Endometrial histology and bleeding patterns in menopausal women treated with estrogen and continuous or cyclic progestin

C. Bewtra, W. T. Kable, John Christopher G. Gallagher

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Thirty-six postmenopausal women were randomized to three groups in a double-blind, prospective study. All were treated for three months with conjugated estrogens (Premarin), 0.625 mg daily, and three different doses of a progestin (Provera), 2.5 mg daily, 5 mg daily or 5 mg during the last 12 days of a 28-day cycle. We found that the endometrium was maintained in an inactive phase in 100% of the women given continuous daily progestin but in only 25% of those given cyclic progestin. Bleeding occurred in 100% of subjects given cyclic progestin and in 50% of those given continuous progestin; however, bleeding episodes diminished with time in those on continuous progestin. A hormonal regimen that leads to reduced or absent bleeding and an inactive endometrium is preferable for postmenopausal women if estrogen therapy is to be used for the long term after menopause.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalThe Journal of reproductive medicine
Volume33
Issue number2
StatePublished - 1988

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Progestins
Histology
Estrogens
Hemorrhage
Conjugated (USP) Estrogens
Endometrium
Medroxyprogesterone Acetate
Menopause
Double-Blind Method
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

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abstract = "Thirty-six postmenopausal women were randomized to three groups in a double-blind, prospective study. All were treated for three months with conjugated estrogens (Premarin), 0.625 mg daily, and three different doses of a progestin (Provera), 2.5 mg daily, 5 mg daily or 5 mg during the last 12 days of a 28-day cycle. We found that the endometrium was maintained in an inactive phase in 100{\%} of the women given continuous daily progestin but in only 25{\%} of those given cyclic progestin. Bleeding occurred in 100{\%} of subjects given cyclic progestin and in 50{\%} of those given continuous progestin; however, bleeding episodes diminished with time in those on continuous progestin. A hormonal regimen that leads to reduced or absent bleeding and an inactive endometrium is preferable for postmenopausal women if estrogen therapy is to be used for the long term after menopause.",
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