Abstract
Vitamin D2 and D3 are generally considered equipotent in humans. As Vitamin D2 supplements are commonly used by elderly in United States, we determined the contribution of 25OHD2 to the total serum 25OHD levels by HPLC in elderly women who reported taking Vitamin D 2 supplements (n=56) and also in a group of randomly selected unsupplemented women (n=60). In addition, we compared the total serum 25OHD measured by HPLC with competitive protein-binding assay (CPBA), a method routinely employed to measure Vitamin D status. A correlation of 0.91 (P2 supplemented group was significantly higher than in unsupplemented group measured by HPLC (32 versus 28 ng/ml) and marginally higher measured by CPBA (33 vs. 31 ng/ml). Seventy eight percent of women taking Vitamin D2 supplements had appreciable amounts of circulating 25OHD2, which constituted about 25 percent of their total serum 25OHD. It is also interesting to note that Vitamin D deficiency was less prevalent in elderly women taking Vitamin D2 supplements (1.8%) compared to women not taking any supplements (12%).
| Original language | English |
|---|---|
| Pages (from-to) | 601-604 |
| Number of pages | 4 |
| Journal | Journal of Steroid Biochemistry and Molecular Biology |
| Volume | 89-90 |
| DOIs | |
| State | Published - May 2004 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Endocrinology
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Effect of Vitamin D supplement use on serum concentrations of total 25OHD levels in elderly women. / Rapuri, P. B.; Gallagher, John Christopher G.
In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 89-90, 05.2004, p. 601-604.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of Vitamin D supplement use on serum concentrations of total 25OHD levels in elderly women
AU - Rapuri, P. B.
AU - Gallagher, John Christopher G.
PY - 2004/5
Y1 - 2004/5
N2 - Vitamin D2 and D3 are generally considered equipotent in humans. As Vitamin D2 supplements are commonly used by elderly in United States, we determined the contribution of 25OHD2 to the total serum 25OHD levels by HPLC in elderly women who reported taking Vitamin D 2 supplements (n=56) and also in a group of randomly selected unsupplemented women (n=60). In addition, we compared the total serum 25OHD measured by HPLC with competitive protein-binding assay (CPBA), a method routinely employed to measure Vitamin D status. A correlation of 0.91 (P2 supplemented group was significantly higher than in unsupplemented group measured by HPLC (32 versus 28 ng/ml) and marginally higher measured by CPBA (33 vs. 31 ng/ml). Seventy eight percent of women taking Vitamin D2 supplements had appreciable amounts of circulating 25OHD2, which constituted about 25 percent of their total serum 25OHD. It is also interesting to note that Vitamin D deficiency was less prevalent in elderly women taking Vitamin D2 supplements (1.8%) compared to women not taking any supplements (12%).
AB - Vitamin D2 and D3 are generally considered equipotent in humans. As Vitamin D2 supplements are commonly used by elderly in United States, we determined the contribution of 25OHD2 to the total serum 25OHD levels by HPLC in elderly women who reported taking Vitamin D 2 supplements (n=56) and also in a group of randomly selected unsupplemented women (n=60). In addition, we compared the total serum 25OHD measured by HPLC with competitive protein-binding assay (CPBA), a method routinely employed to measure Vitamin D status. A correlation of 0.91 (P2 supplemented group was significantly higher than in unsupplemented group measured by HPLC (32 versus 28 ng/ml) and marginally higher measured by CPBA (33 vs. 31 ng/ml). Seventy eight percent of women taking Vitamin D2 supplements had appreciable amounts of circulating 25OHD2, which constituted about 25 percent of their total serum 25OHD. It is also interesting to note that Vitamin D deficiency was less prevalent in elderly women taking Vitamin D2 supplements (1.8%) compared to women not taking any supplements (12%).
UR - http://www.scopus.com/inward/record.url?scp=3042594265&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3042594265&partnerID=8YFLogxK
U2 - 10.1016/j.jsbmb.2004.03.035
DO - 10.1016/j.jsbmb.2004.03.035
M3 - Article
C2 - 15225846
AN - SCOPUS:3042594265
VL - 89-90
SP - 601
EP - 604
JO - Journal of Steroid Biochemistry and Molecular Biology
JF - Journal of Steroid Biochemistry and Molecular Biology
SN - 0960-0760
ER -