Effects of menthol-based counterirritant on quadriceps motoneuron-pool excitability

Daniel H. Huffman, Brian G. Pietrosimone, Terry L. Grindstaff, Joseph M. Hart, Susan A. Saliba, Christopher D. Ingersoll

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Context: Motoneuron-pool facilitation after cryotherapy may be mediated by stimulation of thermoreceptors surrounding a joint. It is unknown whether menthol counterirritants, which also stimulate thermoreceptors, have the same effect on motoneuron-pool excitability (MNPE). Objective: To compare quadriceps MNPE after a menthol-counterirritant application to the anterior knee, a sham counterirritant application, and a control treatment in healthy subjects. Design: A blinded, randomized controlled laboratory study. Setting: Laboratory. Participants: Thirty healthy subjects (16 m, 14 f; 24.1 ± 3.9 y, 170.6 ± 11.4 cm, 72.1 ± 15.6 kg) with no history of lower extremity surgery volunteered for this study. Intervention: Two milliliters of menthol or sham counterirritant was applied to the anterior knee; control subjects received no intervention. Main Outcome Measures: The average vastus medialis normalized Hoffmann reflex (Hmax:Mmax ratio) was used to measure MNPE. Measurements were recorded at 5, 15, 25, and 35 minutes postintervention and compared with baseline measures. Results: Hmax:Mmax ratios for all groups significantly decreased over time (F4,108 = 10.52, P <.001; menthol: baseline = .32 ± .20, 5 min = .29 ± .18, 15 min = .27 ± .18, 25 min = .28 ± .19, 35 min = .27 ± .18; sham: baseline = .46 ± .26, 5 min = .36 ± .20, 15 min = .35 ± .19, 25 min = .35 ± .20, 35 min = .34 ± .18; control: baseline = .48 ± .32, 5 min = .37 ± .27, 15 min = .37 ± .27, 25 min = .37 ± .29, 35 min = .35 ±.28). No significant Group × Time interaction or group differences in Hmax:Mmax were found. Conclusions: Menthol did not affect quadriceps MNPE in healthy subjects.

Original languageEnglish
Pages (from-to)30-40
Number of pages11
JournalJournal of Sport Rehabilitation
Volume19
Issue number1
StatePublished - Feb 2010
Externally publishedYes

Fingerprint

Menthol
Irritants
Motor Neurons
Thermoreceptors
Healthy Volunteers
Knee
Cryotherapy
Quadriceps Muscle
Reflex
Lower Extremity
Joints
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Biophysics

Cite this

Huffman, D. H., Pietrosimone, B. G., Grindstaff, T. L., Hart, J. M., Saliba, S. A., & Ingersoll, C. D. (2010). Effects of menthol-based counterirritant on quadriceps motoneuron-pool excitability. Journal of Sport Rehabilitation, 19(1), 30-40.

Effects of menthol-based counterirritant on quadriceps motoneuron-pool excitability. / Huffman, Daniel H.; Pietrosimone, Brian G.; Grindstaff, Terry L.; Hart, Joseph M.; Saliba, Susan A.; Ingersoll, Christopher D.

In: Journal of Sport Rehabilitation, Vol. 19, No. 1, 02.2010, p. 30-40.

