Endoscopic valvuloplasty for GERD

Tomas Martinez-Serna, Richard E. Davis, Rodney Mason, Galen Perdikis, Charles Filipi, Glen Lehman, John Nigro, Patrice Watson

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Background: The transoral, endoscopic route has been suggested as a possible approach for the correction of severe gastroesophageal reflux. Such a procedure would involve no mobilization of the cardia or other structures. The optimal placement, number, and configuration of sutures remains undefined. Methods: With the use of a previously developed endoscopic sewing machine, this study was undertaken in baboons with two suture arrangements immediately below the lower esophageal sphincter. A linear arrangement (group I) and a circular arrangement (group II) were compared. During the 6 months after the procedure, the animals were evaluated using manometry, fluoroscopic barium swallow, upper gastrointestinal endoscopy, and a pressure volume test. Results: A significant increase in lower esophageal sphincter length was demonstrated only in group II (p = 0.010). A significant increase in lower esophageal sphincter pressure was demonstrated only in group I animals (p = 0.008). The abdominal length increased in group I (p = 0.004) and group II (p = 0.004). The yield pressure and yield volume did not differ significantly from those measured previously in control animals. No evidence of reflux, stricture formation, esophagitis, or other pathology was noted. Conclusions: Some manometric parameters associated with gastroesophageal reflux are altered by the endoscopic placement of sutures below the gastroesophageal junction, with no associated serious complications.

Original languageEnglish
Pages (from-to)663-670
Number of pages8
JournalGastrointestinal Endoscopy
Issue number5
StatePublished - 2000

All Science Journal Classification (ASJC) codes

  • Gastroenterology


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