Abstract
The emergence of carbapenem-resistant Pseudomonas aeruginosa in the lung of a patient with cystic fibrosis was evaluated. A single strain of P. aeruginosa persisted during a 3-year study despite antipseudomonal treatment. A stepwise decrease in carbapenem susceptibility leading to resistance was observed in the absence of carbapenem treatment. These data suggest that chronic exposure to unrelated drug classes may be an important determinant for the emergence of carbapenem resistance in P. aeruginosa.
| Original language | English |
|---|---|
| Journal | Clinical Infectious Diseases |
| Volume | 46 |
| Issue number | 12 |
| DOIs | |
| State | Published - Jun 15 2008 |
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All Science Journal Classification (ASJC) codes
- Infectious Diseases
- Microbiology (medical)
- Medicine(all)
Cite this
Emergence of carbapenem resistance in Pseudomonas aeruginosa isolates from a patient with cystic fibrosis in the absence of carbapenem therapy. / Wolter, Daniel J.; Acquazzino, Dee; Goering, Richard V.; Sammut, Paul; Khalaf, Noha; Hanson, Nancy D.
In: Clinical Infectious Diseases, Vol. 46, No. 12, 15.06.2008.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Emergence of carbapenem resistance in Pseudomonas aeruginosa isolates from a patient with cystic fibrosis in the absence of carbapenem therapy
AU - Wolter, Daniel J.
AU - Acquazzino, Dee
AU - Goering, Richard V.
AU - Sammut, Paul
AU - Khalaf, Noha
AU - Hanson, Nancy D.
PY - 2008/6/15
Y1 - 2008/6/15
N2 - The emergence of carbapenem-resistant Pseudomonas aeruginosa in the lung of a patient with cystic fibrosis was evaluated. A single strain of P. aeruginosa persisted during a 3-year study despite antipseudomonal treatment. A stepwise decrease in carbapenem susceptibility leading to resistance was observed in the absence of carbapenem treatment. These data suggest that chronic exposure to unrelated drug classes may be an important determinant for the emergence of carbapenem resistance in P. aeruginosa.
AB - The emergence of carbapenem-resistant Pseudomonas aeruginosa in the lung of a patient with cystic fibrosis was evaluated. A single strain of P. aeruginosa persisted during a 3-year study despite antipseudomonal treatment. A stepwise decrease in carbapenem susceptibility leading to resistance was observed in the absence of carbapenem treatment. These data suggest that chronic exposure to unrelated drug classes may be an important determinant for the emergence of carbapenem resistance in P. aeruginosa.
UR - http://www.scopus.com/inward/record.url?scp=46249124312&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=46249124312&partnerID=8YFLogxK
U2 - 10.1086/588484
DO - 10.1086/588484
M3 - Article
C2 - 18462098
AN - SCOPUS:46249124312
VL - 46
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 12
ER -