Electrical stimulation treatment of dog's denervated orbicularis oculi muscle

G. M. Salerno, G. A. McClellan, J. N. Bleicher, B. V. Stromberg, Shih-Chuan Cheng

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In this investigation, the electrophysiology and pathology of denervated orbicularis oculi muscles have been studied in dogs during chronic electrical stimulation. The orbicularis oculi muscles were unilaterally denervated in 8 dogs, and 4 of these muscles were directly stimulated on a daily basis for 75 days. No difference in minimum stimulus intensities evoking orbicularis oculi muscle twitch contraction appeared between denervated treated and nontreated muscles. A significant reduction of minimum stimulus intensities evoking upper eyelid complete closure (blink), however, was found in the denervated treated muscles between 10 and 30 days (p < 0.01). At 28 and 75 days, orbicularis oculi muscle biopsies showed no difference in muscle fiber diameter between denervated treated and nontreated muscles. At 75 days, type II muscle fiber distribution, however, was significantly increased in denervated treated muscles compared with denervated nontreated muscles (p < 0.01). These findings of orbicularis oculi muscle electrophysiology were consistent with a transient reversal of denervation changes by electrical stimulation, partially supported by muscle biopsies.

Original languageEnglish (US)
Pages (from-to)431-440
Number of pages10
JournalAnnals of Plastic Surgery
Volume26
Issue number5
StatePublished - 1991

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Electric Stimulation
Dogs
Muscles
Electrophysiology
Fast-Twitch Muscle Fibers
Biopsy
Denervation
Eyelids
Muscle Contraction
Pathology

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Salerno, G. M., McClellan, G. A., Bleicher, J. N., Stromberg, B. V., & Cheng, S-C. (1991). Electrical stimulation treatment of dog's denervated orbicularis oculi muscle. Annals of Plastic Surgery, 26(5), 431-440.

Electrical stimulation treatment of dog's denervated orbicularis oculi muscle. / Salerno, G. M.; McClellan, G. A.; Bleicher, J. N.; Stromberg, B. V.; Cheng, Shih-Chuan.

In: Annals of Plastic Surgery, Vol. 26, No. 5, 1991, p. 431-440.

Research output: Contribution to journalArticle

Salerno, GM, McClellan, GA, Bleicher, JN, Stromberg, BV & Cheng, S-C 1991, 'Electrical stimulation treatment of dog's denervated orbicularis oculi muscle', Annals of Plastic Surgery, vol. 26, no. 5, pp. 431-440.
Salerno GM, McClellan GA, Bleicher JN, Stromberg BV, Cheng S-C. Electrical stimulation treatment of dog's denervated orbicularis oculi muscle. Annals of Plastic Surgery. 1991;26(5):431-440.
Salerno, G. M. ; McClellan, G. A. ; Bleicher, J. N. ; Stromberg, B. V. ; Cheng, Shih-Chuan. / Electrical stimulation treatment of dog's denervated orbicularis oculi muscle. In: Annals of Plastic Surgery. 1991 ; Vol. 26, No. 5. pp. 431-440.
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