Effects of monoamine oxidase inhibitors on phencyclidine induced stereotyped behavior and brain levels in rats

Thomas F. Murray, A. Horita

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In the present investigation, the effects of the MAO inhibitors, iproniazid, pargyline and tranylcypromine, as well as d-amphetamine or phencyclidine induced stereotyped behavior in rats has been evaluated. We have previously reported that phencyclidine produces a very characteristic stereotyped behavioral syndrome in rats. The possibility of a pharmacokinetic interaction between these compounds was evaluated by measuring the brain levels of phencyclidine and its metabolites in the various pretreatment groups.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalProceedings of the Western Pharmacology Society
VolumeVOL. 22
StatePublished - 1979
Externally publishedYes

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Stereotyped Behavior
Phencyclidine
Monoamine Oxidase Inhibitors
Brain
Iproniazid
Tranylcypromine
Pargyline
Dextroamphetamine
Pharmacokinetics

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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