Abstract
PURPOSE: To measure changes and predictors of change in mammograms obtained in postmenopausal women undergoing continuous combined hormonal replacement therapy (HRT). MATERIALS AND METHODS: Mammograms of 41 postmenopausal women obtained before and 1 year after the initiation of HRT were evaluated blindly according to the quantitative density percentage method and the Wolfe classification system. RESULTS: Mammographic densities increased compared with baseline values in 73% of subjects (mean increase, 6.7%; 95% confidence interval, 2.5%, 11.0%; P = .003). A shift in Wolfe classification from lower to greater parenchymal density was noted in 24% of subjects (P = .016). Multivariate analysis results indicated that the lower the tissue density percentage before treatment, the greater the increase in density percentage after treatment. CONCLUSION: An increase in mammographic density was demonstrated in most subjects undergoing continuous combined HRT and was most pronounced in subjects with a lower baseline density percentage.
| Original language | English |
|---|---|
| Pages (from-to) | 433-437 |
| Number of pages | 5 |
| Journal | Radiology |
| Volume | 196 |
| Issue number | 2 |
| State | Published - Aug 1995 |
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All Science Journal Classification (ASJC) codes
- Radiological and Ultrasound Technology
Cite this
Effect of postmenopausal hormonal replacement therapy on mammographic density and parenchymal pattern. / Laya, Mary B.; Gallagher, John Christopher G.; Schreiman, Judith S.; Larson, Eric B.; Watson, Patrice; Weinstein, Louis.
In: Radiology, Vol. 196, No. 2, 08.1995, p. 433-437.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of postmenopausal hormonal replacement therapy on mammographic density and parenchymal pattern
AU - Laya, Mary B.
AU - Gallagher, John Christopher G.
AU - Schreiman, Judith S.
AU - Larson, Eric B.
AU - Watson, Patrice
AU - Weinstein, Louis
PY - 1995/8
Y1 - 1995/8
N2 - PURPOSE: To measure changes and predictors of change in mammograms obtained in postmenopausal women undergoing continuous combined hormonal replacement therapy (HRT). MATERIALS AND METHODS: Mammograms of 41 postmenopausal women obtained before and 1 year after the initiation of HRT were evaluated blindly according to the quantitative density percentage method and the Wolfe classification system. RESULTS: Mammographic densities increased compared with baseline values in 73% of subjects (mean increase, 6.7%; 95% confidence interval, 2.5%, 11.0%; P = .003). A shift in Wolfe classification from lower to greater parenchymal density was noted in 24% of subjects (P = .016). Multivariate analysis results indicated that the lower the tissue density percentage before treatment, the greater the increase in density percentage after treatment. CONCLUSION: An increase in mammographic density was demonstrated in most subjects undergoing continuous combined HRT and was most pronounced in subjects with a lower baseline density percentage.
AB - PURPOSE: To measure changes and predictors of change in mammograms obtained in postmenopausal women undergoing continuous combined hormonal replacement therapy (HRT). MATERIALS AND METHODS: Mammograms of 41 postmenopausal women obtained before and 1 year after the initiation of HRT were evaluated blindly according to the quantitative density percentage method and the Wolfe classification system. RESULTS: Mammographic densities increased compared with baseline values in 73% of subjects (mean increase, 6.7%; 95% confidence interval, 2.5%, 11.0%; P = .003). A shift in Wolfe classification from lower to greater parenchymal density was noted in 24% of subjects (P = .016). Multivariate analysis results indicated that the lower the tissue density percentage before treatment, the greater the increase in density percentage after treatment. CONCLUSION: An increase in mammographic density was demonstrated in most subjects undergoing continuous combined HRT and was most pronounced in subjects with a lower baseline density percentage.
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M3 - Article
VL - 196
SP - 433
EP - 437
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 2
ER -