Emergence of carbapenem resistance in Pseudomonas aeruginosa isolates from a patient with cystic fibrosis in the absence of carbapenem therapy

Daniel J. Wolter, Dee Acquazzino, Richard V. Goering, Paul Sammut, Noha Khalaf, Nancy D. Hanson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The emergence of carbapenem-resistant Pseudomonas aeruginosa in the lung of a patient with cystic fibrosis was evaluated. A single strain of P. aeruginosa persisted during a 3-year study despite antipseudomonal treatment. A stepwise decrease in carbapenem susceptibility leading to resistance was observed in the absence of carbapenem treatment. These data suggest that chronic exposure to unrelated drug classes may be an important determinant for the emergence of carbapenem resistance in P. aeruginosa.

Original languageEnglish
JournalClinical Infectious Diseases
Volume46
Issue number12
DOIs
StatePublished - Jun 15 2008

Fingerprint

Carbapenems
Cystic Fibrosis
Pseudomonas aeruginosa
Therapeutics
Lung
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Microbiology (medical)
  • Medicine(all)

Cite this

Emergence of carbapenem resistance in Pseudomonas aeruginosa isolates from a patient with cystic fibrosis in the absence of carbapenem therapy. / Wolter, Daniel J.; Acquazzino, Dee; Goering, Richard V.; Sammut, Paul; Khalaf, Noha; Hanson, Nancy D.

In: Clinical Infectious Diseases, Vol. 46, No. 12, 15.06.2008.

Research output: Contribution to journalArticle

@article{5bf24380fca54322bc0743fec51ea1d7,
title = "Emergence of carbapenem resistance in Pseudomonas aeruginosa isolates from a patient with cystic fibrosis in the absence of carbapenem therapy",
abstract = "The emergence of carbapenem-resistant Pseudomonas aeruginosa in the lung of a patient with cystic fibrosis was evaluated. A single strain of P. aeruginosa persisted during a 3-year study despite antipseudomonal treatment. A stepwise decrease in carbapenem susceptibility leading to resistance was observed in the absence of carbapenem treatment. These data suggest that chronic exposure to unrelated drug classes may be an important determinant for the emergence of carbapenem resistance in P. aeruginosa.",
author = "Wolter, {Daniel J.} and Dee Acquazzino and Goering, {Richard V.} and Paul Sammut and Noha Khalaf and Hanson, {Nancy D.}",
year = "2008",
month = "6",
day = "15",
doi = "10.1086/588484",
language = "English",
volume = "46",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - Emergence of carbapenem resistance in Pseudomonas aeruginosa isolates from a patient with cystic fibrosis in the absence of carbapenem therapy

AU - Wolter, Daniel J.

AU - Acquazzino, Dee

AU - Goering, Richard V.

AU - Sammut, Paul

AU - Khalaf, Noha

AU - Hanson, Nancy D.

PY - 2008/6/15

Y1 - 2008/6/15

N2 - The emergence of carbapenem-resistant Pseudomonas aeruginosa in the lung of a patient with cystic fibrosis was evaluated. A single strain of P. aeruginosa persisted during a 3-year study despite antipseudomonal treatment. A stepwise decrease in carbapenem susceptibility leading to resistance was observed in the absence of carbapenem treatment. These data suggest that chronic exposure to unrelated drug classes may be an important determinant for the emergence of carbapenem resistance in P. aeruginosa.

AB - The emergence of carbapenem-resistant Pseudomonas aeruginosa in the lung of a patient with cystic fibrosis was evaluated. A single strain of P. aeruginosa persisted during a 3-year study despite antipseudomonal treatment. A stepwise decrease in carbapenem susceptibility leading to resistance was observed in the absence of carbapenem treatment. These data suggest that chronic exposure to unrelated drug classes may be an important determinant for the emergence of carbapenem resistance in P. aeruginosa.

UR - http://www.scopus.com/inward/record.url?scp=46249124312&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46249124312&partnerID=8YFLogxK

U2 - 10.1086/588484

DO - 10.1086/588484

M3 - Article

C2 - 18462098

AN - SCOPUS:46249124312

VL - 46

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 12

ER -