Emerging roles for triggering receptor expressed on myeloid cells receptor family signaling in inflammatory diseases

Christopher J. Pelham, Devendra K. Agrawal

Research output: Contribution to journalReview article

42 Scopus citations


Innate immune receptors represent important therapeutic targets for inflammatory disorders. In particular, the Toll-like receptor (TLR) family has emerged as a promoter of chronic inflammation that contributes to obesity, insulin resistance and atherosclerosis. Importantly, triggering receptor expressed on myeloid cells-1 (TREM-1) has been characterized as an 'amplifier' of TLR2 and TLR4 signaling. TREM-1- and TREM-2-dependent signaling, as opposed to TREM-like transcript-1 (TLT-1 or TREML1), are mediated through association with the transmembrane adaptor DNAX activation protein of 12 kDa (DAP12). Recessive inheritance of rare mutations in DAP12 or TREM-2 results in a disorder called polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy, and surprisingly these subjects are not immunocompromised. Recent progress into the roles of TREM/DAP12 signaling is critically reviewed here with a focus on metabolic, cardiovascular and inflammatory diseases. The expanding repertoire of putative ligands for TREM receptors is also discussed.

Original languageEnglish
Pages (from-to)243-256
Number of pages14
JournalExpert Review of Clinical Immunology
Issue number2
StatePublished - Feb 2014


All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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