Endothelin-1 levels in ischaemia, reperfusion, and haemorrhagic shock in the canine infrarenal aortic Revascularisation model

John D. Edwards, Peter S. Dovgan, Jane M. Rowley, Devendra K. Agrawal, Patricia E. Thorpe, Thomas E. Adrian

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations

    Abstract

    Endothelin-1 (ET-1) is a potent vasoconstrictive polypeptide produced from vascular endothelial cells. The effects of ischaemia, reperfusion, and exsanguination on plasma ET-1 levels were studied and compared in the mongrel dog after infrarenal aortic cross clamping. Ischaemia produced a trend toward increased ET-1 serum levels (p <0.07 with Bonferroni correction) that did not reach significance. Plasma ET-1 levels were significantly increased during reperfusion and even further elevations were found following exsanguination. We found a 2-3 fold increase in ET-1 levels following reperfusion (Initial 3.19 ± 0.27 pg/ml vs. Reperfusion maximum 6.32 ± 0.72 pg/ml, Bonferroni p <0.01). Haemorrhagic shock was associated with a 3-4 fold increase in ET-1 levels (Initial 3.19 ± 0.27 pg/ml vs. Exsanguination maximum 8.37 ± 0.97 pg/ ml Bonferroni p <0.001). These data reveal that ET-1 is released during reperfusion and exsanguination and may mediate remote vascular events associated with infrarenal aortic cross clamping and acute blood loss.

    Original languageEnglish
    Pages (from-to)729-734
    Number of pages6
    JournalEuropean Journal of Vascular Surgery
    Volume8
    Issue number6
    DOIs
    StatePublished - 1994

    All Science Journal Classification (ASJC) codes

    • Cardiology and Cardiovascular Medicine

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