Endogenous Insulin Secretion Measured by C-peptide in Maturity-Onset Diabetes Controllable by Diet Alone

Marc Rendell, David A. Ross, Helen Mikesell Drew, Joan Zarriello

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Endogenous insulin secretion was quantified in patients with maturity-onset diabetes (MOD) whose diabetes was controllable solely by caloric regulation as primary therapy. Insulin was used adjunctively only and persistent attempts were made to withdraw it as weight loss occurred in response to diet. Insulin secretory capacity was measured by C-peptide response during a standard 100-g oral glucose tolerance test in 24 patients who achieved normalization of plasma glucose level as a result of dietary therapy alone. Summed C-peptide levels for the dietcontrolled diabetic patients was 7.8 ± 0.7 pmole/mL as compared with 6.1 ± 0.45 pmole/mL for a group of ten normalweight, nondiabetic volunteers.

Original languageEnglish
Pages (from-to)1617-1622
Number of pages6
JournalArchives of Internal Medicine
Volume141
Issue number12
DOIs
StatePublished - 1981
Externally publishedYes

Fingerprint

C-Peptide
Type 2 Diabetes Mellitus
Insulin
Diet
Glucose Tolerance Test
Weight Loss
Volunteers
Glucose
Therapeutics

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Endogenous Insulin Secretion Measured by C-peptide in Maturity-Onset Diabetes Controllable by Diet Alone. / Rendell, Marc; Ross, David A.; Drew, Helen Mikesell; Zarriello, Joan.

In: Archives of Internal Medicine, Vol. 141, No. 12, 1981, p. 1617-1622.

Research output: Contribution to journalArticle

Rendell, Marc ; Ross, David A. ; Drew, Helen Mikesell ; Zarriello, Joan. / Endogenous Insulin Secretion Measured by C-peptide in Maturity-Onset Diabetes Controllable by Diet Alone. In: Archives of Internal Medicine. 1981 ; Vol. 141, No. 12. pp. 1617-1622.
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