TY - JOUR
T1 - Endogenous and ectopic gland induction by FGF-10
AU - Govindarajan, Venkatesh
AU - Ito, Masataka
AU - Makarenkova, Helen P.
AU - Lang, Richard A.
AU - Overbeek, Paul A.
N1 - Funding Information:
We thank Dr. Nobuyuki Itoh for providing the rat FGF-10 cDNA clone and Dr. Clive Dickson for the mouse FGF-7 cDNA clone. We are grateful to Gabriele Schuster for performing the microinjections, Long Vien for assistance in animal husbandry, Barbara Harris for help in histological analyses, Drs. Gerald R. Cunha, Anne Donjacour, and Scott Simonet for providing the FGF-10−/− fetal heads, and Dr. Fred A. Pereira for insightful comments and discussion. We also thank Drs. Norman Greenberg, Jeffrey Rosen, and Randy Johnson for critically reading the manuscript. This work was supported by NIH Grants EY-10448, EY-10803 (P.A.O.), and EY-11234 (R.A.L.).
PY - 2000/9/1
Y1 - 2000/9/1
N2 - FGF-10, a member of the fibroblast growth factor family, is expressed in mesodermally derived cell populations during embryogenesis. During normal ocular development, FGF-10 is expressed in the perioptic mesenchyme adjacent to the Harderian and lacrimal gland primordia. In this report, we provide evidence that FGF-10 is both necessary and sufficient to initiate glandular morphogenesis. Lens-specific expression of FGF-10 was sufficient to induce ectopic ocular glands within the cornea. In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis. (C) 2000 Academic Press.
AB - FGF-10, a member of the fibroblast growth factor family, is expressed in mesodermally derived cell populations during embryogenesis. During normal ocular development, FGF-10 is expressed in the perioptic mesenchyme adjacent to the Harderian and lacrimal gland primordia. In this report, we provide evidence that FGF-10 is both necessary and sufficient to initiate glandular morphogenesis. Lens-specific expression of FGF-10 was sufficient to induce ectopic ocular glands within the cornea. In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis. (C) 2000 Academic Press.
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U2 - 10.1006/dbio.2000.9812
DO - 10.1006/dbio.2000.9812
M3 - Article
C2 - 10964474
AN - SCOPUS:0034284932
VL - 225
SP - 188
EP - 200
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 1
ER -