Effects of hypergravity on the prenatal development of peripheral vestibulocerebellar afferent fibers

Laura Bruce, J. M. Burke, J. A. Dobrowolska

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The relationship between vestibular stimulation and the distribution of peripheral vestibulocerebellar sensory fibers was studied in embryonic rats that developed in normal gravity (1G), 1.75G, 2.0G, or rotational environments from 10 to 20 days of gestation. Subsequently a fluorescent neuronal tracer was applied to the cerebellum, and allowed to diffuse retrogradely to the vestibular periphery. The distribution of labeled fibers and terminals in the posterior vertical canal and the utricle was analyzed. Sensory fibers in the rotation- and hypergravity-exposed embryos of the posterior semicircular canal and utricle displayed fewer long extending fibers and more terminal fields, suggesting faster rates of maturation as compared to the synchronous controls. Hypergravity exposures in the posterior canal caused increased terminal formation in the central zone of the cristae, and in the utricle caused increased terminal formation, including calyces, in the medial extrastriolar zone. These results show the importance of the vestibular environment in the development of peripheral vestibular innervation.

Original languageEnglish
Pages (from-to)1041-1051
Number of pages11
JournalAdvances in Space Research
Volume38
Issue number6
DOIs
StatePublished - 2006

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utricle
high gravity environments
Canals
canal
canals
fibers
Fibers
semicircular canals
cerebellum
embryos
stimulation
pregnancy
rats
tracers
Rats
maturation
embryo
Gravitation
tracer
gravity

All Science Journal Classification (ASJC) codes

  • Space and Planetary Science
  • Astronomy and Astrophysics

Cite this

Effects of hypergravity on the prenatal development of peripheral vestibulocerebellar afferent fibers. / Bruce, Laura; Burke, J. M.; Dobrowolska, J. A.

In: Advances in Space Research, Vol. 38, No. 6, 2006, p. 1041-1051.

Research output: Contribution to journalArticle

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