Effect of terfenadine on cold air-induced bronchospasm

Againdra K. Bewtra, R. J. Hopp, N. M. Nair, R. G. Townley

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Cold air hyperventilation challenge (CAHC) has been shown to induce bronchoconstriction in asthmatics. We investigated whether terfenadine, a non-sedating H1 antihistamine, had a protective effect against CAHC. Twelve mild-moderate asthmatics, sensitive to both methacholine and CAHC, underwent a double-blind 3-way crossover study of terfenadine at doses of 0, 120, and 240 mg. For four hours after administration of the study drug, pulmonary responses were measured, followed by a CAHC. There was a significant improvement in pulmonary function on the 120-mg and 240-mg days. The percent drop in FEV1 to CAHC was determined by comparing the pre-challenge baseline to the challenge responses. There was a significant attenuation in the FEV1 fall immediately after challenge on active drug days, but it was not sustained. Terfenadine appears to have an attenuating effect against CAHC-induced bronchoconstriction.

Original languageEnglish
Pages (from-to)299-301
Number of pages3
JournalAnnals of Allergy
Volume62
Issue number4
StatePublished - 1989

Fingerprint

Terfenadine
Bronchial Spasm
Hyperventilation
Air
Bronchoconstriction
Non-Sedating Histamine H1 Antagonists
Lung
Methacholine Chloride
Pharmaceutical Preparations
Cross-Over Studies

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

Cite this

Bewtra, A. K., Hopp, R. J., Nair, N. M., & Townley, R. G. (1989). Effect of terfenadine on cold air-induced bronchospasm. Annals of Allergy, 62(4), 299-301.

Effect of terfenadine on cold air-induced bronchospasm. / Bewtra, Againdra K.; Hopp, R. J.; Nair, N. M.; Townley, R. G.

In: Annals of Allergy, Vol. 62, No. 4, 1989, p. 299-301.

Research output: Contribution to journalArticle

Bewtra, AK, Hopp, RJ, Nair, NM & Townley, RG 1989, 'Effect of terfenadine on cold air-induced bronchospasm', Annals of Allergy, vol. 62, no. 4, pp. 299-301.
Bewtra AK, Hopp RJ, Nair NM, Townley RG. Effect of terfenadine on cold air-induced bronchospasm. Annals of Allergy. 1989;62(4):299-301.
Bewtra, Againdra K. ; Hopp, R. J. ; Nair, N. M. ; Townley, R. G. / Effect of terfenadine on cold air-induced bronchospasm. In: Annals of Allergy. 1989 ; Vol. 62, No. 4. pp. 299-301.
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