Effects of chronic histamine and ovalbumin aerosols on pulmonary beta adrenergic receptors in sensitized guinea pigs

J. B. Cheng; R. G. Townley

Effects of chronic histamine and ovalbumin aerosols on pulmonary beta adrenergic receptors in sensitized guinea pigs

J. B. Cheng, R. G. Townley

Department of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Using (³H)dihydroalprenolol, we demonstrated that the concentration of pulmonary beta adrenergic receptor binding sites was lower in guinea pigs showing a marked bronchoconstrictive response to histamine and in ovalbumin-treated guinea pigs. This result suggests that the changed concentration of the pulmonary beta receptors in an animal model of asthma could result from bronchoconstriction stress.

Original language	English (US)
Pages (from-to)	507-510
Number of pages	4
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	36
Issue number	3
State	Published - Jan 1 1982

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Toxicology
Pharmacology
Pharmacology, Toxicology and Pharmaceutics(all)

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abstract = "Using (3H)dihydroalprenolol, we demonstrated that the concentration of pulmonary beta adrenergic receptor binding sites was lower in guinea pigs showing a marked bronchoconstrictive response to histamine and in ovalbumin-treated guinea pigs. This result suggests that the changed concentration of the pulmonary beta receptors in an animal model of asthma could result from bronchoconstriction stress.",

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AB - Using (3H)dihydroalprenolol, we demonstrated that the concentration of pulmonary beta adrenergic receptor binding sites was lower in guinea pigs showing a marked bronchoconstrictive response to histamine and in ovalbumin-treated guinea pigs. This result suggests that the changed concentration of the pulmonary beta receptors in an animal model of asthma could result from bronchoconstriction stress.

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