Abstract
The effect of penetration enhancer (i.e., 1, 2, 3 and 5% menthone in combination with 50% ethanol (EtOH)) was investigated on the in vitro percutaneous absorption of tamoxifen, and post-recovery epidermal permeability after removal of the above enhancer. The flux of tamoxifen with menthone in combination with 50% EtOH was significantly greater (P <0.05) than the control (50% EtOH). The flux of tamoxifen increased with increasing concentrations of menthone. The post-recovery flux through enhancer exposed epidermis was significantly decreased (P <0.05) as compared to pre-recovery. However, post-recovery flux of tamoxifen through the enhancer-exposed epidermis did not completely recover to the baseline (i.e., post-recovery flux through phosphate buffered saline, pH 7.4 treated epidermis).
| Original language | English |
|---|---|
| Pages (from-to) | 177-181 |
| Number of pages | 5 |
| Journal | International Journal of Pharmaceutics |
| Volume | 219 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - May 21 2001 |
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All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
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Effect of menthone on the in vitro percutaneous absorption of tamoxifen and skin reversibility. / Zhao, Kaidi; Singh, Somnath; Singh, Jagdish.
In: International Journal of Pharmaceutics, Vol. 219, No. 1-2, 21.05.2001, p. 177-181.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of menthone on the in vitro percutaneous absorption of tamoxifen and skin reversibility
AU - Zhao, Kaidi
AU - Singh, Somnath
AU - Singh, Jagdish
PY - 2001/5/21
Y1 - 2001/5/21
N2 - The effect of penetration enhancer (i.e., 1, 2, 3 and 5% menthone in combination with 50% ethanol (EtOH)) was investigated on the in vitro percutaneous absorption of tamoxifen, and post-recovery epidermal permeability after removal of the above enhancer. The flux of tamoxifen with menthone in combination with 50% EtOH was significantly greater (P <0.05) than the control (50% EtOH). The flux of tamoxifen increased with increasing concentrations of menthone. The post-recovery flux through enhancer exposed epidermis was significantly decreased (P <0.05) as compared to pre-recovery. However, post-recovery flux of tamoxifen through the enhancer-exposed epidermis did not completely recover to the baseline (i.e., post-recovery flux through phosphate buffered saline, pH 7.4 treated epidermis).
AB - The effect of penetration enhancer (i.e., 1, 2, 3 and 5% menthone in combination with 50% ethanol (EtOH)) was investigated on the in vitro percutaneous absorption of tamoxifen, and post-recovery epidermal permeability after removal of the above enhancer. The flux of tamoxifen with menthone in combination with 50% EtOH was significantly greater (P <0.05) than the control (50% EtOH). The flux of tamoxifen increased with increasing concentrations of menthone. The post-recovery flux through enhancer exposed epidermis was significantly decreased (P <0.05) as compared to pre-recovery. However, post-recovery flux of tamoxifen through the enhancer-exposed epidermis did not completely recover to the baseline (i.e., post-recovery flux through phosphate buffered saline, pH 7.4 treated epidermis).
UR - http://www.scopus.com/inward/record.url?scp=0035927198&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035927198&partnerID=8YFLogxK
U2 - 10.1016/S0378-5173(01)00640-8
DO - 10.1016/S0378-5173(01)00640-8
M3 - Article
VL - 219
SP - 177
EP - 181
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-2
ER -