Elevation of neutrophil chemotactic activity in the human serum and the decreased number of neutrophils after platelet-activating factor inhalation

H. Miyagawa; M. Nabe; R. J. Hopp; D. K. Agrawal; A. K. Bewtra; R. G. Townley

Elevation of neutrophil chemotactic activity in the human serum and the decreased number of neutrophils after platelet-activating factor inhalation

H. Miyagawa, M. Nabe, R. J. Hopp, D. K. Agrawal, A. K. Bewtra, R. G. Townley

Department of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We previously reported a significant decrease in neutrophils at 5 min and an increased number of neutrophils at 15 min after PAF-acether inhalation. To investigate the mechanism, we measured the neutrophil chemotactic activity of the sera. Neutrophil chemotactic activity (NCA) of the serum at 5 min was greater than at baseline (p <0.01) or at 15 min (p <0.05). Furthermore, we investigated the correlation between the change in NCA and decreased number of neutrophils. A significant correlation was found between these two at 5 min (r = 0.751, p <0.05). These data suggest that an elevation of NCA may play an important role in the decrease of circulating neutrophils after PAF-acether inhalation.

Original language	English (US)
Pages (from-to)	199-202
Number of pages	4
Journal	International Archives of Allergy and Applied Immunology
Volume	92
Issue number	2
State	Published - Jan 1 1990

All Science Journal Classification (ASJC) codes

Immunology and Allergy

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Elevation of neutrophil chemotactic activity in the human serum and the decreased number of neutrophils after platelet-activating factor inhalation. / Miyagawa, H.; Nabe, M.; Hopp, R. J.; Agrawal, D. K.; Bewtra, A. K.; Townley, R. G.

In: International Archives of Allergy and Applied Immunology, Vol. 92, No. 2, 01.01.1990, p. 199-202.

Research output: Contribution to journal › Article › peer-review

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title = "Elevation of neutrophil chemotactic activity in the human serum and the decreased number of neutrophils after platelet-activating factor inhalation",

abstract = "We previously reported a significant decrease in neutrophils at 5 min and an increased number of neutrophils at 15 min after PAF-acether inhalation. To investigate the mechanism, we measured the neutrophil chemotactic activity of the sera. Neutrophil chemotactic activity (NCA) of the serum at 5 min was greater than at baseline (p <0.01) or at 15 min (p <0.05). Furthermore, we investigated the correlation between the change in NCA and decreased number of neutrophils. A significant correlation was found between these two at 5 min (r = 0.751, p <0.05). These data suggest that an elevation of NCA may play an important role in the decrease of circulating neutrophils after PAF-acether inhalation.",

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AU - Bewtra, A. K.

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