TY - JOUR
T1 - Effect of smoking on breast cancer in carriers of mutant BRCA1 or BRCA2 genes
AU - Brunet, Jean Sébastien
AU - Ghadirian, Parviz
AU - Rebbeck, Timothy R.
AU - Lerman, Caryn
AU - Garber, Judy E.
AU - Tonin, Patricia N.
AU - Abrahamson, John
AU - Foulkes, William D.
AU - Daly, Mary
AU - Wagner-Costalas, Josephine
AU - Godwin, Andrew
AU - Olopade, Olufunmilayo I.
AU - Moslehi, Roxana
AU - Liede, Alexander
AU - Futreal, P. Andrew
AU - Weber, Barbara L.
AU - Lenoir, Gilbert M.
AU - Lynch, Henry T.
AU - Narod, Steven A.
PY - 1998/5/20
Y1 - 1998/5/20
N2 - Background: Smoking has carcinogenic effects, and possibly antiestrogenic effects as well, but it has not been found to be risk factor for breast cancer in women in the general population. However, hereditary breast cancer is primarily a disease of premenopausal women, and interactions between genes and hormonal and environmental risk factors may be particularly important in this subgroup. Methods: We conducted a matched case-control study of breast cabncer among women who have been identified to be carriers of a deleterious mutation in either the BRCA1 or the BRCA2 gene. These women were assessed for genetic risk at one of several genetic counseling programs for cancer in North America. Information about lifetime smoking history was derived from a questionnaire routinely administered to women who were found to carry a mutation in either gene. Smoking histories of case subjects with breast cancer and age-matched healthy control subjects were compared. Odds ratios for developing breast cancer were determined for smokers versus nonsmokers by use of conditional logistic regression for matched sets after adjustment for other known risk factors. Results: Subjects with BRCA1 or BRCA2 gene mutations and breast cancer were significantly more likely to have been non-smokers than were subjects with mutations and without breast cancer (two-sided P = .007). In a multivariate analysis, subjects with BRCA1 or BRCA2 mutations who had smoked cigarettes for more than 4 pack-years (i.e., number of packs per day multiplied by the number of years of smoking) were found to have a lower breast cancer risk (odds ratio = 0.46, 95% confidence interval = 0.27-0.80; two-sided P = .006) than subjects with mutations who never smoked. Conclusions: This study raises the possibility that smoking reduces the risk of breast cancer in carriers of BRCA1 or BRCA2 gene mutations.
AB - Background: Smoking has carcinogenic effects, and possibly antiestrogenic effects as well, but it has not been found to be risk factor for breast cancer in women in the general population. However, hereditary breast cancer is primarily a disease of premenopausal women, and interactions between genes and hormonal and environmental risk factors may be particularly important in this subgroup. Methods: We conducted a matched case-control study of breast cabncer among women who have been identified to be carriers of a deleterious mutation in either the BRCA1 or the BRCA2 gene. These women were assessed for genetic risk at one of several genetic counseling programs for cancer in North America. Information about lifetime smoking history was derived from a questionnaire routinely administered to women who were found to carry a mutation in either gene. Smoking histories of case subjects with breast cancer and age-matched healthy control subjects were compared. Odds ratios for developing breast cancer were determined for smokers versus nonsmokers by use of conditional logistic regression for matched sets after adjustment for other known risk factors. Results: Subjects with BRCA1 or BRCA2 gene mutations and breast cancer were significantly more likely to have been non-smokers than were subjects with mutations and without breast cancer (two-sided P = .007). In a multivariate analysis, subjects with BRCA1 or BRCA2 mutations who had smoked cigarettes for more than 4 pack-years (i.e., number of packs per day multiplied by the number of years of smoking) were found to have a lower breast cancer risk (odds ratio = 0.46, 95% confidence interval = 0.27-0.80; two-sided P = .006) than subjects with mutations who never smoked. Conclusions: This study raises the possibility that smoking reduces the risk of breast cancer in carriers of BRCA1 or BRCA2 gene mutations.
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U2 - 10.1093/jnci/90.10.761
DO - 10.1093/jnci/90.10.761
M3 - Article
C2 - 9605646
AN - SCOPUS:0032550761
VL - 90
SP - 761
EP - 766
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 10
ER -