Effects of platelet activating factor on cyclic AMP accumulation in human lymphocytes

S. Wang; R. G. Townley

Effects of platelet activating factor on cyclic AMP accumulation in human lymphocytes

S. Wang, R. G. Townley

Department of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The in vitro effects of platelet activating factor (PAF) on intracellular adenosine 3',5'-cyclic adenosine monophosphate (cAMP) accumulation were assessed in human lymphocytes in ten healthy volunteers and in eight asthmatic patients. Platelet activating factor to increased intracellular cAMP in both groups. In addition, PAF also enhanced the effects of isoproterenol and theophylline on intracellular cAMP production in these two groups.

Original language	English (US)
Pages (from-to)	140-142
Number of pages	3
Journal	Annals of Allergy
Volume	69
Issue number	2
State	Published - Jan 1 1992

All Science Journal Classification (ASJC) codes

Immunology and Allergy

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title = "Effects of platelet activating factor on cyclic AMP accumulation in human lymphocytes",

abstract = "The in vitro effects of platelet activating factor (PAF) on intracellular adenosine 3',5'-cyclic adenosine monophosphate (cAMP) accumulation were assessed in human lymphocytes in ten healthy volunteers and in eight asthmatic patients. Platelet activating factor to increased intracellular cAMP in both groups. In addition, PAF also enhanced the effects of isoproterenol and theophylline on intracellular cAMP production in these two groups.",

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AB - The in vitro effects of platelet activating factor (PAF) on intracellular adenosine 3',5'-cyclic adenosine monophosphate (cAMP) accumulation were assessed in human lymphocytes in ten healthy volunteers and in eight asthmatic patients. Platelet activating factor to increased intracellular cAMP in both groups. In addition, PAF also enhanced the effects of isoproterenol and theophylline on intracellular cAMP production in these two groups.

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