Endothelium, vasopressin receptors, and resistance to DOCA-salt hypertension

Charles Bockman, W. B. Jeffries, W. A. Pettinger, Peter W. Abel

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Mesenteric artery rings from Wistar and Wistar-Furth rats subcutaneously treated with deoxycorticosterone acetate (DOCA) and 1% NaCl drinking water were used to measure endothelial modulation of contractile sensitivity and vasopressin receptor function and affinity. DOCA-salt hypertension reduced contractile sensitivity to arginine vasopressin (AVP) and did not affect contractile sensitivity to norepinephrine in arteries from Wistar rats. Endothelial removal caused a threefold increase in contractile sensitivity to AVP and norepinephrine in DOCA-salt hypertensive Wistar rats. In Wistar- Furth rats, DOCA-salt treatment did not affect contractile sensitivity to AVP, lysine vasopressin, oxytocin, and norepinephrine or the affinity of the vasopressin receptor for agonists or antagonists. Removal of endothelium did not affect vasopressin contractile sensitivity but caused a 15-fold increase in contractile sensitivity to norepinephrine in untreated or DOCA-salt- treated Wistar-Furth rats. These data show that reduced vasopressin receptor function and increased endothelial function that compensate for increased contractile sensitivity in arteries from DOCA-salt hypertensive Wistar rats are not the cause of resistance of DOCA-salt-treated Wistar-Furth rats to the development of enhanced contractile sensitivity and hypertension.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume265
Issue number1 34-1
StatePublished - 1993

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Vasopressin Receptors
Desoxycorticosterone
Endothelium
Inbred WF Rats
Acetates
Salts
Hypertension
Arginine Vasopressin
Norepinephrine
Wistar Rats
Arteries
Lypressin
Mesenteric Arteries
Oxytocin
Vasopressins
Drinking Water

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

Endothelium, vasopressin receptors, and resistance to DOCA-salt hypertension. / Bockman, Charles; Jeffries, W. B.; Pettinger, W. A.; Abel, Peter W.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 265, No. 1 34-1, 1993.

Research output: Contribution to journalArticle

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