Effect of recombinant human bone morphogenetic protein-2 on bone regeneration and osseointegration of dental implants

Nikitas Sykaras, Robert G. Triplett, Martha E. Nunn, Anthony M. Iacopino, Lynne A. Opperman

Research output: Contribution to journalArticle

52 Scopus citations


Recombinant human bone morphogenetic protein-2 (rhBMP-2) induced bone regeneration and osseointegration was evaluated in bony defects created within the hollow chamber of endosseous dental implants in 14 foxhound dogs. Bilateral extractions of mandibular premolars were performed and surgical implantation of 104 hollow cylinder implants followed after 8 weeks of healing. Experimental implants had their hollow chamber filled with 20 μg of rhBMP-2 delivered with a bovine collagen carrier, whereas the control implants had their apical chamber left empty. Dogs were followed for 2, 4, 8 and 12 weeks. Histomorphometric evaluation and immunohistochemical analysis were performed. Minimal bone was regenerated at 2 weeks for both groups. At 4 weeks, bone fill averaged 23.48% for the rhBMP-2 and 5.98% for the control group (P0.05). Bone-implant contact (BIC) increased for both groups over time and at 8 weeks the rhBMP-2 BIC value was 18.65% and for the control 7.22% (P

Original languageEnglish
Pages (from-to)339-349
Number of pages11
JournalClinical Oral Implants Research
Issue number4
Publication statusPublished - 2001
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Dentistry(all)

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