of diarrheal disease appear warranted.

Original languageEnglish (US)
Pages (from-to)406-408
Number of pages3
JournalInfection and Immunity
Volume44
Issue number2
StatePublished - Jan 1 1984

Fingerprint

Vibrio cholerae
Escherichia coli
Calcium
Enterotoxins
Buffers
Hot Temperature
Therapeutics
Pharmaceutical Preparations
lodoxamide ethyl
Vibrio cholerae stN protein
lodoxamide tromethamine

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Effect of lodoxamide on the secretory response induced by Escherichia coli and Vibrio cholerae enterotoxins in infant mice. / Knoop, Floyd C.; Thomas, D. D.

In: Infection and Immunity, Vol. 44, No. 2, 01.01.1984, p. 406-408.

Research output: Contribution to journalArticle

@article{6bfa00e47cd6417dba019ca1ce91461b,
title = "Effect of lodoxamide on the secretory response induced by Escherichia coli and Vibrio cholerae enterotoxins in infant mice",
abstract = "The effect of lodoxamide tromethamine, a calcium antagonist, on intestinal fluid accumulation induced by Escherichia coli heat-stable (ST) and Vibrio cholerae (CT) enterotoxins in infant mice was investigated. The simultaneous administration of lodoxamide with ST and CT enterotoxin resulted in a significant (P < 0.01) inhibition of the intestinal fluid response. A minimum concentration of 10-7 or 10-8 M lodoxamide caused an inhibition (P < 0.01) of the ST- or CT-mediated fluid response, respectively. Treatment of infant mice with buffer or drug alone did not result in fluid accumulation. A significant inhibition of ST and CT enterotoxic activities was also observed when lodoxamide was administered 30 min before (P < 0.02) or 30 min after (P < 0.01) toxin challenge. These data suggest that calcium may be important in the ST- or CT-mediated induction of fluid accumulation. Further studies on the potential use of lodoxamide tromethamine in both the prophylaxis and treatment of diarrheal disease appear warranted.",
author = "Knoop, {Floyd C.} and Thomas, {D. D.}",
year = "1984",
month = "1",
day = "1",
language = "English (US)",
volume = "44",
pages = "406--408",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "2",

}

TY - JOUR

T1 - Effect of lodoxamide on the secretory response induced by Escherichia coli and Vibrio cholerae enterotoxins in infant mice

AU - Knoop, Floyd C.

AU - Thomas, D. D.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - The effect of lodoxamide tromethamine, a calcium antagonist, on intestinal fluid accumulation induced by Escherichia coli heat-stable (ST) and Vibrio cholerae (CT) enterotoxins in infant mice was investigated. The simultaneous administration of lodoxamide with ST and CT enterotoxin resulted in a significant (P < 0.01) inhibition of the intestinal fluid response. A minimum concentration of 10-7 or 10-8 M lodoxamide caused an inhibition (P < 0.01) of the ST- or CT-mediated fluid response, respectively. Treatment of infant mice with buffer or drug alone did not result in fluid accumulation. A significant inhibition of ST and CT enterotoxic activities was also observed when lodoxamide was administered 30 min before (P < 0.02) or 30 min after (P < 0.01) toxin challenge. These data suggest that calcium may be important in the ST- or CT-mediated induction of fluid accumulation. Further studies on the potential use of lodoxamide tromethamine in both the prophylaxis and treatment of diarrheal disease appear warranted.

AB - The effect of lodoxamide tromethamine, a calcium antagonist, on intestinal fluid accumulation induced by Escherichia coli heat-stable (ST) and Vibrio cholerae (CT) enterotoxins in infant mice was investigated. The simultaneous administration of lodoxamide with ST and CT enterotoxin resulted in a significant (P < 0.01) inhibition of the intestinal fluid response. A minimum concentration of 10-7 or 10-8 M lodoxamide caused an inhibition (P < 0.01) of the ST- or CT-mediated fluid response, respectively. Treatment of infant mice with buffer or drug alone did not result in fluid accumulation. A significant inhibition of ST and CT enterotoxic activities was also observed when lodoxamide was administered 30 min before (P < 0.02) or 30 min after (P < 0.01) toxin challenge. These data suggest that calcium may be important in the ST- or CT-mediated induction of fluid accumulation. Further studies on the potential use of lodoxamide tromethamine in both the prophylaxis and treatment of diarrheal disease appear warranted.

UR - http://www.scopus.com/inward/record.url?scp=0021340334&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021340334&partnerID=8YFLogxK

M3 - Article

C2 - 6143729

AN - SCOPUS:0021340334

VL - 44

SP - 406

EP - 408

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 2

ER -