Research output: Contribution to journalArticle

Huffman, DH, Pietrosimone, BG, Grindstaff, TL, Hart, JM, Saliba, SA & Ingersoll, CD 2010, 'Effects of menthol-based counterirritant on quadriceps motoneuron-pool excitability', Journal of Sport Rehabilitation, vol. 19, no. 1, pp. 30-40.
Huffman DH, Pietrosimone BG, Grindstaff TL, Hart JM, Saliba SA, Ingersoll CD. Effects of menthol-based counterirritant on quadriceps motoneuron-pool excitability. Journal of Sport Rehabilitation. 2010 Feb;19(1):30-40.
Huffman, Daniel H. ; Pietrosimone, Brian G. ; Grindstaff, Terry L. ; Hart, Joseph M. ; Saliba, Susan A. ; Ingersoll, Christopher D. / Effects of menthol-based counterirritant on quadriceps motoneuron-pool excitability. In: Journal of Sport Rehabilitation. 2010 ; Vol. 19, No. 1. pp. 30-40.
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abstract = "Context: Motoneuron-pool facilitation after cryotherapy may be mediated by stimulation of thermoreceptors surrounding a joint. It is unknown whether menthol counterirritants, which also stimulate thermoreceptors, have the same effect on motoneuron-pool excitability (MNPE). Objective: To compare quadriceps MNPE after a menthol-counterirritant application to the anterior knee, a sham counterirritant application, and a control treatment in healthy subjects. Design: A blinded, randomized controlled laboratory study. Setting: Laboratory. Participants: Thirty healthy subjects (16 m, 14 f; 24.1 ± 3.9 y, 170.6 ± 11.4 cm, 72.1 ± 15.6 kg) with no history of lower extremity surgery volunteered for this study. Intervention: Two milliliters of menthol or sham counterirritant was applied to the anterior knee; control subjects received no intervention. Main Outcome Measures: The average vastus medialis normalized Hoffmann reflex (Hmax:Mmax ratio) was used to measure MNPE. Measurements were recorded at 5, 15, 25, and 35 minutes postintervention and compared with baseline measures. Results: Hmax:Mmax ratios for all groups significantly decreased over time (F4,108 = 10.52, P <.001; menthol: baseline = .32 ± .20, 5 min = .29 ± .18, 15 min = .27 ± .18, 25 min = .28 ± .19, 35 min = .27 ± .18; sham: baseline = .46 ± .26, 5 min = .36 ± .20, 15 min = .35 ± .19, 25 min = .35 ± .20, 35 min = .34 ± .18; control: baseline = .48 ± .32, 5 min = .37 ± .27, 15 min = .37 ± .27, 25 min = .37 ± .29, 35 min = .35 ±.28). No significant Group × Time interaction or group differences in Hmax:Mmax were found. Conclusions: Menthol did not affect quadriceps MNPE in healthy subjects.",
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N2 - Context: Motoneuron-pool facilitation after cryotherapy may be mediated by stimulation of thermoreceptors surrounding a joint. It is unknown whether menthol counterirritants, which also stimulate thermoreceptors, have the same effect on motoneuron-pool excitability (MNPE). Objective: To compare quadriceps MNPE after a menthol-counterirritant application to the anterior knee, a sham counterirritant application, and a control treatment in healthy subjects. Design: A blinded, randomized controlled laboratory study. Setting: Laboratory. Participants: Thirty healthy subjects (16 m, 14 f; 24.1 ± 3.9 y, 170.6 ± 11.4 cm, 72.1 ± 15.6 kg) with no history of lower extremity surgery volunteered for this study. Intervention: Two milliliters of menthol or sham counterirritant was applied to the anterior knee; control subjects received no intervention. Main Outcome Measures: The average vastus medialis normalized Hoffmann reflex (Hmax:Mmax ratio) was used to measure MNPE. Measurements were recorded at 5, 15, 25, and 35 minutes postintervention and compared with baseline measures. Results: Hmax:Mmax ratios for all groups significantly decreased over time (F4,108 = 10.52, P <.001; menthol: baseline = .32 ± .20, 5 min = .29 ± .18, 15 min = .27 ± .18, 25 min = .28 ± .19, 35 min = .27 ± .18; sham: baseline = .46 ± .26, 5 min = .36 ± .20, 15 min = .35 ± .19, 25 min = .35 ± .20, 35 min = .34 ± .18; control: baseline = .48 ± .32, 5 min = .37 ± .27, 15 min = .37 ± .27, 25 min = .37 ± .29, 35 min = .35 ±.28). No significant Group × Time interaction or group differences in Hmax:Mmax were found. Conclusions: Menthol did not affect quadriceps MNPE in healthy subjects.

AB - Context: Motoneuron-pool facilitation after cryotherapy may be mediated by stimulation of thermoreceptors surrounding a joint. It is unknown whether menthol counterirritants, which also stimulate thermoreceptors, have the same effect on motoneuron-pool excitability (MNPE). Objective: To compare quadriceps MNPE after a menthol-counterirritant application to the anterior knee, a sham counterirritant application, and a control treatment in healthy subjects. Design: A blinded, randomized controlled laboratory study. Setting: Laboratory. Participants: Thirty healthy subjects (16 m, 14 f; 24.1 ± 3.9 y, 170.6 ± 11.4 cm, 72.1 ± 15.6 kg) with no history of lower extremity surgery volunteered for this study. Intervention: Two milliliters of menthol or sham counterirritant was applied to the anterior knee; control subjects received no intervention. Main Outcome Measures: The average vastus medialis normalized Hoffmann reflex (Hmax:Mmax ratio) was used to measure MNPE. Measurements were recorded at 5, 15, 25, and 35 minutes postintervention and compared with baseline measures. Results: Hmax:Mmax ratios for all groups significantly decreased over time (F4,108 = 10.52, P <.001; menthol: baseline = .32 ± .20, 5 min = .29 ± .18, 15 min = .27 ± .18, 25 min = .28 ± .19, 35 min = .27 ± .18; sham: baseline = .46 ± .26, 5 min = .36 ± .20, 15 min = .35 ± .19, 25 min = .35 ± .20, 35 min = .34 ± .18; control: baseline = .48 ± .32, 5 min = .37 ± .27, 15 min = .37 ± .27, 25 min = .37 ± .29, 35 min = .35 ±.28). No significant Group × Time interaction or group differences in Hmax:Mmax were found. Conclusions: Menthol did not affect quadriceps MNPE in healthy subjects.

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