@article{5bf24380fca54322bc0743fec51ea1d7,
title = "Emergence of carbapenem resistance in Pseudomonas aeruginosa isolates from a patient with cystic fibrosis in the absence of carbapenem therapy",
abstract = "The emergence of carbapenem-resistant Pseudomonas aeruginosa in the lung of a patient with cystic fibrosis was evaluated. A single strain of P. aeruginosa persisted during a 3-year study despite antipseudomonal treatment. A stepwise decrease in carbapenem susceptibility leading to resistance was observed in the absence of carbapenem treatment. These data suggest that chronic exposure to unrelated drug classes may be an important determinant for the emergence of carbapenem resistance in P. aeruginosa.",
author = "Wolter, {Daniel J.} and Dee Acquazzino and Goering, {Richard V.} and Paul Sammut and Noha Khalaf and Hanson, {Nancy D.}",
note = "Funding Information: Financial support. The Children{\textquoteright}s Hospital Foundation; the John A. Wiebe, Jr., Children{\textquoteright}s Healthcare Fund; and the Investigator-Sponsored Study Program of AstraZeneca. Funding Information: Potential conflicts of interest. N.D.H. and D.J.W. have been supported by educational grants from AstraZeneca and Merck. P.S. has been a recent member of a panel of experts sponsored by AstraZeneca. All other authors: no conflicts.",
year = "2008",
month = jun,
day = "15",
doi = "10.1086/588484",
language = "English (US)",
volume = "46",
pages = "e137--e141",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "12",
}