Effect of terfenadine on the bronchoconstriction induced by ultrasonically nebulized distilled water

R. J. Hopp, Againdra K. Bewtra, N. M. Nair, R. G. Townley

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Abstract

Ultrasonically nebulized distilled water (UNDW) has been shown to induce bronchoconstriction in asthmatics. The proposed mechanism is through changes in osmolarity of the airway fluids and subsequent release of mediators from airway mast cells. We investigated whether terfenadine has a protective effect on UNDW challenges. Twelve mild-to-moderate asthmatics responded to screening a metacholine and UNDW challenge. For four hours after the ingestion of 0, 120, and 240 mg of terfenadine pulmonary responses were performed, followed by a UNDW challenge. Nine of 12 subjects dropped 20% after 120 mg and after 240 mg. There was a suggestion of a protective effect at 120 mg (P = .054), which was significant at 240 mg (P = .012) when the areas under the dose-response curves were compared. Bronchoconstriction induced by UNDW may in part be caused by histamine release and was attenuated by an oral antihistamine.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalAnnals of Allergy
Volume61
Issue number1
Publication statusPublished - 1988

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

Cite this

Hopp, R. J., Bewtra, A. K., Nair, N. M., & Townley, R. G. (1988). Effect of terfenadine on the bronchoconstriction induced by ultrasonically nebulized distilled water. Annals of Allergy, 61(1), 13-16.