Effect of postmenopausal hormonal replacement therapy on mammographic density and parenchymal pattern

Mary B. Laya, John Christopher G. Gallagher, Judith S. Schreiman, Eric B. Larson, Patrice Watson, Louis Weinstein

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

PURPOSE: To measure changes and predictors of change in mammograms obtained in postmenopausal women undergoing continuous combined hormonal replacement therapy (HRT). MATERIALS AND METHODS: Mammograms of 41 postmenopausal women obtained before and 1 year after the initiation of HRT were evaluated blindly according to the quantitative density percentage method and the Wolfe classification system. RESULTS: Mammographic densities increased compared with baseline values in 73% of subjects (mean increase, 6.7%; 95% confidence interval, 2.5%, 11.0%; P = .003). A shift in Wolfe classification from lower to greater parenchymal density was noted in 24% of subjects (P = .016). Multivariate analysis results indicated that the lower the tissue density percentage before treatment, the greater the increase in density percentage after treatment. CONCLUSION: An increase in mammographic density was demonstrated in most subjects undergoing continuous combined HRT and was most pronounced in subjects with a lower baseline density percentage.

Original languageEnglish
Pages (from-to)433-437
Number of pages5
JournalRadiology
Volume196
Issue number2
StatePublished - Aug 1995

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Therapeutics
Multivariate Analysis
Breast Density
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology

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Laya, M. B., Gallagher, J. C. G., Schreiman, J. S., Larson, E. B., Watson, P., & Weinstein, L. (1995). Effect of postmenopausal hormonal replacement therapy on mammographic density and parenchymal pattern. Radiology, 196(2), 433-437.

Effect of postmenopausal hormonal replacement therapy on mammographic density and parenchymal pattern. / Laya, Mary B.; Gallagher, John Christopher G.; Schreiman, Judith S.; Larson, Eric B.; Watson, Patrice; Weinstein, Louis.

In: Radiology, Vol. 196, No. 2, 08.1995, p. 433-437.

Research output: Contribution to journalArticle

Laya, MB, Gallagher, JCG, Schreiman, JS, Larson, EB, Watson, P & Weinstein, L 1995, 'Effect of postmenopausal hormonal replacement therapy on mammographic density and parenchymal pattern', Radiology, vol. 196, no. 2, pp. 433-437.
Laya MB, Gallagher JCG, Schreiman JS, Larson EB, Watson P, Weinstein L. Effect of postmenopausal hormonal replacement therapy on mammographic density and parenchymal pattern. Radiology. 1995 Aug;196(2):433-437.
Laya, Mary B. ; Gallagher, John Christopher G. ; Schreiman, Judith S. ; Larson, Eric B. ; Watson, Patrice ; Weinstein, Louis. / Effect of postmenopausal hormonal replacement therapy on mammographic density and parenchymal pattern. In: Radiology. 1995 ; Vol. 196, No. 2. pp. 433-437.
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