Effect of terfenadine on neutrophil and eosinophil chemotactic activities after inhalation of platelet-activating factor in vivo and on neutrophil chemotaxis in vitro

Chiharu Okada, Russell J. Hopp, Hidefumi Miyagawa, Haruhito Sugiyama, Nicki M. Nair, Againdra K. Bewtra, Robert G. Townley

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In this double-blind crossover study we evaluated the effect of terfenadine on the rise in neutrophil chemotactic activity (NCA) and eosinophil chemotactic activity (ECA) in serum induced by platelet-activating factor (PAF) inhalation in 8 asthmatics. Additionally, we examined the direct effect of terfenadine on neutrophil chemotaxis in vitro in 7 allergic subjects. NCA and ECA in serum after PAF inhalation and neutrophil chemotaxis were measured using a modified Boyden chamber method. An initial elevation of NCA after PAF inhalation was inhibited by terfenadine, but the effect was diminished after subsequent PAF inhalations. Terfenadine showed no effect on ECA. In vitro PAF- and fMLP-induced neutrophil chemotaxis were significantly inhibited by terfenadine. These results suggest that terfenadine may have antiallergic properties in addition to its H1 receptor blockade.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume97
Issue number3
DOIs
StatePublished - 1992

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Terfenadine
Platelet Activating Factor
Chemotaxis
Eosinophils
Inhalation
Neutrophils
Histamine H1 Receptors
Anti-Allergic Agents
Serum
Double-Blind Method
Cross-Over Studies
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy

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Effect of terfenadine on neutrophil and eosinophil chemotactic activities after inhalation of platelet-activating factor in vivo and on neutrophil chemotaxis in vitro. / Okada, Chiharu; Hopp, Russell J.; Miyagawa, Hidefumi; Sugiyama, Haruhito; Nair, Nicki M.; Bewtra, Againdra K.; Townley, Robert G.

In: International Archives of Allergy and Immunology, Vol. 97, No. 3, 1992, p. 181-186.

Research output: Contribution to journalArticle

Okada, Chiharu ; Hopp, Russell J. ; Miyagawa, Hidefumi ; Sugiyama, Haruhito ; Nair, Nicki M. ; Bewtra, Againdra K. ; Townley, Robert G. / Effect of terfenadine on neutrophil and eosinophil chemotactic activities after inhalation of platelet-activating factor in vivo and on neutrophil chemotaxis in vitro. In: International Archives of Allergy and Immunology. 1992 ; Vol. 97, No. 3. pp. 181-186.
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abstract = "In this double-blind crossover study we evaluated the effect of terfenadine on the rise in neutrophil chemotactic activity (NCA) and eosinophil chemotactic activity (ECA) in serum induced by platelet-activating factor (PAF) inhalation in 8 asthmatics. Additionally, we examined the direct effect of terfenadine on neutrophil chemotaxis in vitro in 7 allergic subjects. NCA and ECA in serum after PAF inhalation and neutrophil chemotaxis were measured using a modified Boyden chamber method. An initial elevation of NCA after PAF inhalation was inhibited by terfenadine, but the effect was diminished after subsequent PAF inhalations. Terfenadine showed no effect on ECA. In vitro PAF- and fMLP-induced neutrophil chemotaxis were significantly inhibited by terfenadine. These results suggest that terfenadine may have antiallergic properties in addition to its H1 receptor blockade.",
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AU - Nair, Nicki M.

AU - Bewtra, Againdra K.

AU - Townley, Robert G.

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AB - In this double-blind crossover study we evaluated the effect of terfenadine on the rise in neutrophil chemotactic activity (NCA) and eosinophil chemotactic activity (ECA) in serum induced by platelet-activating factor (PAF) inhalation in 8 asthmatics. Additionally, we examined the direct effect of terfenadine on neutrophil chemotaxis in vitro in 7 allergic subjects. NCA and ECA in serum after PAF inhalation and neutrophil chemotaxis were measured using a modified Boyden chamber method. An initial elevation of NCA after PAF inhalation was inhibited by terfenadine, but the effect was diminished after subsequent PAF inhalations. Terfenadine showed no effect on ECA. In vitro PAF- and fMLP-induced neutrophil chemotaxis were significantly inhibited by terfenadine. These results suggest that terfenadine may have antiallergic properties in addition to its H1 receptor blockade.

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