Endothelin-1 levels in ischaemia, reperfusion, and haemorrhagic shock in the canine infrarenal aortic Revascularisation model

John D. Edwards, Peter S. Dovgan, Jane M. Rowley, Devendra K. Agrawal, Patricia E. Thorpe, Thomas E. Adrian

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12 Scopus citations


Endothelin-1 (ET-1) is a potent vasoconstrictive polypeptide produced from vascular endothelial cells. The effects of ischaemia, reperfusion, and exsanguination on plasma ET-1 levels were studied and compared in the mongrel dog after infrarenal aortic cross clamping. Ischaemia produced a trend toward increased ET-1 serum levels (p <0.07 with Bonferroni correction) that did not reach significance. Plasma ET-1 levels were significantly increased during reperfusion and even further elevations were found following exsanguination. We found a 2-3 fold increase in ET-1 levels following reperfusion (Initial 3.19 ± 0.27 pg/ml vs. Reperfusion maximum 6.32 ± 0.72 pg/ml, Bonferroni p <0.01). Haemorrhagic shock was associated with a 3-4 fold increase in ET-1 levels (Initial 3.19 ± 0.27 pg/ml vs. Exsanguination maximum 8.37 ± 0.97 pg/ ml Bonferroni p <0.001). These data reveal that ET-1 is released during reperfusion and exsanguination and may mediate remote vascular events associated with infrarenal aortic cross clamping and acute blood loss.

Original languageEnglish
Pages (from-to)729-734
Number of pages6
JournalEuropean Journal of Vascular Surgery
Issue number6
Publication statusPublished - 1994


All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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