Abstract
FGF-10, a member of the fibroblast growth factor family, is expressed in mesodermally derived cell populations during embryogenesis. During normal ocular development, FGF-10 is expressed in the perioptic mesenchyme adjacent to the Harderian and lacrimal gland primordia. In this report, we provide evidence that FGF-10 is both necessary and sufficient to initiate glandular morphogenesis. Lens-specific expression of FGF-10 was sufficient to induce ectopic ocular glands within the cornea. In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis. (C) 2000 Academic Press.
| Original language | English |
|---|---|
| Pages (from-to) | 188-200 |
| Number of pages | 13 |
| Journal | Developmental Biology |
| Volume | 225 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 1 2000 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Developmental Biology
Cite this
Endogenous and ectopic gland induction by FGF-10. / Govindarajan, Venkatesh; Ito, Masataka; Makarenkova, Helen P.; Lang, Richard A.; Overbeek, Paul A.
In: Developmental Biology, Vol. 225, No. 1, 01.09.2000, p. 188-200.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endogenous and ectopic gland induction by FGF-10
AU - Govindarajan, Venkatesh
AU - Ito, Masataka
AU - Makarenkova, Helen P.
AU - Lang, Richard A.
AU - Overbeek, Paul A.
PY - 2000/9/1
Y1 - 2000/9/1
N2 - FGF-10, a member of the fibroblast growth factor family, is expressed in mesodermally derived cell populations during embryogenesis. During normal ocular development, FGF-10 is expressed in the perioptic mesenchyme adjacent to the Harderian and lacrimal gland primordia. In this report, we provide evidence that FGF-10 is both necessary and sufficient to initiate glandular morphogenesis. Lens-specific expression of FGF-10 was sufficient to induce ectopic ocular glands within the cornea. In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis. (C) 2000 Academic Press.
AB - FGF-10, a member of the fibroblast growth factor family, is expressed in mesodermally derived cell populations during embryogenesis. During normal ocular development, FGF-10 is expressed in the perioptic mesenchyme adjacent to the Harderian and lacrimal gland primordia. In this report, we provide evidence that FGF-10 is both necessary and sufficient to initiate glandular morphogenesis. Lens-specific expression of FGF-10 was sufficient to induce ectopic ocular glands within the cornea. In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis. (C) 2000 Academic Press.
UR - http://www.scopus.com/inward/record.url?scp=0034284932&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034284932&partnerID=8YFLogxK
U2 - 10.1006/dbio.2000.9812
DO - 10.1006/dbio.2000.9812
M3 - Article
C2 - 10964474
AN - SCOPUS:0034284932
VL - 225
SP - 188
EP - 200
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 1
ER -