Abstract
A total of 489 elderly women aged 65-75 yr who participated in a 3-yr, randomized, blinded osteoporosis trial underwent measurements of serum estradiol, bioavailable estradiol, and SHBG. At baseline, bone mineral density (BMD) was lower at the femoral sites (7-19%, P <0.05), total body (6-8%, P <0.05), and spine (5-9%, P = 0.2) in women in the lowest tertile for serum total estradiol [165 nmol/liter), compared with women in the highest tertiles of total estradiol [>13.3 pg/ml (49 pmol/ liter)] and bioavailable estradiol [>4 pg/ml (14 pmol/liter)] or lowest tertile for SHBG (
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4954-4962 |
| Number of pages | 9 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 89 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2004 |
All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical
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Rapuri, P. B., Gallagher, J. C., & Haynatzki, G. (2004). Endogenous levels of serum estradiol and sex hormone binding globulin determine bone mineral density, bone remodeling, the rate of bone loss, and response to treatment with estrogen in elderly women. Journal of Clinical Endocrinology and Metabolism, 89(10), 4954-4962. https://doi.org/10.1210/jc.2004-0434