Abstract
To define the potency order of the leukotrienes for inhibition of [3H] leukotriene D4 and [3H]leukotriene C4 binding, we investigated leukotriene C4, D4 and E4 competition with and without the serine-borate complex in guinea pig lung and brain homogenates. Without it, the rank order of their potency for inhibition of lung [3H]leukotriene D4 or [3H]leukotriene C4 binding was leukotriene C4 = leukotriene D4 > leukotriene E4. Presence of the complex altered the potency order for both competition studies: for the [3H]leukotriene D4 competition it was leukotriene D4 > leukotriene E4 = leukotriene C4 and for the [3H]leukotriene C4 competition it was leukotriene C4 ≫ leukotriene D4 ≥ leukotriene E4.
| Original language | English |
|---|---|
| Pages (from-to) | 612-617 |
| Number of pages | 6 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 119 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 15 1984 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Effect of the serine-borate complex on the relative ability of leukotriene C4, D4 and E4 to inhibit lung and brain [3H]leukotriene D4 and [3H]leukotriene C4 binding : Demonstration of the agonists' potency order for leukotriene D4 and leukotriene C4 receptors. / Cheng, John B.; Townley, Robert G.
In: Biochemical and Biophysical Research Communications, Vol. 119, No. 2, 15.03.1984, p. 612-617.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Effect of the serine-borate complex on the relative ability of leukotriene C4, D4 and E4 to inhibit lung and brain [3H]leukotriene D4 and [3H]leukotriene C4 binding
T2 - Demonstration of the agonists' potency order for leukotriene D4 and leukotriene C4 receptors
AU - Cheng, John B.
AU - Townley, Robert G.
PY - 1984/3/15
Y1 - 1984/3/15
N2 - To define the potency order of the leukotrienes for inhibition of [3H] leukotriene D4 and [3H]leukotriene C4 binding, we investigated leukotriene C4, D4 and E4 competition with and without the serine-borate complex in guinea pig lung and brain homogenates. Without it, the rank order of their potency for inhibition of lung [3H]leukotriene D4 or [3H]leukotriene C4 binding was leukotriene C4 = leukotriene D4 > leukotriene E4. Presence of the complex altered the potency order for both competition studies: for the [3H]leukotriene D4 competition it was leukotriene D4 > leukotriene E4 = leukotriene C4 and for the [3H]leukotriene C4 competition it was leukotriene C4 ≫ leukotriene D4 ≥ leukotriene E4.
AB - To define the potency order of the leukotrienes for inhibition of [3H] leukotriene D4 and [3H]leukotriene C4 binding, we investigated leukotriene C4, D4 and E4 competition with and without the serine-borate complex in guinea pig lung and brain homogenates. Without it, the rank order of their potency for inhibition of lung [3H]leukotriene D4 or [3H]leukotriene C4 binding was leukotriene C4 = leukotriene D4 > leukotriene E4. Presence of the complex altered the potency order for both competition studies: for the [3H]leukotriene D4 competition it was leukotriene D4 > leukotriene E4 = leukotriene C4 and for the [3H]leukotriene C4 competition it was leukotriene C4 ≫ leukotriene D4 ≥ leukotriene E4.
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U2 - 10.1016/S0006-291X(84)80293-4
DO - 10.1016/S0006-291X(84)80293-4
M3 - Article
VL - 119
SP - 612
EP - 617
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -