Abstract
Thirty-six postmenopausal women were randomized to three groups in a double-blind, prospective study. All were treated for three months with conjugated estrogens (Premarin), 0.625 mg daily, and three different doses of a progestin (Provera), 2.5 mg daily, 5 mg daily or 5 mg during the last 12 days of a 28-day cycle. We found that the endometrium was maintained in an inactive phase in 100% of the women given continuous daily progestin but in only 25% of those given cyclic progestin. Bleeding occurred in 100% of subjects given cyclic progestin and in 50% of those given continuous progestin; however, bleeding episodes diminished with time in those on continuous progestin. A hormonal regimen that leads to reduced or absent bleeding and an inactive endometrium is preferable for postmenopausal women if estrogen therapy is to be used for the long term after menopause.
| Original language | English |
|---|---|
| Pages (from-to) | 205-208 |
| Number of pages | 4 |
| Journal | The Journal of reproductive medicine |
| Volume | 33 |
| Issue number | 2 |
| State | Published - 1988 |
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All Science Journal Classification (ASJC) codes
- Obstetrics and Gynecology
- Reproductive Medicine
Cite this
Endometrial histology and bleeding patterns in menopausal women treated with estrogen and continuous or cyclic progestin. / Bewtra, C.; Kable, W. T.; Gallagher, John Christopher G.
In: The Journal of reproductive medicine, Vol. 33, No. 2, 1988, p. 205-208.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endometrial histology and bleeding patterns in menopausal women treated with estrogen and continuous or cyclic progestin
AU - Bewtra, C.
AU - Kable, W. T.
AU - Gallagher, John Christopher G.
PY - 1988
Y1 - 1988
N2 - Thirty-six postmenopausal women were randomized to three groups in a double-blind, prospective study. All were treated for three months with conjugated estrogens (Premarin), 0.625 mg daily, and three different doses of a progestin (Provera), 2.5 mg daily, 5 mg daily or 5 mg during the last 12 days of a 28-day cycle. We found that the endometrium was maintained in an inactive phase in 100% of the women given continuous daily progestin but in only 25% of those given cyclic progestin. Bleeding occurred in 100% of subjects given cyclic progestin and in 50% of those given continuous progestin; however, bleeding episodes diminished with time in those on continuous progestin. A hormonal regimen that leads to reduced or absent bleeding and an inactive endometrium is preferable for postmenopausal women if estrogen therapy is to be used for the long term after menopause.
AB - Thirty-six postmenopausal women were randomized to three groups in a double-blind, prospective study. All were treated for three months with conjugated estrogens (Premarin), 0.625 mg daily, and three different doses of a progestin (Provera), 2.5 mg daily, 5 mg daily or 5 mg during the last 12 days of a 28-day cycle. We found that the endometrium was maintained in an inactive phase in 100% of the women given continuous daily progestin but in only 25% of those given cyclic progestin. Bleeding occurred in 100% of subjects given cyclic progestin and in 50% of those given continuous progestin; however, bleeding episodes diminished with time in those on continuous progestin. A hormonal regimen that leads to reduced or absent bleeding and an inactive endometrium is preferable for postmenopausal women if estrogen therapy is to be used for the long term after menopause.
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M3 - Article
C2 - 2832598
AN - SCOPUS:0023831101
VL - 33
SP - 205
EP - 208
JO - The Journal of reproductive medicine
JF - The Journal of reproductive medicine
SN - 0024-7758
IS - 2
ER -