Effect of the serine-borate complex on the relative ability of leukotriene C4, D4 and E4 to inhibit lung and brain [3H]leukotriene D4 and [3H]leukotriene C4 binding

Demonstration of the agonists' potency order for leukotriene D4 and leukotriene C4 receptors

John B. Cheng, Robert G. Townley

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To define the potency order of the leukotrienes for inhibition of [3H] leukotriene D4 and [3H]leukotriene C4 binding, we investigated leukotriene C4, D4 and E4 competition with and without the serine-borate complex in guinea pig lung and brain homogenates. Without it, the rank order of their potency for inhibition of lung [3H]leukotriene D4 or [3H]leukotriene C4 binding was leukotriene C4 = leukotriene D4 > leukotriene E4. Presence of the complex altered the potency order for both competition studies: for the [3H]leukotriene D4 competition it was leukotriene D4 > leukotriene E4 = leukotriene C4 and for the [3H]leukotriene C4 competition it was leukotriene C4 ≫ leukotriene D4 ≥ leukotriene E4.

Original languageEnglish
Pages (from-to)612-617
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume119
Issue number2
DOIs
StatePublished - Mar 15 1984

Fingerprint

Leukotriene E4
Leukotriene D4
Leukotriene C4
Brain
Demonstrations
Lung
Leukotrienes
serine-borate complex
leukotriene C4 receptor
Guinea Pigs

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

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title = "Effect of the serine-borate complex on the relative ability of leukotriene C4, D4 and E4 to inhibit lung and brain [3H]leukotriene D4 and [3H]leukotriene C4 binding: Demonstration of the agonists' potency order for leukotriene D4 and leukotriene C4 receptors",
abstract = "To define the potency order of the leukotrienes for inhibition of [3H] leukotriene D4 and [3H]leukotriene C4 binding, we investigated leukotriene C4, D4 and E4 competition with and without the serine-borate complex in guinea pig lung and brain homogenates. Without it, the rank order of their potency for inhibition of lung [3H]leukotriene D4 or [3H]leukotriene C4 binding was leukotriene C4 = leukotriene D4 > leukotriene E4. Presence of the complex altered the potency order for both competition studies: for the [3H]leukotriene D4 competition it was leukotriene D4 > leukotriene E4 = leukotriene C4 and for the [3H]leukotriene C4 competition it was leukotriene C4 ≫ leukotriene D4 ≥ leukotriene E4.",
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AB - To define the potency order of the leukotrienes for inhibition of [3H] leukotriene D4 and [3H]leukotriene C4 binding, we investigated leukotriene C4, D4 and E4 competition with and without the serine-borate complex in guinea pig lung and brain homogenates. Without it, the rank order of their potency for inhibition of lung [3H]leukotriene D4 or [3H]leukotriene C4 binding was leukotriene C4 = leukotriene D4 > leukotriene E4. Presence of the complex altered the potency order for both competition studies: for the [3H]leukotriene D4 competition it was leukotriene D4 > leukotriene E4 = leukotriene C4 and for the [3H]leukotriene C4 competition it was leukotriene C4 ≫ leukotriene D4 ≥ leukotriene E4.

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