Abstract
FGF-10, a member of the fibroblast growth factor family, is expressed in mesodermally derived cell populations during embryogenesis. During normal ocular development, FGF-10 is expressed in the perioptic mesenchyme adjacent to the Harderian and lacrimal gland primordia. In this report, we provide evidence that FGF-10 is both necessary and sufficient to initiate glandular morphogenesis. Lens-specific expression of FGF-10 was sufficient to induce ectopic ocular glands within the cornea. In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis. (C) 2000 Academic Press.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 188-200 |
| Number of pages | 13 |
| Journal | Developmental Biology |
| Volume | 225 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 1 2000 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Developmental Biology
- Cell Biology
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Cite this
Govindarajan, V., Ito, M., Makarenkova, H. P., Lang, R. A., & Overbeek, P. A. (2000). Endogenous and ectopic gland induction by FGF-10. Developmental Biology, 225(1), 188-200. https://doi.org/10.1006/dbio.2000.9812