Effect of seven fluoroquinolones on the determination of serum creatinine by the picric acid and enzymatic methods

Firouzan Massoomi, Herbert G. Mathews, Christopher J. Destache

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Abstract

To investigate in vitro the interaction of seven fluoroquinolone antibiotics with the determination of serum creatinine by the picric acid and enzymatic methods. This blind, in vitro study assayed duplicate serum samples for creatinine by the picric acid and enzymatic methods with averaged spiked concentrations of 2.71, 13.56, 27.12, and 108.47 μmol/L of ciprofloxacin, fleroxacin, lomefloxacin, ofloxacin, 1-ofloxacin, sparfloxacin, and temafloxacin. Cefoxitin (in concentrations of 233.9, 1169.6, 1754.4, and 2339.2 μmol/L) was used as a positive control for the picric acid assay. University-affiliated hospital, Department of Pharmaceutical Services and Clinical Chemistry section of the Department of Pathology. The serum creatinine samples spiked with the seven substituted fluoroquinolones and cefoxitin were assayed by both the picric acid and enzymatic assays. Statistical analysis compared the spiked samples with blank serum by Student's t-test and concentration ranges were compared by analysis of variance. A statistically significant interference with serum creatinine was p

Original languageEnglish
Pages (from-to)586-588
Number of pages3
JournalAnnals of Pharmacotherapy
Volume27
Issue number5
DOIs
StatePublished - 1993

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Fluoroquinolones
Creatinine
Cefoxitin
Serum
Ofloxacin
temafloxacin
Fleroxacin
Hospital Pharmacy Services
Clinical Chemistry
Pharmaceutical Chemistry
Hospital Departments
Enzyme Assays
Ciprofloxacin
Analysis of Variance
picric acid
Pathology
Students
Anti-Bacterial Agents
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Effect of seven fluoroquinolones on the determination of serum creatinine by the picric acid and enzymatic methods. / Massoomi, Firouzan; Mathews, Herbert G.; Destache, Christopher J.

In: Annals of Pharmacotherapy, Vol. 27, No. 5, 1993, p. 586-588.

Research output: Contribution to journalComment/debate

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