Effect of prior bilateral oophorectomy on the presentation of breast cancer in BRCA1 and BRCA2 mutation carriers

Kelly A. Metcalfe, William D. Foulkes, Henry T. Lynch, Parviz Ghadirian, Nadine Tung, Ivo A. Olivotto, Ellen Warner, Olufunmilayo Olopade, Andrea Eisen, Barbara Weber, Jane McLennan, Ping Sun, Steven A. Narod

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Purpose: To compare the presentation of invasive breast cancer in BRCA1 and BRCA2 mutation carriers with and without prior bilateral oophorectomy. Patients and methods: Women with a BRCA1 or BRCA2 mutation with the diagnosis of invasive breast cancer were identified from ten cancer genetics clinics. The medical history, medical treatment records and pathology reports for the breast cancers were reviewed. Information was abstracted from medical charts, including history (and date) of oophorectomy, date of breast cancer diagnosis, stage of disease, and pathologic characteristics of the breast cancer. Women with prior bilateral oophorectomy were matched by age, year of diagnosis, and mutation with one or more women who had two intact ovaries at the time of breast cancer diagnosis. Characteristics of the breast tumours were compared between the two groups. Results: Women with prior bilateral oophorectomy presented with smaller tumours on average compared to women without prior oophorectomy (mean size 1.50 cm vs. 1.95 cm; p=0.01). Additionally, although not statistically significant, women with intact ovaries were more likely to have high-grade tumour (70% vs. 54%: p=0.10) and to have positive lymph nodes (34% vs. 18%; p=0.11) compared to women with prior bilateral oophorectomy. Conclusions: Bilateral oophorectomy prior to breast cancer appears to favourably influence the biological presentation of breast cancer in BRCA1 and BRCA2 mutation carriers.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalHereditary Cancer in Clinical Practice
Volume3
Issue number2
StatePublished - Jun 15 2005

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Ovariectomy
Breast Neoplasms
Mutation
Ovary
Neoplasms
Medical Records
Lymph Nodes
History
Pathology

All Science Journal Classification (ASJC) codes

  • Oncology
  • Genetics(clinical)
  • Cancer Research

Cite this

Metcalfe, K. A., Foulkes, W. D., Lynch, H. T., Ghadirian, P., Tung, N., Olivotto, I. A., ... Narod, S. A. (2005). Effect of prior bilateral oophorectomy on the presentation of breast cancer in BRCA1 and BRCA2 mutation carriers. Hereditary Cancer in Clinical Practice, 3(2), 53-57.

Effect of prior bilateral oophorectomy on the presentation of breast cancer in BRCA1 and BRCA2 mutation carriers. / Metcalfe, Kelly A.; Foulkes, William D.; Lynch, Henry T.; Ghadirian, Parviz; Tung, Nadine; Olivotto, Ivo A.; Warner, Ellen; Olopade, Olufunmilayo; Eisen, Andrea; Weber, Barbara; McLennan, Jane; Sun, Ping; Narod, Steven A.

In: Hereditary Cancer in Clinical Practice, Vol. 3, No. 2, 15.06.2005, p. 53-57.

