TY - JOUR
T1 - Elastic properties of osteoporotic bone measured by scanning acoustic microscopy
AU - Hasegawa, K.
AU - Turner, C. H.
AU - Recker, R. R.
AU - Wu, E.
AU - Burr, D. B.
N1 - Funding Information:
Acknowledgments: This study was supported by the National Institutes of Health (Grants #AR39708. AR40688. and AR40655). the Biomechanics and Biomateria1s Research Center of Indiana University and the Indianapolis Center for Advanced Research. We thank A. M. Parfitt. Bone and Mineral Research Laboratory. Henry Ford Hospital. Detroit. Michigan. for kindly providing the specimens from age· matched normal and osteoporotic subjects.
PY - 1995/1
Y1 - 1995/1
N2 - A combination of low bone mass and decreased bone quality underlies osteoporotic fracture. We used scanning acoustic microscopy, a nondestructive method for assessing bone elasticity at a resolution of about 60 μm, to estimate the quality of biopsied iliac bones. We compared the acoustic velocities and bone volumes among premenopausal normal (n = 10), osteoporotic (n = 20), and postmenopausal normal (n = 10) subjects, the latter age-matched to the osteoporotic subjects. The acoustic measurements were highly reproducible (coefficient of variation = 0.32%). Bone volume of osteoporotic subjects (BV/TV = 13.3%) was lower than that of premenopausal and age-matched normals (BV/TV = 22.8%, p = 0.0007; BV/TV = 24.8%, p = 0.0004, respectively). Acoustic velocity of osteoporotic bone was 6.2% lower than that of age-matched normal bone (p <0.02), but 3.4% higher than that of bone from premenopausal normal women. The lower acoustic velocity of osteoporotic bone than that of age-matched normal subjects implies that osteoporosis involves altered tissue elasticity. However, the lowest acoustic velocities were measured in premenopausal normal subjects. This unexpected result may indicate a complex relationship between tissue level properties and fragility in bone.
AB - A combination of low bone mass and decreased bone quality underlies osteoporotic fracture. We used scanning acoustic microscopy, a nondestructive method for assessing bone elasticity at a resolution of about 60 μm, to estimate the quality of biopsied iliac bones. We compared the acoustic velocities and bone volumes among premenopausal normal (n = 10), osteoporotic (n = 20), and postmenopausal normal (n = 10) subjects, the latter age-matched to the osteoporotic subjects. The acoustic measurements were highly reproducible (coefficient of variation = 0.32%). Bone volume of osteoporotic subjects (BV/TV = 13.3%) was lower than that of premenopausal and age-matched normals (BV/TV = 22.8%, p = 0.0007; BV/TV = 24.8%, p = 0.0004, respectively). Acoustic velocity of osteoporotic bone was 6.2% lower than that of age-matched normal bone (p <0.02), but 3.4% higher than that of bone from premenopausal normal women. The lower acoustic velocity of osteoporotic bone than that of age-matched normal subjects implies that osteoporosis involves altered tissue elasticity. However, the lowest acoustic velocities were measured in premenopausal normal subjects. This unexpected result may indicate a complex relationship between tissue level properties and fragility in bone.
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U2 - 10.1016/8756-3282(95)80016-J
DO - 10.1016/8756-3282(95)80016-J
M3 - Article
C2 - 7742089
AN - SCOPUS:0029127164
VL - 16
SP - 85
EP - 90
JO - Bone
JF - Bone
SN - 8756-3282
IS - 1
ER -