Effects of resistance exercise and creatine supplementation on myasthenia gravis

A case study

J. R. Stout, Joan Eckerson, E. May, C. Coulter, G. E. Bradley-Popovich

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: The purpose of this case study was to determine the effects of 15 wk of resistance exercise and creatine (Cr) supplementation on body composition, training volume, peak strength, and complete blood chemistry in a patient with myasthenia gravis (MG). Methods: The patient was a 26-yr-old man who was taking prednisone and azathioprine for his condition. The patient self-administered 5 g of Cr per day in addition to resistance exercise 3 times per week. Fasting blood samples were obtained and body weight (BW) and fat free mass (FFM; via hydrostatic weighing) were measured before and after training and Cr supplementation. In addition, isokinetic (Cybex II) peak strength for leg extension (LE), leg flexion (LF), and volume load (repetition x mass lifted) for the first and last resistance training session were determined. Results: After Cr supplementation and training, the results demonstrated increases in BW (6.8%), FFM (4.3%), upper body volume load (37.0%), lower body volume load (15.0%), and peak strength for LE (37.0%) and LF (12.5%). Moreover, blood chemistry values remained within normal limits for the duration of the 15-wk study. Conclusion: These data suggest that resistance exercise plus Cr supplementation may promote gains in strength and FFM in patients with MG.

Original languageEnglish
Pages (from-to)869-872
Number of pages4
JournalMedicine and Science in Sports and Exercise
Volume33
Issue number6
StatePublished - 2001

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Creatine
Myasthenia Gravis
Exercise
Leg
Body Weight
Resistance Training
Azathioprine
Prednisone
Body Composition
Adipose Tissue
Fasting

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Orthopedics and Sports Medicine

Cite this

Effects of resistance exercise and creatine supplementation on myasthenia gravis : A case study. / Stout, J. R.; Eckerson, Joan; May, E.; Coulter, C.; Bradley-Popovich, G. E.

In: Medicine and Science in Sports and Exercise, Vol. 33, No. 6, 2001, p. 869-872.

Research output: Contribution to journalArticle

Stout, J. R. ; Eckerson, Joan ; May, E. ; Coulter, C. ; Bradley-Popovich, G. E. / Effects of resistance exercise and creatine supplementation on myasthenia gravis : A case study. In: Medicine and Science in Sports and Exercise. 2001 ; Vol. 33, No. 6. pp. 869-872.
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