Elevation of neutrophil chemotactic activity in the human serum and the decreased number of neutrophils after platelet-activating factor inhalation

H. Miyagawa, M. Nabe, R. J. Hopp, Devendra K. Agrawal, Againdra K. Bewtra, R. G. Townley

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Abstract

We previously reported a significant decrease in neutrophils at 5 min and an increased number of neutrophils at 15 min after PAF-acether inhalation. To investigate the mechanism, we measured the neutrophil chemotactic activity of the sera. Neutrophil chemotactic activity (NCA) of the serum at 5 min was greater than at baseline (p <0.01) or at 15 min (p <0.05). Furthermore, we investigated the correlation between the change in NCA and decreased number of neutrophils. A significant correlation was found between these two at 5 min (r = 0.751, p <0.05). These data suggest that an elevation of NCA may play an important role in the decrease of circulating neutrophils after PAF-acether inhalation.

Original languageEnglish
Pages (from-to)199-202
Number of pages4
JournalInternational Archives of Allergy and Applied Immunology
Volume92
Issue number2
StatePublished - 1990

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Platelet Activating Factor
Human Activities
Inhalation
Neutrophils
Serum

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

Cite this

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title = "Elevation of neutrophil chemotactic activity in the human serum and the decreased number of neutrophils after platelet-activating factor inhalation",
abstract = "We previously reported a significant decrease in neutrophils at 5 min and an increased number of neutrophils at 15 min after PAF-acether inhalation. To investigate the mechanism, we measured the neutrophil chemotactic activity of the sera. Neutrophil chemotactic activity (NCA) of the serum at 5 min was greater than at baseline (p <0.01) or at 15 min (p <0.05). Furthermore, we investigated the correlation between the change in NCA and decreased number of neutrophils. A significant correlation was found between these two at 5 min (r = 0.751, p <0.05). These data suggest that an elevation of NCA may play an important role in the decrease of circulating neutrophils after PAF-acether inhalation.",
author = "H. Miyagawa and M. Nabe and Hopp, {R. J.} and Agrawal, {Devendra K.} and Bewtra, {Againdra K.} and Townley, {R. G.}",
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T1 - Elevation of neutrophil chemotactic activity in the human serum and the decreased number of neutrophils after platelet-activating factor inhalation

AU - Miyagawa, H.

AU - Nabe, M.

AU - Hopp, R. J.

AU - Agrawal, Devendra K.

AU - Bewtra, Againdra K.

AU - Townley, R. G.

PY - 1990

Y1 - 1990

N2 - We previously reported a significant decrease in neutrophils at 5 min and an increased number of neutrophils at 15 min after PAF-acether inhalation. To investigate the mechanism, we measured the neutrophil chemotactic activity of the sera. Neutrophil chemotactic activity (NCA) of the serum at 5 min was greater than at baseline (p <0.01) or at 15 min (p <0.05). Furthermore, we investigated the correlation between the change in NCA and decreased number of neutrophils. A significant correlation was found between these two at 5 min (r = 0.751, p <0.05). These data suggest that an elevation of NCA may play an important role in the decrease of circulating neutrophils after PAF-acether inhalation.

AB - We previously reported a significant decrease in neutrophils at 5 min and an increased number of neutrophils at 15 min after PAF-acether inhalation. To investigate the mechanism, we measured the neutrophil chemotactic activity of the sera. Neutrophil chemotactic activity (NCA) of the serum at 5 min was greater than at baseline (p <0.01) or at 15 min (p <0.05). Furthermore, we investigated the correlation between the change in NCA and decreased number of neutrophils. A significant correlation was found between these two at 5 min (r = 0.751, p <0.05). These data suggest that an elevation of NCA may play an important role in the decrease of circulating neutrophils after PAF-acether inhalation.

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