Effect of loratadine on human eosinophil function in vitro

R. Eda, H. Sugiyama, R. J. Hopp, A. K. Bewtra, R. G. Townley

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Abstract

We investigated the in vitro effect of loratadine, a new nonsedating H1 histamine antagonist, on the eosinophil functions of chemotaxis, superoxide anion (O2-) generation and eosinophil cationic protein (ECP) release, using purified eosinophils obtained from allergic patients. Loratadine significantly attenuated platelet-activating factor (PAF)-induced eosinophil chemotaxis and O2- generation at therapeutic concentrations (equivalent to serum concentrations after single oral administration of 20 mg or 40 mg). Loratadine, however, had no effect on PAF-induced ECP release. These findings suggest that loratadine has a direct inhibitory effect on eosinophil activation and may be beneficial in the therapy of allergic disorders with its anti-allergic properties.

Original languageEnglish (US)
Pages (from-to)373-378
Number of pages6
JournalAnnals of allergy
Volume71
Issue number4
StatePublished - 1993

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

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    Eda, R., Sugiyama, H., Hopp, R. J., Bewtra, A. K., & Townley, R. G. (1993). Effect of loratadine on human eosinophil function in vitro. Annals of allergy, 71(4), 373-378.