Effect of Vitamin D supplement use on serum concentrations of total 25OHD levels in elderly women

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Abstract

Vitamin D2 and D3 are generally considered equipotent in humans. As Vitamin D2 supplements are commonly used by elderly in United States, we determined the contribution of 25OHD2 to the total serum 25OHD levels by HPLC in elderly women who reported taking Vitamin D 2 supplements (n=56) and also in a group of randomly selected unsupplemented women (n=60). In addition, we compared the total serum 25OHD measured by HPLC with competitive protein-binding assay (CPBA), a method routinely employed to measure Vitamin D status. A correlation of 0.91 (P2 supplemented group was significantly higher than in unsupplemented group measured by HPLC (32 versus 28 ng/ml) and marginally higher measured by CPBA (33 vs. 31 ng/ml). Seventy eight percent of women taking Vitamin D2 supplements had appreciable amounts of circulating 25OHD2, which constituted about 25 percent of their total serum 25OHD. It is also interesting to note that Vitamin D deficiency was less prevalent in elderly women taking Vitamin D2 supplements (1.8%) compared to women not taking any supplements (12%).

Original languageEnglish
Pages (from-to)601-604
Number of pages4
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume89-90
DOIs
StatePublished - May 2004

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Ergocalciferols
Vitamin D
Serum
Competitive Binding
High Pressure Liquid Chromatography
Protein Binding
Assays
Vitamin D Deficiency
Cholecalciferol

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology

Cite this

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title = "Effect of Vitamin D supplement use on serum concentrations of total 25OHD levels in elderly women",
abstract = "Vitamin D2 and D3 are generally considered equipotent in humans. As Vitamin D2 supplements are commonly used by elderly in United States, we determined the contribution of 25OHD2 to the total serum 25OHD levels by HPLC in elderly women who reported taking Vitamin D 2 supplements (n=56) and also in a group of randomly selected unsupplemented women (n=60). In addition, we compared the total serum 25OHD measured by HPLC with competitive protein-binding assay (CPBA), a method routinely employed to measure Vitamin D status. A correlation of 0.91 (P2 supplemented group was significantly higher than in unsupplemented group measured by HPLC (32 versus 28 ng/ml) and marginally higher measured by CPBA (33 vs. 31 ng/ml). Seventy eight percent of women taking Vitamin D2 supplements had appreciable amounts of circulating 25OHD2, which constituted about 25 percent of their total serum 25OHD. It is also interesting to note that Vitamin D deficiency was less prevalent in elderly women taking Vitamin D2 supplements (1.8{\%}) compared to women not taking any supplements (12{\%}).",
author = "Rapuri, {P. B.} and Gallagher, {John Christopher G.}",
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T1 - Effect of Vitamin D supplement use on serum concentrations of total 25OHD levels in elderly women

AU - Rapuri, P. B.

AU - Gallagher, John Christopher G.

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N2 - Vitamin D2 and D3 are generally considered equipotent in humans. As Vitamin D2 supplements are commonly used by elderly in United States, we determined the contribution of 25OHD2 to the total serum 25OHD levels by HPLC in elderly women who reported taking Vitamin D 2 supplements (n=56) and also in a group of randomly selected unsupplemented women (n=60). In addition, we compared the total serum 25OHD measured by HPLC with competitive protein-binding assay (CPBA), a method routinely employed to measure Vitamin D status. A correlation of 0.91 (P2 supplemented group was significantly higher than in unsupplemented group measured by HPLC (32 versus 28 ng/ml) and marginally higher measured by CPBA (33 vs. 31 ng/ml). Seventy eight percent of women taking Vitamin D2 supplements had appreciable amounts of circulating 25OHD2, which constituted about 25 percent of their total serum 25OHD. It is also interesting to note that Vitamin D deficiency was less prevalent in elderly women taking Vitamin D2 supplements (1.8%) compared to women not taking any supplements (12%).

AB - Vitamin D2 and D3 are generally considered equipotent in humans. As Vitamin D2 supplements are commonly used by elderly in United States, we determined the contribution of 25OHD2 to the total serum 25OHD levels by HPLC in elderly women who reported taking Vitamin D 2 supplements (n=56) and also in a group of randomly selected unsupplemented women (n=60). In addition, we compared the total serum 25OHD measured by HPLC with competitive protein-binding assay (CPBA), a method routinely employed to measure Vitamin D status. A correlation of 0.91 (P2 supplemented group was significantly higher than in unsupplemented group measured by HPLC (32 versus 28 ng/ml) and marginally higher measured by CPBA (33 vs. 31 ng/ml). Seventy eight percent of women taking Vitamin D2 supplements had appreciable amounts of circulating 25OHD2, which constituted about 25 percent of their total serum 25OHD. It is also interesting to note that Vitamin D deficiency was less prevalent in elderly women taking Vitamin D2 supplements (1.8%) compared to women not taking any supplements (12%).

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