Endogenous and ectopic gland induction by FGF-10

Venkatesh Govindarajan, Masataka Ito, Helen P. Makarenkova, Richard A. Lang, Paul A. Overbeek

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

FGF-10, a member of the fibroblast growth factor family, is expressed in mesodermally derived cell populations during embryogenesis. During normal ocular development, FGF-10 is expressed in the perioptic mesenchyme adjacent to the Harderian and lacrimal gland primordia. In this report, we provide evidence that FGF-10 is both necessary and sufficient to initiate glandular morphogenesis. Lens-specific expression of FGF-10 was sufficient to induce ectopic ocular glands within the cornea. In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)188-200
Number of pages13
JournalDevelopmental Biology
Volume225
Issue number1
DOIs
StatePublished - Sep 1 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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