Effect of smoking on breast cancer in carriers of mutant BRCA1 or BRCA2 genes

Jean Sébastien Brunet, Parviz Ghadirian, Timothy R. Rebbeck, Caryn Lerman, Judy E. Garber, Patricia N. Tonin, John Abrahamson, William D. Foulkes, Mary Daly, Josephine Wagner-Costalas, Andrew Godwin, Olufunmilayo I. Olopade, Roxana Moslehi, Alexander Liede, P. Andrew Futreal, Barbara L. Weber, Gilbert M. Lenoir, Henry T. Lynch, Steven A. Narod

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Abstract

Background: Smoking has carcinogenic effects, and possibly antiestrogenic effects as well, but it has not been found to be risk factor for breast cancer in women in the general population. However, hereditary breast cancer is primarily a disease of premenopausal women, and interactions between genes and hormonal and environmental risk factors may be particularly important in this subgroup. Methods: We conducted a matched case-control study of breast cabncer among women who have been identified to be carriers of a deleterious mutation in either the BRCA1 or the BRCA2 gene. These women were assessed for genetic risk at one of several genetic counseling programs for cancer in North America. Information about lifetime smoking history was derived from a questionnaire routinely administered to women who were found to carry a mutation in either gene. Smoking histories of case subjects with breast cancer and age-matched healthy control subjects were compared. Odds ratios for developing breast cancer were determined for smokers versus nonsmokers by use of conditional logistic regression for matched sets after adjustment for other known risk factors. Results: Subjects with BRCA1 or BRCA2 gene mutations and breast cancer were significantly more likely to have been non-smokers than were subjects with mutations and without breast cancer (two-sided P = .007). In a multivariate analysis, subjects with BRCA1 or BRCA2 mutations who had smoked cigarettes for more than 4 pack-years (i.e., number of packs per day multiplied by the number of years of smoking) were found to have a lower breast cancer risk (odds ratio = 0.46, 95% confidence interval = 0.27-0.80; two-sided P = .006) than subjects with mutations who never smoked. Conclusions: This study raises the possibility that smoking reduces the risk of breast cancer in carriers of BRCA1 or BRCA2 gene mutations.

Original languageEnglish
Pages (from-to)761-766
Number of pages6
JournalJournal of the National Cancer Institute
Volume90
Issue number10
StatePublished - May 20 1998

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BRCA2 Gene
BRCA1 Gene
Smoking
Breast Neoplasms
Mutation
Odds Ratio
Genetic Counseling
North America
Tobacco Products
Genes
Case-Control Studies
Healthy Volunteers
Breast
Multivariate Analysis
Logistic Models
History
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Brunet, J. S., Ghadirian, P., Rebbeck, T. R., Lerman, C., Garber, J. E., Tonin, P. N., ... Narod, S. A. (1998). Effect of smoking on breast cancer in carriers of mutant BRCA1 or BRCA2 genes. Journal of the National Cancer Institute, 90(10), 761-766.

Effect of smoking on breast cancer in carriers of mutant BRCA1 or BRCA2 genes. / Brunet, Jean Sébastien; Ghadirian, Parviz; Rebbeck, Timothy R.; Lerman, Caryn; Garber, Judy E.; Tonin, Patricia N.; Abrahamson, John; Foulkes, William D.; Daly, Mary; Wagner-Costalas, Josephine; Godwin, Andrew; Olopade, Olufunmilayo I.; Moslehi, Roxana; Liede, Alexander; Futreal, P. Andrew; Weber, Barbara L.; Lenoir, Gilbert M.; Lynch, Henry T.; Narod, Steven A.

In: Journal of the National Cancer Institute, Vol. 90, No. 10, 20.05.1998, p. 761-766.

