Emphasizing the health benefits of vitamin D for those with neurodevelopmental disorders and intellectual disabilities

William B. Grant, Sunil J. Wimalawansa, Michael F. Holick, John J. Cannell, Pawel Pludowski, Joan M. Lappe, Mary Pittaway, Philip May

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

People with neurodevelopmental disorders and intellectual disabilities have much greater health care needs. Mainly staying indoors, such people generally have low 25-hydroxyvitamin D (25(OH)D) concentrations. The Vitamin D Task Force of the American Academy of Developmental Medicine and Dentistry (AADMD) reviewed the evidence of 25(OH)D concentrations that benefit the health of persons with developmental disabilities. Maintaining recommended optimal serum 25(OH)D concentrations year long will benefit skeletal development in infants, children, and adolescents, and benefit musculoskeletal health and neuromuscular coordination in adult patients, and decrease risk of falls. Maintaining optimal concentrations decreases risks and severities of autoimmune diseases, cardiovascular disease, many types of cancer, dementia, types 1 and 2 diabetes mellitus, and respiratory tract infections. Other benefits include improved dental and oral health and improved physical performance. The Task Force recommends that 25(OH)D concentrations for optimal health to be in the range of 75 to 125 nmol/L, which can be achieved using between 800 and 4000 IU/day vitamin D3 and sensible exposure to solar UVB radiation. The paper also discusses the potential risks of higher 25(OH)D concentrations, the evidence from and limitations of randomized controlled trials, and the recommendations by various groups and agencies.

Original languageEnglish (US)
Pages (from-to)1538-1564
Number of pages27
JournalNutrients
Volume7
Issue number3
DOIs
StatePublished - Feb 27 2015

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All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

Grant, W. B., Wimalawansa, S. J., Holick, M. F., Cannell, J. J., Pludowski, P., Lappe, J. M., Pittaway, M., & May, P. (2015). Emphasizing the health benefits of vitamin D for those with neurodevelopmental disorders and intellectual disabilities. Nutrients, 7(3), 1538-1564. https://doi.org/10.3390/nu7031538