Effects of implantable cardioverter defibrillator implantation and shock application on serum endothelin-1 and big-endothelin levels

Andrea Szucs, Katalin Keltai, Endre Zima, Hajnalka Vágó, Pál Soós, Attila Róka, Zoltán Szabolcs, László Gellér, Béla Merkely

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4 Scopus citations

Abstract

The incidence of ventricular tachyarrhythmias in the early post-operative period following implantable cardioverter-defibrillator (ICD) implantation is relatively high compared with that in control periods. Since endothelin-1 (ET-1) has been proven to be an endogenous arrhythmogenic substance, we investigated the changes in serum ET-1 and big-ET levels in patients undergoing ICD implantation. Serum concentrations of ET-1 and big-ET were measured in 14 patients with various heart diseases before the operation, as well as 1 min and 1 h after the last shock therapy. Big-ET levels and the sum of ET-1 and big-ET levels were unchanged immediately after the operation, but had increased significantly by 1 h after implantation (before, 1.57±0.61 pmol/l; 1 min, 1.86±0.87 pmol/l; 1 h, 4.29±1.65 pmol/l for big-ET; before, 3.44±1.07 pmol/l; 1 min, 3.79±1.29 pmol/l; 1 h, 6.36±2.03 pmol/1 for big-ET+ET-1). There was a significant correlation between left ventricular ejection fraction and big-ET level measured 1 h after the last shock delivery (r = -0.542, P < 0.05). We conclude that the increased big-ET level observed 1 h after the last induction and shock therapy of ventricular fibrillation might have a pathophysiological role in the increased incidence of post-operative spontaneous ventricular arrhythmias.

Original languageEnglish (US)
Pages (from-to)233S-236S
JournalClinical Science
Volume103
Issue numberSUPPL. 48
DOIs
StatePublished - Aug 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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