Efficacy and Safety of Intragastric Balloon (IGB) in Non-alcoholic Fatty Liver Disease (NAFLD): a Comprehensive Review and Meta-analysis

Saurabh Chandan, Babu P. Mohan, Shahab R. Khan, Antonio Facciorusso, Daryl Ramai, Lena L. Kassab, Neil Bhogal, Ravishankar Asokkumar, Gortrand Lopez-Nava, Stephanie McDonough, Douglas G. Adler

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Intragastric balloon (IGB) therapy has shown efficacy in weight loss but its role in NAFLD remains unknown. We conducted a systematic review and meta-analysis to evaluate the efficacy of IGB in NAFLD. Meta-analysis was performed to estimate the pooled proportion of patients with improvement in steatosis as determined by imaging and histology following IGB placement. Nine studies were included in our analysis. Four hundred forty-two IGBs were placed. Improvement in steatosis was seen in 79.2% of patients and NAS in 83.5% of patients, and HOMA-IR score improved in 64.5% of patients. A reduction in liver volume by CT scan was noticed in 93.9% of patients undergoing IGB placement. IGB is an effective and safe short-term therapeutic modality for patients with NAFLD.

Original languageEnglish (US)
Pages (from-to)1271-1279
Number of pages9
JournalObesity Surgery
Volume31
Issue number3
DOIs
StatePublished - Mar 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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