Research output: Contribution to journalArticle

Brunet, JS, Ghadirian, P, Rebbeck, TR, Lerman, C, Garber, JE, Tonin, PN, Abrahamson, J, Foulkes, WD, Daly, M, Wagner-Costalas, J, Godwin, A, Olopade, OI, Moslehi, R, Liede, A, Futreal, PA, Weber, BL, Lenoir, GM, Lynch, HT & Narod, SA 1998, 'Effect of smoking on breast cancer in carriers of mutant BRCA1 or BRCA2 genes', Journal of the National Cancer Institute, vol. 90, no. 10, pp. 761-766.
Brunet JS, Ghadirian P, Rebbeck TR, Lerman C, Garber JE, Tonin PN et al. Effect of smoking on breast cancer in carriers of mutant BRCA1 or BRCA2 genes. Journal of the National Cancer Institute. 1998 May 20;90(10):761-766.
Brunet, Jean Sébastien ; Ghadirian, Parviz ; Rebbeck, Timothy R. ; Lerman, Caryn ; Garber, Judy E. ; Tonin, Patricia N. ; Abrahamson, John ; Foulkes, William D. ; Daly, Mary ; Wagner-Costalas, Josephine ; Godwin, Andrew ; Olopade, Olufunmilayo I. ; Moslehi, Roxana ; Liede, Alexander ; Futreal, P. Andrew ; Weber, Barbara L. ; Lenoir, Gilbert M. ; Lynch, Henry T. ; Narod, Steven A. / Effect of smoking on breast cancer in carriers of mutant BRCA1 or BRCA2 genes. In: Journal of the National Cancer Institute. 1998 ; Vol. 90, No. 10. pp. 761-766.
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abstract = "Background: Smoking has carcinogenic effects, and possibly antiestrogenic effects as well, but it has not been found to be risk factor for breast cancer in women in the general population. However, hereditary breast cancer is primarily a disease of premenopausal women, and interactions between genes and hormonal and environmental risk factors may be particularly important in this subgroup. Methods: We conducted a matched case-control study of breast cabncer among women who have been identified to be carriers of a deleterious mutation in either the BRCA1 or the BRCA2 gene. These women were assessed for genetic risk at one of several genetic counseling programs for cancer in North America. Information about lifetime smoking history was derived from a questionnaire routinely administered to women who were found to carry a mutation in either gene. Smoking histories of case subjects with breast cancer and age-matched healthy control subjects were compared. Odds ratios for developing breast cancer were determined for smokers versus nonsmokers by use of conditional logistic regression for matched sets after adjustment for other known risk factors. Results: Subjects with BRCA1 or BRCA2 gene mutations and breast cancer were significantly more likely to have been non-smokers than were subjects with mutations and without breast cancer (two-sided P = .007). In a multivariate analysis, subjects with BRCA1 or BRCA2 mutations who had smoked cigarettes for more than 4 pack-years (i.e., number of packs per day multiplied by the number of years of smoking) were found to have a lower breast cancer risk (odds ratio = 0.46, 95{\%} confidence interval = 0.27-0.80; two-sided P = .006) than subjects with mutations who never smoked. Conclusions: This study raises the possibility that smoking reduces the risk of breast cancer in carriers of BRCA1 or BRCA2 gene mutations.",
author = "Brunet, {Jean S{\'e}bastien} and Parviz Ghadirian and Rebbeck, {Timothy R.} and Caryn Lerman and Garber, {Judy E.} and Tonin, {Patricia N.} and John Abrahamson and Foulkes, {William D.} and Mary Daly and Josephine Wagner-Costalas and Andrew Godwin and Olopade, {Olufunmilayo I.} and Roxana Moslehi and Alexander Liede and Futreal, {P. Andrew} and Weber, {Barbara L.} and Lenoir, {Gilbert M.} and Lynch, {Henry T.} and Narod, {Steven A.}",
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T1 - Effect of smoking on breast cancer in carriers of mutant BRCA1 or BRCA2 genes

AU - Brunet, Jean Sébastien

AU - Ghadirian, Parviz

AU - Rebbeck, Timothy R.

AU - Lerman, Caryn

AU - Garber, Judy E.

AU - Tonin, Patricia N.

AU - Abrahamson, John

AU - Foulkes, William D.

AU - Daly, Mary

AU - Wagner-Costalas, Josephine

AU - Godwin, Andrew

AU - Olopade, Olufunmilayo I.

AU - Moslehi, Roxana

AU - Liede, Alexander

AU - Futreal, P. Andrew

AU - Weber, Barbara L.

AU - Lenoir, Gilbert M.

AU - Lynch, Henry T.

AU - Narod, Steven A.

PY - 1998/5/20

Y1 - 1998/5/20

N2 - Background: Smoking has carcinogenic effects, and possibly antiestrogenic effects as well, but it has not been found to be risk factor for breast cancer in women in the general population. However, hereditary breast cancer is primarily a disease of premenopausal women, and interactions between genes and hormonal and environmental risk factors may be particularly important in this subgroup. Methods: We conducted a matched case-control study of breast cabncer among women who have been identified to be carriers of a deleterious mutation in either the BRCA1 or the BRCA2 gene. These women were assessed for genetic risk at one of several genetic counseling programs for cancer in North America. Information about lifetime smoking history was derived from a questionnaire routinely administered to women who were found to carry a mutation in either gene. Smoking histories of case subjects with breast cancer and age-matched healthy control subjects were compared. Odds ratios for developing breast cancer were determined for smokers versus nonsmokers by use of conditional logistic regression for matched sets after adjustment for other known risk factors. Results: Subjects with BRCA1 or BRCA2 gene mutations and breast cancer were significantly more likely to have been non-smokers than were subjects with mutations and without breast cancer (two-sided P = .007). In a multivariate analysis, subjects with BRCA1 or BRCA2 mutations who had smoked cigarettes for more than 4 pack-years (i.e., number of packs per day multiplied by the number of years of smoking) were found to have a lower breast cancer risk (odds ratio = 0.46, 95% confidence interval = 0.27-0.80; two-sided P = .006) than subjects with mutations who never smoked. Conclusions: This study raises the possibility that smoking reduces the risk of breast cancer in carriers of BRCA1 or BRCA2 gene mutations.

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