Research output: Contribution to journalReview article

Metcalfe, KA, Foulkes, WD, Lynch, HT, Ghadirian, P, Tung, N, Olivotto, IA, Warner, E, Olopade, O, Eisen, A, Weber, B, McLennan, J, Sun, P & Narod, SA 2005, 'Effect of prior bilateral oophorectomy on the presentation of breast cancer in BRCA1 and BRCA2 mutation carriers', Hereditary Cancer in Clinical Practice, vol. 3, no. 2, pp. 53-57.
Metcalfe, Kelly A. ; Foulkes, William D. ; Lynch, Henry T. ; Ghadirian, Parviz ; Tung, Nadine ; Olivotto, Ivo A. ; Warner, Ellen ; Olopade, Olufunmilayo ; Eisen, Andrea ; Weber, Barbara ; McLennan, Jane ; Sun, Ping ; Narod, Steven A. / Effect of prior bilateral oophorectomy on the presentation of breast cancer in BRCA1 and BRCA2 mutation carriers. In: Hereditary Cancer in Clinical Practice. 2005 ; Vol. 3, No. 2. pp. 53-57.
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abstract = "Purpose: To compare the presentation of invasive breast cancer in BRCA1 and BRCA2 mutation carriers with and without prior bilateral oophorectomy. Patients and methods: Women with a BRCA1 or BRCA2 mutation with the diagnosis of invasive breast cancer were identified from ten cancer genetics clinics. The medical history, medical treatment records and pathology reports for the breast cancers were reviewed. Information was abstracted from medical charts, including history (and date) of oophorectomy, date of breast cancer diagnosis, stage of disease, and pathologic characteristics of the breast cancer. Women with prior bilateral oophorectomy were matched by age, year of diagnosis, and mutation with one or more women who had two intact ovaries at the time of breast cancer diagnosis. Characteristics of the breast tumours were compared between the two groups. Results: Women with prior bilateral oophorectomy presented with smaller tumours on average compared to women without prior oophorectomy (mean size 1.50 cm vs. 1.95 cm; p=0.01). Additionally, although not statistically significant, women with intact ovaries were more likely to have high-grade tumour (70{\%} vs. 54{\%}: p=0.10) and to have positive lymph nodes (34{\%} vs. 18{\%}; p=0.11) compared to women with prior bilateral oophorectomy. Conclusions: Bilateral oophorectomy prior to breast cancer appears to favourably influence the biological presentation of breast cancer in BRCA1 and BRCA2 mutation carriers.",
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AU - Metcalfe, Kelly A.

AU - Foulkes, William D.

AU - Lynch, Henry T.

AU - Ghadirian, Parviz

AU - Tung, Nadine

AU - Olivotto, Ivo A.

AU - Warner, Ellen

AU - Olopade, Olufunmilayo

AU - Eisen, Andrea

AU - Weber, Barbara

AU - McLennan, Jane

AU - Sun, Ping

AU - Narod, Steven A.

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N2 - Purpose: To compare the presentation of invasive breast cancer in BRCA1 and BRCA2 mutation carriers with and without prior bilateral oophorectomy. Patients and methods: Women with a BRCA1 or BRCA2 mutation with the diagnosis of invasive breast cancer were identified from ten cancer genetics clinics. The medical history, medical treatment records and pathology reports for the breast cancers were reviewed. Information was abstracted from medical charts, including history (and date) of oophorectomy, date of breast cancer diagnosis, stage of disease, and pathologic characteristics of the breast cancer. Women with prior bilateral oophorectomy were matched by age, year of diagnosis, and mutation with one or more women who had two intact ovaries at the time of breast cancer diagnosis. Characteristics of the breast tumours were compared between the two groups. Results: Women with prior bilateral oophorectomy presented with smaller tumours on average compared to women without prior oophorectomy (mean size 1.50 cm vs. 1.95 cm; p=0.01). Additionally, although not statistically significant, women with intact ovaries were more likely to have high-grade tumour (70% vs. 54%: p=0.10) and to have positive lymph nodes (34% vs. 18%; p=0.11) compared to women with prior bilateral oophorectomy. Conclusions: Bilateral oophorectomy prior to breast cancer appears to favourably influence the biological presentation of breast cancer in BRCA1 and BRCA2 mutation carriers.

AB - Purpose: To compare the presentation of invasive breast cancer in BRCA1 and BRCA2 mutation carriers with and without prior bilateral oophorectomy. Patients and methods: Women with a BRCA1 or BRCA2 mutation with the diagnosis of invasive breast cancer were identified from ten cancer genetics clinics. The medical history, medical treatment records and pathology reports for the breast cancers were reviewed. Information was abstracted from medical charts, including history (and date) of oophorectomy, date of breast cancer diagnosis, stage of disease, and pathologic characteristics of the breast cancer. Women with prior bilateral oophorectomy were matched by age, year of diagnosis, and mutation with one or more women who had two intact ovaries at the time of breast cancer diagnosis. Characteristics of the breast tumours were compared between the two groups. Results: Women with prior bilateral oophorectomy presented with smaller tumours on average compared to women without prior oophorectomy (mean size 1.50 cm vs. 1.95 cm; p=0.01). Additionally, although not statistically significant, women with intact ovaries were more likely to have high-grade tumour (70% vs. 54%: p=0.10) and to have positive lymph nodes (34% vs. 18%; p=0.11) compared to women with prior bilateral oophorectomy. Conclusions: Bilateral oophorectomy prior to breast cancer appears to favourably influence the biological presentation of breast cancer in BRCA1 and BRCA2 mutation carriers.

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