Effect of platelet-activating factor inhalation on nonspecific bronchial reactivity in man

R. J. Hopp, A. K. Bewtra, D. K. Agrawal, R. G. Townley

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9 Scopus citations

Abstract

Bronchial hyperactivity is a recognized hallmark of asthma, characterized by an exaggerated bronchial response to numerous mediators, including histamine. It is also well recognized that bronchial hyperresponsiveness is increased following allergen exposure, although no particular mediator has been shown to induce this response. The recent observation that PAF can induce increased nonspecific bronchial reactivity in normal subjects emphasizes its importance as an inflammatory mediator. In this report we sought to further elucidate the role of PAF in airway hyperreactivity by comparing the effect of PAF on methacholine-induced airway responsiveness in six non-asthmatic subjects. Nonspecific airway responsiveness was not significantly increased following PAF inhalation at 6 hours nor was it increased at 1, 2, 7, or 14 days. Further elucidation of the potential role of PAF in explaining changes in airway reactivity is necessary.

Original languageEnglish (US)
Pages (from-to)1070-1072
Number of pages3
JournalChest
Volume96
Issue number5
DOIs
StatePublished - Jan 1 1989

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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    Hopp, R. J., Bewtra, A. K., Agrawal, D. K., & Townley, R. G. (1989). Effect of platelet-activating factor inhalation on nonspecific bronchial reactivity in man. Chest, 96(5), 1070-1072. https://doi.org/10.1378/chest.96.5.1070