Endogenous levels of serum estradiol and sex hormone binding globulin determine bone mineral density, bone remodeling, the rate of bone loss, and response to treatment with estrogen in elderly women

Prema B. Rapuri, John Christopher G. Gallagher, Gleb Haynatzki

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

A total of 489 elderly women aged 65-75 yr who participated in a 3-yr, randomized, blinded osteoporosis trial underwent measurements of serum estradiol, bioavailable estradiol, and SHBG. At baseline, bone mineral density (BMD) was lower at the femoral sites (7-19%, P <0.05), total body (6-8%, P <0.05), and spine (5-9%, P = 0.2) in women in the lowest tertile for serum total estradiol [165 nmol/liter), compared with women in the highest tertiles of total estradiol [>13.3 pg/ml (49 pmol/ liter)] and bioavailable estradiol [>4 pg/ml (14 pmol/liter)] or lowest tertile for SHBG (

Original languageEnglish
Pages (from-to)4954-4962
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume89
Issue number10
DOIs
StatePublished - Oct 2004

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Sex Hormone-Binding Globulin
Bone Remodeling
Bone Density
Minerals
Estradiol
Bone
Estrogens
Bone and Bones
Serum
Thigh
Osteoporosis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

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title = "Endogenous levels of serum estradiol and sex hormone binding globulin determine bone mineral density, bone remodeling, the rate of bone loss, and response to treatment with estrogen in elderly women",
abstract = "A total of 489 elderly women aged 65-75 yr who participated in a 3-yr, randomized, blinded osteoporosis trial underwent measurements of serum estradiol, bioavailable estradiol, and SHBG. At baseline, bone mineral density (BMD) was lower at the femoral sites (7-19{\%}, P <0.05), total body (6-8{\%}, P <0.05), and spine (5-9{\%}, P = 0.2) in women in the lowest tertile for serum total estradiol [165 nmol/liter), compared with women in the highest tertiles of total estradiol [>13.3 pg/ml (49 pmol/ liter)] and bioavailable estradiol [>4 pg/ml (14 pmol/liter)] or lowest tertile for SHBG (",
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