Abstract
Endothelin-1 (ET-1) is a potent vasoconstrictive polypeptide produced from vascular endothelial cells. The effects of ischaemia, reperfusion, and exsanguination on plasma ET-1 levels were studied and compared in the mongrel dog after infrarenal aortic cross clamping. Ischaemia produced a trend toward increased ET-1 serum levels (p <0.07 with Bonferroni correction) that did not reach significance. Plasma ET-1 levels were significantly increased during reperfusion and even further elevations were found following exsanguination. We found a 2-3 fold increase in ET-1 levels following reperfusion (Initial 3.19 ± 0.27 pg/ml vs. Reperfusion maximum 6.32 ± 0.72 pg/ml, Bonferroni p <0.01). Haemorrhagic shock was associated with a 3-4 fold increase in ET-1 levels (Initial 3.19 ± 0.27 pg/ml vs. Exsanguination maximum 8.37 ± 0.97 pg/ ml Bonferroni p <0.001). These data reveal that ET-1 is released during reperfusion and exsanguination and may mediate remote vascular events associated with infrarenal aortic cross clamping and acute blood loss.
| Original language | English |
|---|---|
| Pages (from-to) | 729-734 |
| Number of pages | 6 |
| Journal | European Journal of Vascular Surgery |
| Volume | 8 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1994 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
Endothelin-1 levels in ischaemia, reperfusion, and haemorrhagic shock in the canine infrarenal aortic Revascularisation model. / Edwards, John D.; Dovgan, Peter S.; Rowley, Jane M.; Agrawal, Devendra K.; Thorpe, Patricia E.; Adrian, Thomas E.
In: European Journal of Vascular Surgery, Vol. 8, No. 6, 1994, p. 729-734.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endothelin-1 levels in ischaemia, reperfusion, and haemorrhagic shock in the canine infrarenal aortic Revascularisation model
AU - Edwards, John D.
AU - Dovgan, Peter S.
AU - Rowley, Jane M.
AU - Agrawal, Devendra K.
AU - Thorpe, Patricia E.
AU - Adrian, Thomas E.
PY - 1994
Y1 - 1994
N2 - Endothelin-1 (ET-1) is a potent vasoconstrictive polypeptide produced from vascular endothelial cells. The effects of ischaemia, reperfusion, and exsanguination on plasma ET-1 levels were studied and compared in the mongrel dog after infrarenal aortic cross clamping. Ischaemia produced a trend toward increased ET-1 serum levels (p <0.07 with Bonferroni correction) that did not reach significance. Plasma ET-1 levels were significantly increased during reperfusion and even further elevations were found following exsanguination. We found a 2-3 fold increase in ET-1 levels following reperfusion (Initial 3.19 ± 0.27 pg/ml vs. Reperfusion maximum 6.32 ± 0.72 pg/ml, Bonferroni p <0.01). Haemorrhagic shock was associated with a 3-4 fold increase in ET-1 levels (Initial 3.19 ± 0.27 pg/ml vs. Exsanguination maximum 8.37 ± 0.97 pg/ ml Bonferroni p <0.001). These data reveal that ET-1 is released during reperfusion and exsanguination and may mediate remote vascular events associated with infrarenal aortic cross clamping and acute blood loss.
AB - Endothelin-1 (ET-1) is a potent vasoconstrictive polypeptide produced from vascular endothelial cells. The effects of ischaemia, reperfusion, and exsanguination on plasma ET-1 levels were studied and compared in the mongrel dog after infrarenal aortic cross clamping. Ischaemia produced a trend toward increased ET-1 serum levels (p <0.07 with Bonferroni correction) that did not reach significance. Plasma ET-1 levels were significantly increased during reperfusion and even further elevations were found following exsanguination. We found a 2-3 fold increase in ET-1 levels following reperfusion (Initial 3.19 ± 0.27 pg/ml vs. Reperfusion maximum 6.32 ± 0.72 pg/ml, Bonferroni p <0.01). Haemorrhagic shock was associated with a 3-4 fold increase in ET-1 levels (Initial 3.19 ± 0.27 pg/ml vs. Exsanguination maximum 8.37 ± 0.97 pg/ ml Bonferroni p <0.001). These data reveal that ET-1 is released during reperfusion and exsanguination and may mediate remote vascular events associated with infrarenal aortic cross clamping and acute blood loss.
UR - http://www.scopus.com/inward/record.url?scp=0027948604&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027948604&partnerID=8YFLogxK
U2 - 10.1016/S0950-821X(05)80654-1
DO - 10.1016/S0950-821X(05)80654-1
M3 - Article
C2 - 7828751
AN - SCOPUS:0027948604
VL - 8
SP - 729
EP - 734
JO - European Journal of Vascular and Endovascular Surgery
JF - European Journal of Vascular and Endovascular Surgery
SN - 1078-5884
IS - 6
ER -