Electrogenerated Chemiluminescent Detection of Polyamines on a Microfluidic Device Using Micromolded Carbon Paste Microelectrodes

Erin M. Gross, Emily R. Lowry, Leah V. Schaffer, Charles S. Henry

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A simple, sensitive, and rapid electrochemiluminescent (ECL) method was developed for the detection of several polyamines on a microfluidic chip. Rapid prototyping of poly(dimethylsiloxane) was used to fabricate flow channels and carbon paste microelectrodes. These devices are easily fabricated and amenable to ECL detection due to their planar and optically transparent nature. The ECL reaction between tris(2,2′-bipyridyl)ruthenium(II) and amine-containing co-reactants was used to generate the ECL signal. Experimental parameters were optimized and low micromolar limits of detection (S/N=3) were determined for four different polyamines. The method was successfully used to determine the concentration of spermine in milk samples.

Original languageEnglish (US)
JournalElectroanalysis
DOIs
StateAccepted/In press - 2022

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Electrochemistry

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