Endogenous levels of serum estradiol and sex hormone binding globulin determine bone mineral density, bone remodeling, the rate of bone loss, and response to treatment with estrogen in elderly women

Prema B. Rapuri, J. Christopher Gallagher, Gleb Haynatzki

Research output: Contribution to journalArticle

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A total of 489 elderly women aged 65-75 yr who participated in a 3-yr, randomized, blinded osteoporosis trial underwent measurements of serum estradiol, bioavailable estradiol, and SHBG. At baseline, bone mineral density (BMD) was lower at the femoral sites (7-19%, P <0.05), total body (6-8%, P <0.05), and spine (5-9%, P = 0.2) in women in the lowest tertile for serum total estradiol [165 nmol/liter), compared with women in the highest tertiles of total estradiol [>13.3 pg/ml (49 pmol/ liter)] and bioavailable estradiol [>4 pg/ml (14 pmol/liter)] or lowest tertile for SHBG (

Original languageEnglish (US)
Pages (from-to)4954-4962
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Issue number10
StatePublished - Oct 1 2004


All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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