Effects of Vitamin e on Bone Biomechanical and Histomorphometric Parameters in Ovariectomized Rats

Rafaela G. Feresin, Sarah A. Johnson, Marcus L. Elam, Jeong Su Kim, Dania A. Khalil, Edralin A. Lucas, Brenda J. Smith, Mark E. Payton, Mohammed P. Akhter, Bahram H. Arjmandi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The present study examined the dose-dependent effect of vitamin E in reversing bone loss in ovariectomized (Ovx) rats. Sprague-Dawley rats were either Sham-operated (Sham) or Ovx and fed control diet for 120 days to lose bone. Subsequently, rats were divided into 5 groups (n=12/group): Sham, Ovx-control, low dose (Ovx + 300 mg/kg diet; LD), medium dose (Ovx + 525 mg/kg diet; MD), and high dose (Ovx + 750 mg/kg diet; HD) of vitamin E and sacrificed after 100 days. Animals receiving MD and HD of vitamin E had increased serum alkaline phosphatase compared to the Ovx-control group. Bone histomorphometry analysis indicated a decrease in bone resorption as well as increased bone formation and mineralization in the Ovx groups supplemented with MD and HD of vitamin E. Microcomputed tomography findings indicated no effects of vitamin E on trabecular bone of fifth lumbar vertebrae. Animals receiving HD of vitamin E had enhanced fourth lumbar vertebra quality as evidenced by improved ultimate and yield load and stress when compared to Ovx-control group. These findings demonstrate that vitamin E improves bone quality, attenuates bone resorption, and enhances the rate of bone formation while being unable to restore bone density and trabecular bone structure.

Original languageEnglish
Article number825985
JournalJournal of Osteoporosis
Volume2013
DOIs
StatePublished - 2013

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Vitamin E
Vitamins
Bone and Bones
Diet
Lumbar Vertebrae
Bone Resorption
Osteogenesis
Physiologic Calcification
X-Ray Microtomography
Control Groups
Bone Density
Alkaline Phosphatase
Sprague Dawley Rats
Serum

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Feresin, R. G., Johnson, S. A., Elam, M. L., Kim, J. S., Khalil, D. A., Lucas, E. A., ... Arjmandi, B. H. (2013). Effects of Vitamin e on Bone Biomechanical and Histomorphometric Parameters in Ovariectomized Rats. Journal of Osteoporosis, 2013, [825985]. https://doi.org/10.1155/2013/825985

Effects of Vitamin e on Bone Biomechanical and Histomorphometric Parameters in Ovariectomized Rats. / Feresin, Rafaela G.; Johnson, Sarah A.; Elam, Marcus L.; Kim, Jeong Su; Khalil, Dania A.; Lucas, Edralin A.; Smith, Brenda J.; Payton, Mark E.; Akhter, Mohammed P.; Arjmandi, Bahram H.

In: Journal of Osteoporosis, Vol. 2013, 825985, 2013.

Research output: Contribution to journalArticle

Feresin, RG, Johnson, SA, Elam, ML, Kim, JS, Khalil, DA, Lucas, EA, Smith, BJ, Payton, ME, Akhter, MP & Arjmandi, BH 2013, 'Effects of Vitamin e on Bone Biomechanical and Histomorphometric Parameters in Ovariectomized Rats', Journal of Osteoporosis, vol. 2013, 825985. https://doi.org/10.1155/2013/825985
Feresin, Rafaela G. ; Johnson, Sarah A. ; Elam, Marcus L. ; Kim, Jeong Su ; Khalil, Dania A. ; Lucas, Edralin A. ; Smith, Brenda J. ; Payton, Mark E. ; Akhter, Mohammed P. ; Arjmandi, Bahram H. / Effects of Vitamin e on Bone Biomechanical and Histomorphometric Parameters in Ovariectomized Rats. In: Journal of Osteoporosis. 2013 ; Vol. 2013.
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