Effect of mitral regurgitation on cerebrovascular accidents in patients with atrial fibrillation and left atrial thrombus

Chandra K. Nair, Wilbert S. Aronow, Xuedong Shen, Kishlay Anand, Mark Jeffrey Holmberg, Dennis J. Esterbrooks

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The effect of mitral regurgitation (MR) on the incidence of new cerebrovascular accidents (CVA) and mortality in patients with atrial fibrillation (AF) and left atrial thrombus (LAT) is unknown. Objective: To investigate the effect of MR in patients with AF and LAT on new CVA and mortality. Methods: Eighty nine consecutive patients, mean age 71 years, with AF and LAT documented by transesophageal echocardiography were investigated to determine the prevalence and severity of MR and the association of the severity of MR with new cerebrovascular accidents (CVA) and mortality at 34-mo follow-up. Results: Of 89 patients, 1+ MR was present in 23 patients (26%), 2+ MR in 44 patients (50%), 3+ MR in 17 patients (19%), and 4+ MR in 3 patients (4%). Mean follow-up was 34±28 mo. The Cox proportional hazards model showed that the severity of increased MR did not significantly increase new CVA or mortality at 34-mo follow-up. The only variable predictive of mortality was left ventricular ejection fraction (LVEF), and with every unit increase in LVEF, the risk decreased by 3%. Conclusion: MR occurred in 87 of 89 patients (98%) with AF and LAT. There was no association between the severity of MR and the incidence of CVA or mortality.

Original languageEnglish
JournalClinical Cardiology
Volume32
Issue number11
DOIs
StatePublished - Nov 2009

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Mitral Valve Insufficiency
Atrial Fibrillation
Thrombosis
Stroke
Mortality
Stroke Volume
Transesophageal Echocardiography
Incidence
Proportional Hazards Models

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of mitral regurgitation on cerebrovascular accidents in patients with atrial fibrillation and left atrial thrombus. / Nair, Chandra K.; Aronow, Wilbert S.; Shen, Xuedong; Anand, Kishlay; Holmberg, Mark Jeffrey; Esterbrooks, Dennis J.

In: Clinical Cardiology, Vol. 32, No. 11, 11.2009.

Research output: Contribution to journalArticle

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AU - Aronow, Wilbert S.

AU - Shen, Xuedong

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AU - Holmberg, Mark Jeffrey

AU - Esterbrooks, Dennis J.

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