Endogenous levels of serum estradiol and sex hormone binding globulin determine bone mineral density, bone remodeling, the rate of bone loss, and response to treatment with estrogen in elderly women

Prema B. Rapuri; J. Christopher Gallagher; Gleb Haynatzki

doi:10.1210/jc.2004-0434

Endogenous levels of serum estradiol and sex hormone binding globulin determine bone mineral density, bone remodeling, the rate of bone loss, and response to treatment with estrogen in elderly women

Prema B. Rapuri, J. Christopher Gallagher, Gleb Haynatzki

Department of Medicine

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

A total of 489 elderly women aged 65-75 yr who participated in a 3-yr, randomized, blinded osteoporosis trial underwent measurements of serum estradiol, bioavailable estradiol, and SHBG. At baseline, bone mineral density (BMD) was lower at the femoral sites (7-19%, P <0.05), total body (6-8%, P <0.05), and spine (5-9%, P = 0.2) in women in the lowest tertile for serum total estradiol [165 nmol/liter), compared with women in the highest tertiles of total estradiol [>13.3 pg/ml (49 pmol/ liter)] and bioavailable estradiol [>4 pg/ml (14 pmol/liter)] or lowest tertile for SHBG (

Original language	English (US)
Pages (from-to)	4954-4962
Number of pages	9
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	89
Issue number	10
DOIs	https://doi.org/10.1210/jc.2004-0434
State	Published - Oct 2004

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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Endogenous levels of serum estradiol and sex hormone binding globulin determine bone mineral density, bone remodeling, the rate of bone loss, and response to treatment with estrogen in elderly women. / Rapuri, Prema B.; Gallagher, J. Christopher; Haynatzki, Gleb.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 89, No. 10, 10.2004, p. 4954-4962.

Research output: Contribution to journal › Article › peer-review

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abstract = "A total of 489 elderly women aged 65-75 yr who participated in a 3-yr, randomized, blinded osteoporosis trial underwent measurements of serum estradiol, bioavailable estradiol, and SHBG. At baseline, bone mineral density (BMD) was lower at the femoral sites (7-19%, P <0.05), total body (6-8%, P <0.05), and spine (5-9%, P = 0.2) in women in the lowest tertile for serum total estradiol [165 nmol/liter), compared with women in the highest tertiles of total estradiol [>13.3 pg/ml (49 pmol/ liter)] and bioavailable estradiol [>4 pg/ml (14 pmol/liter)] or lowest tertile for SHBG (",

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