TY - JOUR
T1 - Endogenous levels of serum estradiol and sex hormone binding globulin determine bone mineral density, bone remodeling, the rate of bone loss, and response to treatment with estrogen in elderly women
AU - Rapuri, Prema B.
AU - Gallagher, J. Christopher
AU - Haynatzki, Gleb
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/10
Y1 - 2004/10
N2 - A total of 489 elderly women aged 65-75 yr who participated in a 3-yr, randomized, blinded osteoporosis trial underwent measurements of serum estradiol, bioavailable estradiol, and SHBG. At baseline, bone mineral density (BMD) was lower at the femoral sites (7-19%, P <0.05), total body (6-8%, P <0.05), and spine (5-9%, P = 0.2) in women in the lowest tertile for serum total estradiol [165 nmol/liter), compared with women in the highest tertiles of total estradiol [>13.3 pg/ml (49 pmol/ liter)] and bioavailable estradiol [>4 pg/ml (14 pmol/liter)] or lowest tertile for SHBG (
AB - A total of 489 elderly women aged 65-75 yr who participated in a 3-yr, randomized, blinded osteoporosis trial underwent measurements of serum estradiol, bioavailable estradiol, and SHBG. At baseline, bone mineral density (BMD) was lower at the femoral sites (7-19%, P <0.05), total body (6-8%, P <0.05), and spine (5-9%, P = 0.2) in women in the lowest tertile for serum total estradiol [165 nmol/liter), compared with women in the highest tertiles of total estradiol [>13.3 pg/ml (49 pmol/ liter)] and bioavailable estradiol [>4 pg/ml (14 pmol/liter)] or lowest tertile for SHBG (
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U2 - 10.1210/jc.2004-0434
DO - 10.1210/jc.2004-0434
M3 - Article
C2 - 15472191
AN - SCOPUS:6344282429
VL - 89
SP - 4954
EP - 4962
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 10
ER -