Abstract
We previously reported a significant decrease in neutrophils at 5 min and an increased number of neutrophils at 15 min after PAF-acether inhalation. To investigate the mechanism, we measured the neutrophil chemotactic activity of the sera. Neutrophil chemotactic activity (NCA) of the serum at 5 min was greater than at baseline (p <0.01) or at 15 min (p <0.05). Furthermore, we investigated the correlation between the change in NCA and decreased number of neutrophils. A significant correlation was found between these two at 5 min (r = 0.751, p <0.05). These data suggest that an elevation of NCA may play an important role in the decrease of circulating neutrophils after PAF-acether inhalation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 199-202 |
| Number of pages | 4 |
| Journal | International Archives of Allergy and Applied Immunology |
| Volume | 92 |
| Issue number | 2 |
| State | Published - Jan 1 1990 |
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
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Miyagawa, H., Nabe, M., Hopp, R. J., Agrawal, D. K., Bewtra, A. K., & Townley, R. G. (1990). Elevation of neutrophil chemotactic activity in the human serum and the decreased number of neutrophils after platelet-activating factor inhalation. International Archives of Allergy and Applied Immunology, 92(2), 199-202.