Effect of loratadine on human eosinophil function in vitro

R. Eda, H. Sugiyama, R. J. Hopp, Againdra K. Bewtra, R. G. Townley

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

We investigated the in vitro effect of loratadine, a new nonsedating H1 histamine antagonist, on the eosinophil functions of chemotaxis, superoxide anion (O2-) generation and eosinophil cationic protein (ECP) release, using purified eosinophils obtained from allergic patients. Loratadine significantly attenuated platelet-activating factor (PAF)-induced eosinophil chemotaxis and O2- generation at therapeutic concentrations (equivalent to serum concentrations after single oral administration of 20 mg or 40 mg). Loratadine, however, had no effect on PAF-induced ECP release. These findings suggest that loratadine has a direct inhibitory effect on eosinophil activation and may be beneficial in the therapy of allergic disorders with its anti-allergic properties.

Original languageEnglish
Pages (from-to)373-378
Number of pages6
JournalAnnals of Allergy
Volume71
Issue number4
StatePublished - 1993

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Loratadine
Eosinophils
Eosinophil Cationic Protein
Platelet Activating Factor
Chemotaxis
Histamine H1 Antagonists
Anti-Allergic Agents
Superoxides
Oral Administration
In Vitro Techniques
Therapeutics
Serum

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

Cite this

Eda, R., Sugiyama, H., Hopp, R. J., Bewtra, A. K., & Townley, R. G. (1993). Effect of loratadine on human eosinophil function in vitro. Annals of Allergy, 71(4), 373-378.

Effect of loratadine on human eosinophil function in vitro. / Eda, R.; Sugiyama, H.; Hopp, R. J.; Bewtra, Againdra K.; Townley, R. G.

In: Annals of Allergy, Vol. 71, No. 4, 1993, p. 373-378.

Research output: Contribution to journalArticle

Eda, R, Sugiyama, H, Hopp, RJ, Bewtra, AK & Townley, RG 1993, 'Effect of loratadine on human eosinophil function in vitro', Annals of Allergy, vol. 71, no. 4, pp. 373-378.
Eda R, Sugiyama H, Hopp RJ, Bewtra AK, Townley RG. Effect of loratadine on human eosinophil function in vitro. Annals of Allergy. 1993;71(4):373-378.
Eda, R. ; Sugiyama, H. ; Hopp, R. J. ; Bewtra, Againdra K. ; Townley, R. G. / Effect of loratadine on human eosinophil function in vitro. In: Annals of Allergy. 1993 ; Vol. 71, No. 4. pp. 373-378.
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