Effects of clindamycin on derepression of β-lactamases in Gram-negative bacteria

C. C. Sanders, W. E. Sanders, Richard V. Goering

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Derepression of β-lactamases in certain non-fastidious Gram-negative bacilli has been responsible for (i) the rapid development of resistance to a variety of β-lactam antibiotics and (ii) antagonism between β-lactam antibiotics. Therefore, the effects of a variety of inhibitiors of macromolecular synthesis on derepression of β-lactamase were investigated with four strains each of enterobacter and Pseudomonas aeruginosa. When tested at concentrations that were not inhibitory to growth, clindamycin was the most effect inhibitor of derepression of β-lactamases in some of the strains examined. In one enterobacter isolate, clindamycin completely prevented derepression of β-lactamases. This effect was highly specific as clindamycin did not influence constitutive β-lactamase or derepression of other inducible enzymes in this same strain. These results suggest that clindamycin may selectively inhibit synthesis of β-lactamase under repressor control in some bacteria without affecting synthesis of other proteins or replication. Such selective inhibition may provide a new approach for the enhancement of the antibacterial activity of certain β-lactam antibiotics.

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalJournal of Antimicrobial Chemotherapy
Volume12
Issue numberSUPPL. C
StatePublished - 1983

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Clindamycin
Gram-Negative Bacteria
Lactams
Enterobacter
Anti-Bacterial Agents
Pseudomonas aeruginosa
Bacillus
Bacteria
Enzymes
Growth
Proteins

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Pharmacology

Cite this

Effects of clindamycin on derepression of β-lactamases in Gram-negative bacteria. / Sanders, C. C.; Sanders, W. E.; Goering, Richard V.

In: Journal of Antimicrobial Chemotherapy, Vol. 12, No. SUPPL. C, 1983, p. 97-104.

Research output: Contribution to journalArticle

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