Endogenous and ectopic gland induction by FGF-10

Venkatesh Govindarajan, Masataka Ito, Helen P. Makarenkova, Richard A. Lang, Paul A. Overbeek

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

FGF-10, a member of the fibroblast growth factor family, is expressed in mesodermally derived cell populations during embryogenesis. During normal ocular development, FGF-10 is expressed in the perioptic mesenchyme adjacent to the Harderian and lacrimal gland primordia. In this report, we provide evidence that FGF-10 is both necessary and sufficient to initiate glandular morphogenesis. Lens-specific expression of FGF-10 was sufficient to induce ectopic ocular glands within the cornea. In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)188-200
Number of pages13
JournalDevelopmental Biology
Volume225
Issue number1
DOIs
StatePublished - Sep 1 2000
Externally publishedYes

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Harderian Gland
Lacrimal Apparatus
Morphogenesis
Fibroblast Growth Factors
Mesoderm
Cornea
Lenses
Embryonic Development
Fetus
Population

All Science Journal Classification (ASJC) codes

  • Developmental Biology

Cite this

Govindarajan, V., Ito, M., Makarenkova, H. P., Lang, R. A., & Overbeek, P. A. (2000). Endogenous and ectopic gland induction by FGF-10. Developmental Biology, 225(1), 188-200. https://doi.org/10.1006/dbio.2000.9812

Endogenous and ectopic gland induction by FGF-10. / Govindarajan, Venkatesh; Ito, Masataka; Makarenkova, Helen P.; Lang, Richard A.; Overbeek, Paul A.

In: Developmental Biology, Vol. 225, No. 1, 01.09.2000, p. 188-200.

Research output: Contribution to journalArticle

Govindarajan, V, Ito, M, Makarenkova, HP, Lang, RA & Overbeek, PA 2000, 'Endogenous and ectopic gland induction by FGF-10', Developmental Biology, vol. 225, no. 1, pp. 188-200. https://doi.org/10.1006/dbio.2000.9812
Govindarajan, Venkatesh ; Ito, Masataka ; Makarenkova, Helen P. ; Lang, Richard A. ; Overbeek, Paul A. / Endogenous and ectopic gland induction by FGF-10. In: Developmental Biology. 2000 ; Vol. 225, No. 1. pp. 188-200.
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