Effects of monoamine oxidase inhibitors on phencyclidine induced stereotyped behavior and brain levels in rats

T. F. Murray; A. Horita

Effects of monoamine oxidase inhibitors on phencyclidine induced stereotyped behavior and brain levels in rats

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Abstract

In the present investigation, the effects of the MAO inhibitors, iproniazid, pargyline and tranylcypromine, as well as d-amphetamine or phencyclidine induced stereotyped behavior in rats has been evaluated. We have previously reported that phencyclidine produces a very characteristic stereotyped behavioral syndrome in rats. The possibility of a pharmacokinetic interaction between these compounds was evaluated by measuring the brain levels of phencyclidine and its metabolites in the various pretreatment groups.

Original language	English (US)
Pages (from-to)	145-147
Number of pages	3
Journal	Proceedings of the Western Pharmacology Society
Volume	VOL. 22
State	Published - Jan 1 1979
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

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abstract = "In the present investigation, the effects of the MAO inhibitors, iproniazid, pargyline and tranylcypromine, as well as d-amphetamine or phencyclidine induced stereotyped behavior in rats has been evaluated. We have previously reported that phencyclidine produces a very characteristic stereotyped behavioral syndrome in rats. The possibility of a pharmacokinetic interaction between these compounds was evaluated by measuring the brain levels of phencyclidine and its metabolites in the various pretreatment groups.",

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